Synopsis
Control of gene expression begins with rendering DNA more or less accessible to the transcription machinery. DNA is packaged around histones and other proteins to form chromatin. Histones condense DNA but also limit its accessibility to the transcription machinery. DNA that is packaged tightly and inaccessible to transcription machinery is referred to as heterochromatin, while loosely packaged DNA that can be transcribed is termed euchromatin.
Since transcription depends upon accessible DNA, chromatin modification provides a powerful means for the cell to regulate gene expression. Indeed, chromatin state is dynamic, changing over time or due to alterations in the cell’s environment. Chromatin state varies between cell types and is one way that cells in different tissues show unique patterns of gene expression. Importantly, chromatin state is...
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Khan, S., Hilliker, A. (2014). Role of Chromatin Remodeling and DNA Modification in Transcriptional Regulation. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_39-2
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DOI: https://doi.org/10.1007/978-1-4614-6436-5_39-2
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