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Lamitctal (lamotrigine)

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Encyclopedia of Autism Spectrum Disorders

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Synonyms

Lamotrigine

Mechanisms of Action

Lamotrigine is an anticonvulsant. It works by inhibiting voltage-activated sodium channels, antagonizes N-type calcium channels, and also has antiglutamatergic action. The antiglutaminergic effect is thought to be through inhibition of sodium, calcium, and potassium channels leading to decreased release of the excitatory amino acid glutamate. While there are studies to show potential favorable effects on cognition and mood stabilization, there is currently insufficient evidence to support the use of lamotrigine in Autism Spectrum Disorder

Specific Compounds and Properties

Lamotrigine is an antiepileptic drug of the phenyltriazine class.

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References and Reading

Book

  • Schatzberg, A. F., & Nemeroff, C. B. (Eds.). (2017). The American Psychiatric Association Publishing textbook of psychopharmacology. American Psychiatric Publishing.

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  • McVoy, M., & Findling, R. L. (Eds.). (2017). Clinical manual of child and adolescent psychopharmacology. American Psychiatric Publishing.

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Articles in Journal

  • Belsito, K. M., Law, P. A., Kirk, K. S., Landa, R. J., & Zimmerman, A. W. (2001). Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebo-controlled trial. Journal of Autism and Developmental Disorders, 31(2), 175–181.

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  • Kumar, B., Prakash, A., Sewal, R. K., Medhi, B., & Modi, M. (2012). Drug therapy in autism: a present and future perspective. Pharmacological Reports, 64(6), 1291–1304.

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  • Bromley, R. L., Mawer, G. E., Briggs, M., Cheyne, C., Clayton-Smith, J., García-Fiñana, M., … & Liverpool and Manchester Neurodevelopment Group. (2013). The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. Journal of Neurology, Neurosurgery, and Psychiatry. https://doi.org/10.1136/jnnp-2012-304270.

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Author information

Authors and Affiliations

  1. Child Study Centre, Yale School of Medicine, New Haven, CT, USA

    Tanuja Gandhi

Authors
  1. Tanuja Gandhi
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Corresponding author

Correspondence to Tanuja Gandhi .

Editor information

Editors and Affiliations

  1. Yale Child Study Center, New Haven, CT, USA

    Fred R. Volkmar

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Gandhi, T. (2018). Lamitctal (lamotrigine). In: Volkmar, F. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6435-8_102081-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6435-8_102081-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6435-8

  • Online ISBN: 978-1-4614-6435-8

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