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Encyclopedia of Signaling Molecules pp 1–10Cite as

RIAM (Rap1-Interactive Adaptor Molecule)

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Synonyms

Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (APBB1IP); Proline-rich EVH1 ligand 1 (PREL1); Retinoic acid-responsive proline-rich protein 1 (RARP-1)

Historical Background

RIAM was identified in a search of new effector molecules of the small guanosine triphosphatase (GTPase) Rap1, using the yeast two-hybrid system screen. Due to its interaction with Rap1, the newly identified Rap1-interacting effector was named RIAM (Rap1-interacting adaptor molecule) (Lafuente et al. 2004). Before its identification as a Rap1-interacting molecule, RIAM was found as a binding partner of the amyloid beta (A4) precursor protein-binding, family B, member 1 (APBB1) – also known as neural Fe65 protein – and was termed amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (APBB1IP) (Ermekova et al. 1997). In an independent study, RIAM was identified as a protein whose expression was induced in response to all-transretinoic acid...

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Acknowledgments

This work was supported by NIH grants CA183605, CA183605S1, and AI098129-01 and the DoD grant PC140571 (VAB), SAF2012-34561, and SAF2016-77096- R (EML).

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Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA

    Kankana Bardhan, Nikolaos Patsoukis, Duygu Sari, Jessica D. Weaver, Lequn Li, Laura Strauss & Vassiliki A. Boussiotis

  2. School of Medicine, Unit of Immunology, Complutense University of Madrid, 28040, Madrid, Spain

    Alvaro Torres-Gomez & Esther M. Lafuente

  3. Division of Thoracic Surgery at Tongji Hospital Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China

    Lequn Li

Authors
  1. Kankana Bardhan
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  2. Nikolaos Patsoukis
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  3. Duygu Sari
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  4. Jessica D. Weaver
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  5. Lequn Li
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  6. Alvaro Torres-Gomez
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  7. Laura Strauss
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  8. Esther M. Lafuente
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  9. Vassiliki A. Boussiotis
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Corresponding author

Correspondence to Kankana Bardhan .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Bardhan, K. et al. (2016). RIAM (Rap1-Interactive Adaptor Molecule). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101516-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101516-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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