Molecular Life Sciences

Living Edition
| Editors: Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters, Ellis Bell

Genomic Signature Analysis to Predict Plasmid Host Range

  • Haruo Suzuki
  • Celeste J. Brown
  • Eva M. Top
Living reference work entry

Later version available View entry history

DOI: https://doi.org/10.1007/978-1-4614-6436-5_574-1

Synopsis

Plasmids differ in their ability to maintain themselves in different hosts, and this determines the extent to which they can spread the genes they carry to bacteria of different species in their local environment. The rate at which new sequence information is accumulating means that it is impracticable to test the host range of all new plasmids empirically so ways of predicting host range from their sequence will provide important ways of classifying plasmids and in some cases assessing risk and directing resources. Different bacteria have different genomic sequence signatures of nucleotide composition, and it appears that plasmids that are associated permanently with bacteria of a single signature type tend to acquire that signature while plasmids that move around more between bacterial types are less adapted to any host type. This short entry describes progress in developing this simple concept as an approach to analyzing plasmid genomes and using this information to predict...

Keywords

Host Range Genomic Signature Related Bacterium Evolutionary Host Plasmid Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Population Medicine and Diagnostic Sciences, College of Veterinary MedicineCornell UniversityIthacaUSA
  2. 2.Department of Biological Sciences, Institute for Bioinformatics and Evolutionary Studies (IBEST)University of IdahoMoscowUSA