Exploring Nuclear Lamin–Chromatin Interactions and Their Signalling Cascades
The structural integrity of the cell nucleus and its response to mechanical stress dictate gene expression programs and signalling in diseases and developmental stages. Lamins are an integral part of the nuclear envelope and are implied in DNA repair, transcription, replication, apoptosis, differentiation, and nuclear positioning besides distinctive roles in cellular adhesion. Though mutations in lamin A/C and in lamin B lead to a diverse set of diseases called laminopathies and though the etiology of these diseases is known, the intricate signalling between chromatin and lamin remains to be understood. Interesting epigenetic cascades have been implied in laminopathies like Hutchinson–Gilford progeria syndrome (HGPS) and in muscular dystrophies. This entry details the interactions between the chromatin and lamin in cellular systems, mouse models, and the histone cross talk in such systems. The mechanosignalling of lamin through chromatin and the epigenetic changes associated...
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