Skip to main content
SpringerLink
Log in

Toll-Like Receptors: Pathogen Recognition and Signaling

  • Living reference work entry
  • First Online:
Book cover Molecular Life Sciences

  • 207 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Adachi O, Kawai T, Takeda K et al (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function. Immunity 9:143–150

    Article  CAS  PubMed  Google Scholar 

  • Andersen-Nissen E, Smith KD, Strobe KL et al (2005) Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A 102:9247–9252

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bell JK, Botos I, Hall PR et al (2005) The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci U S A 102:10976–10980

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Botos I, Segal DM, Davies DR (2011) The structural biology of Toll-like receptors. Structure 19:447–459. doi:10.1016/j.str.2011.02.004, S0969-2126(11)00072-4 [pii]\r

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ewald SE, Lee BL, Lau L et al (2008) The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456:658–662

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ewald SE, Engel A, Lee J et al (2011) Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med 208:643–651

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG et al (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413:78–83

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Cattaneo A, Gobert F-X, Muller M et al (2012) Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling. Proc Natl Acad Sci 109:9053–9058

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Govindaraj RG, Manavalan B, Lee G, Choi S (2010) Molecular modeling-based evaluation of hTLR10 and identification of potential ligands in toll-like receptor signaling. PLoS One 5:1–13

    Article  Google Scholar 

  • Jin MS, Kim SE, Heo JY et al (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071–1082

    Article  CAS  PubMed  Google Scholar 

  • Kang JY, Nan X, Jin MS et al (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31:873–884

    Article  CAS  PubMed  Google Scholar 

  • Kim HM, Park BS, Kim JI et al (2007) Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran. Cell 130:906–917

    Article  CAS  PubMed  Google Scholar 

  • Kim Y-M, Brinkmann MM, Paquet M-E, Ploegh HL (2008) UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452:234–238

    Article  CAS  PubMed  Google Scholar 

  • Kumar H, Kawai T, Akira S (2009) Pathogen recognition in the innate immune response. Biochem J 420:1–16

    Article  CAS  PubMed  Google Scholar 

  • Lemmon MA (1994) Specificity and promiscuity in membrane helix interactions. FEBS Lett 346:17–20

    Article  CAS  PubMed  Google Scholar 

  • Li C, Zienkiewicz J, Hawiger J (2005) Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1B signaling pathway. J Biol Chem 280:26152–26159

    Article  CAS  PubMed  Google Scholar 

  • Motshwene PG, Moncrieffe MC, Grossmann JG et al (2009) An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem 284:25404–25411

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • O’Neill LAJ, Bowie AG (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7:353–364

    Article  PubMed  Google Scholar 

  • Poltorak A, He X, Smirnova I et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085–2088

    Article  CAS  PubMed  Google Scholar 

  • Qi R, Singh D, Kao CC (2012) Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization. J Biol Chem 287:32617–32629

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Schneider DS, Hudson KL, Lin TY, Anderson KV (1991) Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev 5:797–807

    Article  CAS  PubMed  Google Scholar 

  • Sepulveda FE, Maschalidi S, Colisson R et al (2009) Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity 31:737–748

    Article  CAS  PubMed  Google Scholar 

  • Tabeta K, Hoebe K, Janssen EM et al (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7:156–164

    Article  CAS  PubMed  Google Scholar 

  • Tanji H, Ohto U, Shibata T et al (2013) Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science 339:1426–1429

    Article  CAS  PubMed  Google Scholar 

  • Weber ANR, Tauszig-Delamasure S, Hoffmann JA et al (2003) Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling. Nat Immunol 4:794–800

    Article  CAS  PubMed  Google Scholar 

  • Wei T, Gong J, Jamitzky F et al (2009) Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains. Protein Sci 18:1684–1691

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Yoon S-i, Kurnasov O, Natarajan V et al (2012) Structural basis of TLR5-flagellin recognition and signaling. Science 335:859–864

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA

    James Marion

Authors
  1. James Marion
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James Marion .

Editor information

Editors and Affiliations

  1. Department of Chemistry, Texas A&M University, College Station, Texas, USA

    Robert D. Wells

  2. Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania, USA

    Judith S. Bond

  3. Department of Chemistry Department of Molecular and Cell Biology, University of California The california institute for Quanti, Berkeley, California, USA

    Judith Klinman

  4. Department of Biochemistry, The University of Texas Health Science C, San Antonio, Texas, USA

    Bettie Sue Siler Masters

  5. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Marion, J. (2014). Toll-Like Receptors: Pathogen Recognition and Signaling. In: Wells, R., Bond, J., Klinman, J., Masters, B., Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_360-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_360-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation