Synopsis
DNA replication is an essential process required for the propagation of all pathogens. This provides a useful target for the development of antimicrobial chemotherapeutic agents. The target is increased in value because of observations that blocking replication after it has initiated often leads to chromosomal degradation and bactericidal outcomes. Recent advances in using purified replication systems to screen for antibacterial agents and the use of naturally occurring anti-replication proteins encoded by phages to identify new targets are reviewed.
Introduction
DNA replication is an essential process for the proliferation of all pathogens and offers a largely unexplored target for development of novel antibacterials. Therapeutically useful inhibitors have been developed that inhibit processes upstream (nucleotide precursor biosynthesis) (Hawser et al. 2006) and downstream (DNA gyrase) (Mitscher 2005) of DNA replication. Most of the subunits of the bacterial DNA replication...
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McHenry, C. (2014). Chemical Biology of DNA Replication. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_133-1
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DOI: https://doi.org/10.1007/978-1-4614-6436-5_133-1
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