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Molecular Life Sciences pp 1–9Cite as

TANK-Binding Kinase 1 (TBK1): Structure, Function, and Regulation

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Synopsis

Originally discovered as a kinase that interacted with the effector proteins TANK and TRAF2 in a ternary complex that could activate NF-κB, TANK-binding kinase 1 (TBK1) has since been characterized as a key regulator of substrates ranging from cell proliferation and vesicle transport to xenophagic elimination of bacteria and antiviral immune response. Also known as NAK (NF-κB-activating kinase) or T2K (TRAF2-associated kinase), TBK1 is a ubiquitously expressed 729-amino-acid serine/threonine kinase that is a noncanonical IκB kinase family member, targeting the transcription factors IRF3 and IRF7 in the type I interferon response. TBK1 is composed of an N-terminal kinase domain (KD), which contains an activation loop between subdomains VII and VIII controlling its catalytic activity, and three C-terminal regulatory domains: a ubiquitin-like domain (ULD), which interacts with the KD rather than the known ubiquitin-binding proteins and appears to be necessary for substrate...

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA

    James Marion

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  1. James Marion
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Correspondence to James Marion .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    Robert D. Wells

  2. Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    Judith S. Bond

  3. Department of Chemistry Department of Molecular and Cell Biology, University of California The california institute for Quanti, Berkeley, California, USA

    Judith Klinman

  4. Department of Biochemistry, The University of Texas Health Science C, San Antonio, Texas, USA

    Bettie Sue Siler Masters

  5. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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© 2014 Springer Science+Business Media New York

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Marion, J. (2014). TANK-Binding Kinase 1 (TBK1): Structure, Function, and Regulation. In: Wells, R., Bond, J., Klinman, J., Masters, B., Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_374-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_374-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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