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Molecular Life Sciences pp 1–9Cite as

Toll-Like Receptor 3: Structure and Function

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Synopsis

Toll-like receptors (TLRs) are a family of innate-immune recognition receptors able to recognize a variety of pathogen-associated molecular patterns (PAMPs) and induce the activation of a number of host defenses. Similar to the rest of the TLR family, TLR3 is a type I integral membrane glycoprotein with an N-terminal ligand recognition domain, a single transmembrane domain, and a C-terminal cytoplasmic signaling domain. TLR3 recognizes dsRNA, a molecular pattern associated with viral infection, and induces the activation of NF-κB and the production of type I interferons. Structurally, while all three domains of TLR3 have not been crystallized together, the N-terminal TLR3-ECD has been independently characterized by two groups; these groups showed that the TLR3-ECD displays a heavily glycosylated horseshoe-shaped solenoid structure consisting of 23 leucine-rich repeat motifs capped on the N- and C-termini by leucine-rich repeat domains (LRR-NT and LRR-CT). TLR3 ligand...

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Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, CA, USA

    James Marion

Authors
  1. James Marion
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Corresponding author

Correspondence to James Marion .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    Robert D. Wells

  2. Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    Judith S. Bond

  3. Department of Chemistry Department of Molecular and Cell Biology, University of California The california institute for Quanti, Berkeley, California, USA

    Judith Klinman

  4. Department of Biochemistry, The University of Texas Health Science C, San Antonio, Texas, USA

    Bettie Sue Siler Masters

  5. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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© 2014 Springer Science+Business Media New York

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Marion, J. (2014). Toll-Like Receptor 3: Structure and Function. In: Wells, R., Bond, J., Klinman, J., Masters, B., Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_772-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_772-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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