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Sedation of intellectually disabled patients, such as autism spectrum disorders (ASD), is often applied before invasive or lengthy surgical procedures (Lim et al. 2018). It is estimated that 30% of patients with intellectual disabilities are uncooperative before receiving general anesthesia (Lim et al. 2018). In order to avoid hard restraints, three general sedatives, midazolam, ketamine, and dexmedetomidine, are utilized to calm ASD patients before receiving general anesthesia (Lim et al. 2018). Recently, physicians began administering triazolam after government restrictions on midazolam use in certain countries. To determine whether triazolam was equally efficacious as midazolam, a study consisting of 97 patients with intellectual disabilities were divided into two groups receiving either midazolam or triazolam. Analysis of cooperation after drug administration showed anesthesia induction without physical restraint was possible in 56.0% of patients in the...
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Lim, S. W., So, E., Yun, H. J., Karm, M.-H., Chang, J., Lee, H., … Seo, K.-S. (2018). Analysis of the effect of oral midazolam and triazolam premedication before general anesthesia in patients with disabilities with difficulty in cooperation. Journal of Dental Anesthesia and Pain Medicine, 18(4), 245. https://doi.org/10.17245/jdapm.2018.18.4.245.
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Kopel, J. (2020). Triazolam and Autism. In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_102096-1
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DOI: https://doi.org/10.1007/978-1-4614-6435-8_102096-1
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