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G alpha o

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 110 Accesses

Synonyms

Gαo; Gαo1; Gαo2; GNAO1

Historical Background

Heterotrimeric G proteins, consisting of the three subunits α, β, and γ, belong to a family of guanine nucleotide-binding proteins that are involved as transducers in various transmembrane signaling systems. Gs and Gi proteins are involved in the hormonal regulation of adenylate cyclase activity. Gs activates cyclase in response to β-adrenergic stimuli, whereas the Gi protein mediates the inhibition of cyclase (Hepler and Gilman 1992). Bordetella pertussis toxin (PTX) was isolated as the islet-activating protein by Ui and his colleagues. PTX mediates the ADP ribosylation of Gi proteins (Katada and Ui 1982). The Go protein was isolated during the purification of Gi proteins from bovine brain for use as the substrate for PTX-mediated ADP ribosylation and was named the “other” G protein. The Go protein contains three subunits with molecular weights of 39 kDa (α subunit), 36 kDa (β subunit), and 8 kDa (γ subunit). The first cDNA clone...

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References

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Authors and Affiliations

  1. Laboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, 156-8506, Tokyo, Japan

    Tomohiro Iguchi & Kohji Kasahara

Authors
  1. Tomohiro Iguchi
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  2. Kohji Kasahara
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Correspondence to Kohji Kasahara .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Iguchi, T., Kasahara, K. (2016). G alpha o. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101497-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101497-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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