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Encyclopedia of Autism Spectrum Disorders pp 1–3Cite as

Prozac™ (Fluoxetine)

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Synonyms

Fludac; Fluoxin; Flutine; Fluxil; Fontex; Lovan; Philozac; Sarafem; Zactin

Definition

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD), among other disorders (Wenthur et al. 2013). Some research suggests that fluoxetine can be used to treat repetitive behaviors in individuals with autism spectrum disorder (ASD); however, findings are inconsistent and placebo-controlled studies are scarce (Accordino et al. 2016).

Fluoxetine (molecular formula: C17H18F3NO) is an oral formulation commonly known by the brand name Prozac. It was discovered by Eli Lilly and Company in 1972 and was the first SSRI to be approved for medical use by the United States Food and Drug Administration (FDA) in 1987. The introduction of fluoxetine represented a medical breakthrough in the treatment of depression and offered...

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References and Reading

  • Accordino, R. E., Kidd, C., Politte, L. C., Henry, C. A., & McDougle, C. J. (2016). Psychopharmacological interventions in autism spectrum disorder. Expert Opinion on Pharmacotherapy, 17(7), 937–952. https://doi.org/10.1517/14656566.2016.1154536.

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  • Hollander, E., Phillips, A., Chaplin, W., Zagursky, K., Novotny, S., Wasserman, S., & Iyengar, R. (2005). A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism. Neuropsychopharmacology, 30(3), 582.

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  • Hollander, E., Soorya, L., Chaplin, W., Anagnostou, E., Taylor, B. P., Ferretti, C. J., … & Settipani, C. (2012). A double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders. American Journal of Psychiatry, 169(3), 292–299.

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  • Wenthur, C. J., Bennett, M. R., & Lindsley, C. W. (2013). Classics in chemical neuroscience: fluoxetine (Prozac). ACS Chemical Neuroscience, 5(1), 14–23.

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Authors and Affiliations

  1. Yale Child Study Center, New Haven, CT, USA

    Rinatte Gruen

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  1. Rinatte Gruen
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Correspondence to Rinatte Gruen .

Editor information

Editors and Affiliations

  1. Yale Child Study Center, New Haven, CT, USA

    Fred R. Volkmar

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Gruen, R. (2018). Prozac™ (Fluoxetine). In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_102092-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6435-8_102092-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6435-8

  • Online ISBN: 978-1-4614-6435-8

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