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Pattern Recognition Receptors: Evolution, Redundancy, and Cross Talk

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Molecular Life Sciences

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Synopsis

Pattern recognition receptors (PRRs) mediate identification of two classes of molecules. The first, pathogen-associated molecular patterns (PAMPs), consists of evolutionarily conserved repeating patterns of molecular structures found on the surfaces of, or in the nucleic acid sequences of, related pathogenic microbes. The second, damage-associated molecular patterns (DAMPs), consists of endogenous molecules released from stressed, injured, infected, or transformed human cells. PRRs reside on various cells (macrophages, neutrophils, dendritic, epithelial, endothelial, keratinocytes, etc.) or are secreted to act as sentinels in the bloodstream and lymph nodes and are compromised of three functionally distinct classes: endocytic, secreted, and signaling PRRs. Endocytic PRRs, found on the surface of phagocytes, recognize a range of carbohydrates. Secreted PRRs bind to microbial cell walls and facilitate their recognition by phagocytes or the complement pathways. Signaling PRRs...

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, CA, USA

    James Marion

Authors
  1. James Marion
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Correspondence to James Marion .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    Robert D. Wells

  2. Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    Judith S. Bond

  3. Department of Chemistry Department of Molecular and Cell Biology, University of California The california institute for Quanti, Berkeley, California, USA

    Judith Klinman

  4. Department of Biochemistry, The University of Texas Health Science C, San Antonio, Texas, USA

    Bettie Sue Siler Masters

  5. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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© 2014 Springer Science+Business Media New York

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Marion, J. (2014). Pattern Recognition Receptors: Evolution, Redundancy, and Cross Talk. In: Wells, R., Bond, J., Klinman, J., Masters, B., Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_369-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_369-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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