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Encyclopedia of Signaling Molecules pp 1–11Cite as

Adenomatous Polyposis Coli

  • Living reference work entry
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Synonyms

Adenomatosis polyposis coli; Adenomatosis polyposis coli tumor suppressor; APC; Deleted in polyposis 2.5 (DP2.5); Protein phosphatase 1, regulatory subunit 46 (PPP1R46); Truncated adenomatosis polyposis coli

Historical Context

“You are old, Father William,” the young surgeon said,

“And your colon from polyps is free.

Yet most of your siblings are known to be dead –

A really bad family tree”

“In my youth,” Father William replied with a grin,

“I was told that a gene had mutated,

That all who carried this dominant gene

To polyps and cancer were fated.”

Cuthbert Dukes, from a speech entitled “

Familial Intestinal Polyps” delivered to the Royal College of Surgeons of England March 25th, 1952

Familial adenomatous polyposis (FAP) was first thought to be identified by H. Luschka in 1861, who described a colon containing thousands of polyps. The hereditary nature of this disease came into focus with a second case report in 1882 by Cripps who identified polyposis within two members of...

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References

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Authors and Affiliations

  1. Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA

    Jonathan Alexander, Antonella Pirone & Michele Jacob

Authors
  1. Jonathan Alexander
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  2. Antonella Pirone
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  3. Michele Jacob
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Corresponding authors

Correspondence to Jonathan Alexander or Antonella Pirone .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Alexander, J., Pirone, A., Jacob, M. (2016). Adenomatous Polyposis Coli. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101487-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101487-1

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  • Online ISBN: 978-1-4614-6438-9

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