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Encyclopedia of Signaling Molecules pp 1–11Cite as

Laminin β2

  • Living reference work entry
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Synonyms

LAMB2; Lamb2; Laminin S chain; Laminin β2; Laminin β2 chain; Lams; S-laminin

Historical Background

Laminin β2 was identified as basement membrane a component in neuromuscular junctions (NMJs). Basement membranes are thin sheet-like structures that abut many cell types, including epithelial, endothelial, fat, muscle, and peripheral nerve cells. They influence tissue compartmentalization and cellular phenotypes during developmental and regenerative processes. Although a pure basement membrane was necessary to investigate its composition, it was difficult to purify the basement membrane from various tissues, including NMJs. The Matrigel matrix, an extract derived from mouse Engelbreth-Holm-Swarm sarcoma, is composed of type IV collagen, laminin, nidogen, and perlecan, which are the major components of basement membranes. Therefore, the Matrigel matrix has been used as a reconstituted basement membrane. Although Matrigel has significantly advanced many studies of basement...

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Authors and Affiliations

  1. Laboratory of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan

    Yamato Kikkawa

  2. Department of Anatomy and Cell Biology, University of Kansas, School of Medicine, 3901 Rainbow Blvd, 3051, Kansas City, KS, 66160, USA

    Hiroshi Nishimune

Authors
  1. Yamato Kikkawa
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  2. Hiroshi Nishimune
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Corresponding author

Correspondence to Hiroshi Nishimune .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Kikkawa, Y., Nishimune, H. (2016). Laminin β2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101519-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101519-1

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  • Online ISBN: 978-1-4614-6438-9

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