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Exploring Nuclear Lamin–Chromatin Interactions and Their Signalling Cascades

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Molecular Life Sciences

Synopsis

The structural integrity of the cell nucleus and its response to mechanical stress dictate gene expression programs and signalling in diseases and developmental stages. Lamins are an integral part of the nuclear envelope and are implied in DNA repair, transcription, replication, apoptosis, differentiation, and nuclear positioning besides distinctive roles in cellular adhesion. Though mutations in lamin A/C and in lamin B lead to a diverse set of diseases called laminopathies and though the etiology of these diseases is known, the intricate signalling between chromatin and lamin remains to be understood. Interesting epigenetic cascades have been implied in laminopathies like Hutchinson–Gilford progeria syndrome (HGPS) and in muscular dystrophies. This entry details the interactions between the chromatin and lamin in cellular systems, mouse models, and the histone cross talk in such systems. The mechanosignalling of lamin through chromatin and the epigenetic changes associated...

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Authors and Affiliations

  1. Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), School of Chemical & Biotechnology, SASTRA University, Thanjavur, Tamilnadu, India

    Shabir A. Ganai, Malli K. Shashwath & Mahadevan Vijayalakshmi

Authors
  1. Shabir A. Ganai
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  2. Malli K. Shashwath
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  3. Mahadevan Vijayalakshmi
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Corresponding author

Correspondence to Mahadevan Vijayalakshmi .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    Robert D. Wells

  2. Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    Judith S. Bond

  3. Department of Chemistry Department of Molecular and Cell Biology, University of California The california institute for Quanti, Berkeley, California, USA

    Judith Klinman

  4. Department of Biochemistry, The University of Texas Health Science C, San Antonio, Texas, USA

    Bettie Sue Siler Masters

  5. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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© 2014 Springer Science+Business Media New York

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Ganai, S.A., Shashwath, M.K., Vijayalakshmi, M. (2014). Exploring Nuclear Lamin–Chromatin Interactions and Their Signalling Cascades. In: Wells, R., Bond, J., Klinman, J., Masters, B., Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_580-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_580-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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