Encyclopedia of Autism Spectrum Disorders

Living Edition
| Editors: Fred R. Volkmar

Antihistamines: Definition

  • Karthikeyan ArdhanareeswaranEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6435-8_102057-1

Synonyms

Definition

Antihistamines are a class of drugs that inhibit histamine, a neurotransmitter involved in mood and behavior regulation, by either (a) blocking the action of histamine at the receptor, (b) competing with histamine for binding to the receptor, or (c) displacing histamine from the receptor. In the field of ASD, the majority of interest surrounds mirtazapine and cyproheptadine, both nonselective H1 receptor (histamine receptor) inverse agonists (similar to antagonist). Mirtazapine specifically shows promise in treating inappropriate sexual behaviors associated with autism. However, the mechanism of action of both these drugs in the context of ASD is likely to be through antihistamines’ off-target highly potent antagonism of α-adrenergic receptors (fight-or-flight response) and/or serotonin (mood regulation) receptors as opposed to the H1receptor. Antihistamines may be useful in the treatment of sleeping problems...

Keywords

Receptor Antagonist Immune Cell Sexual Behavior Social Work School Psychology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References and Readings

  1. Akhondzadeh, S., Erfani, S., Mohammadi, M. R., Tehrani-Doost, M., Amini, H., Gudarzi, S. S., & Yasamy, M. T. (2004). Cyproheptadine in the treatment of autistic disorder: A double-blind placebo-controlled trial. Journal of Clinical Pharmacy and Therapeutics, 29(2), 145–150.PubMedCrossRefGoogle Scholar
  2. De Boer, T. (1996). The pharmacologic profile of mirtazapine. Journal of Clinical Psychiatry, 57, 19.PubMedGoogle Scholar
  3. Kanof, P. D., & Greengard, P. (1978). Brain histamine receptors as targets for antidepressant drugs. Nature, 272(5651), 329–333.PubMedCrossRefGoogle Scholar
  4. Posey, D. J., Guenin, K. D., Kohn, A. E., Swiezy, N. B., & McDougle, C. J. (2001). A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 11(3), 267–277.PubMedCrossRefGoogle Scholar
  5. Prell, G. D., & Green, J. P. (1986). Histamine as a neuroregulator. Annual Review of Neuroscience, 9(1), 209–254.PubMedCrossRefGoogle Scholar
  6. Stone, C. A., Wenger, H. C., Ludden, C. T., Stavorski, J. M., & Ross, C. A. (1961). Antiserotonin-antihistaminic properties of cyproheptadine. Journal of Pharmacology and Experimental Therapeutics, 131(1), 73–84.Google Scholar
  7. Thurmond, R. L., Gelfand, E. W., & Dunford, P. J. (2008). The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistamines. Nature Reviews Drug Discovery, 7(1), 41–53.PubMedCrossRefGoogle Scholar
  8. Woosley, R. L. (1996). Cardiac actions of antihistamines. Annual Review of Pharmacology and Toxicology, 36(1), 233–252.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Autism Program, Child Study CenterYale School of MedicineNew HavenUSA
  2. 2.Program in Neurodevelopment and RegenerationYale School of MedicineNew HavenUSA
  3. 3.Department of Molecular, Cellular, and Developmental BiologyYale UniversityNew HavenUSA