Nuclear Myosin I
Nuclear myosin I (NM1) belongs to the group of class I myosins, which are monomeric, nonprocessive, slow-rate, and low-duty ratio molecular motors transforming free chemical energy stored in ATP into mechanical force. Nuclear myosin I was discovered by testing antibodies to adrenal myosin 1. The antibody was staining a 120 kDa nuclear protein with ATPase activity, and the protein was ATP-, actin-, and calmodulin- binding, which are the typical features of unconventional myosins. At that time, there were no myosins known to be present in the cell nucleus, hence the discovered protein was called nuclear myosin I (Pestic-Dragovich et al. 2000). The mass spectrometric analysis of the NM1 showed a high homology to the Myosin 1c (Myo1c) protein, the first single-headed myosin isolated from mammals, also known as mammalian myosin I, or myosin 1β. However, with the increasing numbers of myosins discovered, there...
KeywordsMigration Alanin Acetyl Transferase
- Hedberg Oldfors C, Dios DG, Linder A, Visuttijai K, Samuelson E, Karlsson S, et al. Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. BMC Genet. 2015;16:80. doi:10.1186/s12863-015-0238-4.CrossRefPubMedPubMedCentralGoogle Scholar
- Sarshad A, Sadeghifar F, Louvet E, Mori R, Bohm S, Al-Muzzaini B, et al. Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression. PLoS Genet. 2013;9:e1003397. doi:10.1371/journal.pgen.1003397.CrossRefPubMedPubMedCentralGoogle Scholar
- Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, et al. Glycogen synthase kinase (GSK) 3beta phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells. PLoS Genet. 2014;10:e1004390. doi:10.1371/journal.pgen.1004390.CrossRefPubMedPubMedCentralGoogle Scholar
- Sielski NL, Ihnatovych I, Hagen JJ, Hofmann WA. Tissue specific expression of Myosin IC Isoforms. Bmc Cell Biol. 2014;15. doi:10.1186/1471-2121-15-8.Google Scholar
- Venit T, Dzijak R, Kalendova A, Kahle M, Rohozkova J, Schmidt V, et al. Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. PLoS One 2013;8. doi:10.1371/journal.pone.0061406.Google Scholar