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Exocyclic Adducts

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Molecular Life Sciences

Synopsis

Exocyclic DNA adducts are those in which an extra ring or rings have been added to the DNA base, either a purine or pyrimidine. These are often problematic in that they disrupt the normal DNA coding with the opposite strand. Some of the most common exocyclic adducts are the so-called etheno (ε) adducts, which (as the name would imply) contain an extra two carbons. These etheno adducts were first studied because of their relevance to the carcinogenicity of vinyl chloride, but subsequently they were found to also be derived form peroxidation of unsaturated fatty acids and are present in humans who have never been exposed to vinyl chloride or other vinyl monomers. Most of these exocyclic DNA adducts have been found to be miscoding, and there is considerable interest regarding them in the etiology of human cancer.

Introduction

The exocyclic adducts are an eclectic group of DNA adducts having only the commonality of containing extra rings. These adducts arise from the reaction of...

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Authors and Affiliations

  1. Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA

    F. Peter Guengerich

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  1. F. Peter Guengerich
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Correspondence to F. Peter Guengerich .

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Editors and Affiliations

  1. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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Guengerich, F.P. (2014). Exocyclic Adducts. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_206-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_206-1

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  • Online ISBN: 978-1-4614-6436-5

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