Definition
As a field, clinical research is increasingly moving toward the goal of precision medicine (Insel 2014), an initiative that highlights the importance of taking into consideration individual differences from the genetic to behavioral level when formulating effective treatment plans. Recent advancements have increasingly adopted an interdisciplinary approach to overcome two major barriers: (1) to better characterize how a treatment can elicit change at the individual level, and (2) to predict whowill most likely respond to the intervention. Successful integration of neuroimaging techniques and behavioral measures have the potential to guide identification of sensitive and objective biomarkers that can reflect and predict response to specific evidence-based treatment models in individuals with autism spectrum disorder (ASD). By integrating knowledge from social and cognitive neuroscience that have shown atypical neural response among individuals with ASD when processing...
References and Reading
Adolphs, R. (2009). The social brain: Neural basis of social knowledge. Annual Review of Psychology, 60, 693–716. doi:10.1146/annurev.psych.60.110707.163514.
Baron-Cohen, S. (1997). Mindblindness: An essay on autism and theory of mind. Cambridge: MIT Press.
Brothers, L. (2001). Friday’s footprint: How society shapes the human mind. Oxford, New York: Oxford University Press.
Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., & Schultz, R. T. (2012). The social motivation theory of autism. Trends in Cognitive Sciences, 16(4), 231–239. doi:10.1016/j.tics.2012.02.007.
Frith, C. D., & Frith, U. (1999). Interacting minds – A biological basis. Science, 286(5445), 1692–1695.
Insel, T. R. (2014). The NIMH research domain criteria (RDoC) project: Precision medicine for psychiatry. American Journal of Psychiatry, 171(4), 395–397. doi:10.1176/appi.ajp.2014.14020138.
Johansson, G. (1973). Visual perception of biological motion and a model for its analysis. Perception & Psychophysics, 14(2), 201–211. doi:10.3758/BF03212378.
Kaiser, M. D., Hudac, C. M., Shultz, S., Lee, S. M., Cheung, C., Berken, A. M., et al. (2010). Neural signatures of autism. Proceedings of the National Academy of Sciences of the United States of America, 107(49), 21223–21228. doi:10.1073/pnas.1010412107.
Klin, A., Lin, D. J., Gorrindo, P., Ramsay, G., & Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature, 459(7244), 257–261. doi:10.1038/nature07868.
Koegel, L. K., Camarata, S. M., Valdez-Menchaca, M., & Koegel, R. L. (1998). Setting generalization of question-asking by children with autism. American Journal of Mental Retardation, 102(4), 346–357.
Koegel, R. L., Dyer, K., & Bell, L. K. (1987). The influence of child-preferred activities on autistic children’s social behavior. Journal of Applied Behavior Analysis, 20(3), 243–252. doi:10.1901/jaba.1987.20-243.
Koegel, R. L., & Egel, A. L. (1979). Motivating autistic children. Journal of Abnormal Psychology, 88(4), 418–426.
Koegel, R. L., & Koegel, L. K. (2012). Treatment of pivotal areas. In R. L. Koegel & R. L. Koegel (Eds.), The PRT pocket guide: Pivotal response treatment for autism spectrum disorders (pp. 13–38). Baltimore: Paul H. Brookes Publishing.
Markram, K., & Markram, H. (2010). The intense world theory – A unifying theory of the neurobiology of autism. Frontiers in Human Neuroscience, 4. doi:10.3389/fnhum.2010.00224.
Oram, M. W., & Perrett, D. I. (1994). Responses of anterior superior temporal polysensory (STPa) neurons to “biological motion” stimuli. Journal of Cognitive Neuroscience, 6(2), 99–116. doi:10.1162/jocn.1994.6.2.99.
Oram, M. W., & Perrett, D. I. (1996). Integration of form and motion in the anterior superior temporal polysensory area (STPa) of the macaque monkey. Journal of Neurophysiology, 76(1), 109–129.
Pavlova, M. A. (2012). Biological motion processing as a hallmark of social cognition. Cerebral Cortex, 22(5), 981–995. doi:10.1093/cercor/bhr156.
Pelphrey, K. A., Mitchell, T. V., McKeown, M. J., Goldstein, J., Allison, T., & McCarthy, G. (2003). Brain activity evoked by the perception of human walking: Controlling for meaningful coherent motion. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23(17), 6819–6825.
Puce, A., & Perrett, D. (2003). Electrophysiology and brain imaging of biological motion. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 358(1431), 435–445. doi:10.1098/rstb.2002.1221.
Vaina, L. M., Solomon, J., Chowdhury, S., Sinha, P., & Belliveau, J. W. (2001). Functional neuroanatomy of biological motion perception in humans. Proceedings of the National Academy of Sciences, 98(20), 11656–11661. doi:10.1073/pnas.191374198.
Venkataraman, A., Yang, D. Y.-J., Dvornek, N., Staib, L. H., Duncan, J. S., Pelphrey, K. A., & Ventola, P. (2016). Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder. Neuroreport, 27(14), 1081–1085. doi:10.1097/WNR.0000000000000662.
Ventola, P., Yang, D. Y., Friedman, H. E., et al. (2015). Heterogeneity of neural mechanisms of response to pivotal response treatment. Brain Imaging and Behavior, 9(1), 74–88.
Verschuur, R., Didden, R., Lang, R., Sigafoos, J., & Huskens, B. (2013). Pivotal response treatment for children with autism Spectrum disorders: A systematic review. Review Journal of Autism and Developmental Disorders, 1(1), 34–61. doi:10.1007/s40489-013-0008-z.
Voos, A. C., Pelphrey, K. A., Tirrell, J., Bolling, D. Z., Wyk, B. V., Kaiser, M. D., et al. (2012). Neural mechanisms of improvements in social motivation after pivotal response treatment: Two case studies. Journal of Autism and Developmental Disorders, 43(1), 1–10. doi:10.1007/s10803-012-1683-9.
Yang, D., Pelphrey, K. A., Sukhodolsky, D. G., Crowley, M. J., Dayan, E., Dvornek, N. C., et al. (2016). Brain responses to biological motion predict treatment outcome in young children with autism. Translational Psychiatry, 6(11), e948. doi:10.1038/tp.2016.213.
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Lei, J., Ventola, P.E. (2017). Neural Signatures of Treatment Response. In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_102192-1
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DOI: https://doi.org/10.1007/978-1-4614-6435-8_102192-1
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