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The Mammalian Solute Carrier Families SLC2 and SLC5: Facilitative and Active Transport of Hexoses and Polyols

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Molecular Life Sciences

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Synonyms

Glucose homeostasis; Glucose transport facilitator; Glucose transporter; GLUT; Inherited disorders; Knockout mice; SGLT; Sodium-dependent glucose transport; Symporter; Type 2 diabetes; Uric acid

Synopsis

This entry summarizes the principal characteristics of sodium-dependent, active (SGLT; Wright et al. 2011) and facilitative (GLUT; Augustin 2010) sugar transport in mammalian cells, primarily focusing on the human transporters. Emphasis is placed on the physiology of such transporters, based on inherited disorders and syndromes in humans and the phenotypic characteristics of genetically modified mice.

Introduction

Glucose represents the major energy source of mammalian cells. Due to its hydrophilic nature, glucose requires specific transporters in order to cross cellular membranes. Such transport is, in the case of glucose and also other monosaccharides, mediated by energy-coupled as well as facilitative mechanisms represented by protein families of sodium-driven sugar...

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Author information

Authors and Affiliations

  1. Department of Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharma GmbH & Co KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany

    Robert Augustin & Eric Mayoux

Authors
  1. Robert Augustin
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  2. Eric Mayoux
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Corresponding author

Correspondence to Robert Augustin .

Editor information

Editors and Affiliations

  1. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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Augustin, R., Mayoux, E. (2014). The Mammalian Solute Carrier Families SLC2 and SLC5: Facilitative and Active Transport of Hexoses and Polyols. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_188-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_188-2

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6436-5

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