Genomic Signature Analysis to Predict Plasmid Host Range
Plasmids differ in their ability to maintain themselves in different hosts, and this determines the extent to which they can spread the genes they carry to bacteria of different species in their local environment. The rate at which new sequence information is accumulating means that it is impracticable to test the host range of all new plasmids empirically so ways of predicting host range from their sequence will provide important ways of classifying plasmids and in some cases assessing risk and directing resources. Different bacteria have different genomic sequence signatures of nucleotide composition, and it appears that plasmids that are associated permanently with bacteria of a single signature type tend to acquire that signature while plasmids that move around more between bacterial types are less adapted to any host type. This short entry describes progress in developing this simple concept as an approach to analyzing plasmid genomes and using this information to predict...
KeywordsRecombination Dinucleotide Proteobacteria Gammaproteobacteria Enterobacteriales
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