Synopsis
Homologous recombination (HR) is the preferred pathway to repair DNA double-strand breaks (DSBs) during the S and G2/M phases of the cell cycle and represents the major route for DSB repair in budding yeast, Saccharomyces cerevisiae. HR takes place in a chromatin context, and both ATP-dependent nucleosome disruption and histone modifications contribute to chromatin remodeling during HR. These chromatin-remodeling events occur at different points during repair by HR and influence the execution of discrete steps in the HR pathway.
Introduction
The nucleosomal organization of chromatin presents a formidable barrier to the access of regulatory factors to all DNA-mediated processes. To surmount this barrier, chromatin can be remodeled to expose key factor binding sites. Chromatin remodeling is classified into two broad categories and is mediated by...
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Osley, M.A. (2014). Chromatin Remodeling During Homologous Recombination Repair in Saccharomyces Cerevisiae . In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_77-2
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DOI: https://doi.org/10.1007/978-1-4614-6436-5_77-2
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