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Despite advancements in cognitive-behavior therapies, no single pharmacological therapy has successfully treated the disruptive-compulsive behaviors of Autism Spectrum Disorders (ASD), which include hand-flapping, tantrums, and self-injurious behaviors (Fido and Al-Saad 2008). Among the pharmacological agents examined to reduce disruptive-compulsive behaviors, atypical antipsychotics, including olanzapine, showed the most promise (Fido and Al-Saad 2008; Malek-Ahmadi and Simonds 1998; Malone et al. 2001). Specifically, ASD children prescribed olanzapine showed significant reductions in irritability, hyperactivity, and lethargy (Fido and Al-Saad 2008; Malek-Ahmadi and Simonds 1998; Malone et al. 2001). Unlike typical antipsychotic medications, atypical antipsychotic medications block postsynaptic dopamine and serotonin receptors and have a lower risk of extrapyramidal symptoms, such as dyskinesias, among children and adolescents (Malone et al. 2001)....
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References and Reading
Chiang, C.-l., Lin, Y.-H., & Hsieh, M. H. (2013). Olanzapine-induced hyponatremia in a patient with autism. Journal of Child and Adolescent Psychopharmacology, 23(10), 699–700. https://doi.org/10.1089/cap.2013.0055.
Fido, A., & Al-Saad, S. (2008). Olanzapine in the treatment of behavioral problems associated with autism: An open-label trial in Kuwait. Medical Principles and Practice, 17(5), 415–418. https://doi.org/10.1159/000141508.
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Malek-Ahmadi, P., & Simonds, J. F. (1998). Olanzapine for autistic disorder with hyperactivity. Journal of the American Academy of Child & Adolescent Psychiatry, 37(9), 902–903. https://doi.org/10.1097/00004583-199809000-00006.
Malone, R. P., Cater, J., Sheikh, R. M., Choudhury, M. S., & Delaney, M. A. (2001). Olanzapine versus haloperidol in children with autistic disorder: An open pilot study. Journal of the American Academy of Child & Adolescent Psychiatry, 40(8), 887–894. https://doi.org/10.1097/00004583-200108000-00009.
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Kopel, J. (2019). Zyprexa. In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_102100-1
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DOI: https://doi.org/10.1007/978-1-4614-6435-8_102100-1
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