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Molecular Life Sciences pp 1–6Cite as

DNA Repair

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Synopsis

DNA damage threatens the integrity of the DNA genome that is paramount to inheritance of genetic material. There are many types of DNA damage and correspondingly, numerous DNA repair mechanisms. Historically, UV damage and its repair were the first to be discovered. Environmental exposure to UV and ionizing radiation remain important contributors to the most frequent and severe types of damage in humans, respectively, which if unrepaired can result in chromosome loss. This entry examines the mechanisms and regulation of the DNA repair process that are crucial to all organisms.

Introduction

Our current understanding of the mechanisms of the repair of damage to DNA had its origin nearly 60 years ago with the investigation of a rather esoteric subject, the radiation (UV) sensitivity of bacteria. Initially the field was dominated by bacterial geneticists whose work led to the isolation of large numbers of radiation-sensitive mutants and ultimately the identification of bacterial...

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Authors and Affiliations

  1. Department of Biochemistry, Beckman Center, Stanford University School of Medicine, 94305, Stanford, CA, USA

    I. Robert Lehman

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  1. I. Robert Lehman
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Correspondence to I. Robert Lehman .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    Robert D. Wells

  2. Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    Judith S. Bond

  3. Department of Chemistry Department of Molecular and Cell Biology, University of California The california institute for Quanti, Berkeley, California, USA

    Judith Klinman

  4. Department of Biochemistry, The University of Texas Health Science C, San Antonio, Texas, USA

    Bettie Sue Siler Masters

  5. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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© 2014 Springer Science+Business Media New York

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Lehman, I.R. (2014). DNA Repair. In: Wells, R., Bond, J., Klinman, J., Masters, B., Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_465-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_465-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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