Obsessive Compulsive Disorders

  • Jon E. Grant
  • Samuel R. Chamberlain
Living reference work entry


Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric condition. Relatively little, however, is understood about the etiology and brain basis of OCD despite decades of research. Although neuroimaging findings in OCD frequently report abnormalities of the orbitofrontal cortex, anterior cingulate cortex, and caudate nucleus, new insights into the disorder are urgently needed. In this chapter, we review the current state of this evidence, including neuroimaging studies, genetics, neurochemical investigations, and insights from animal models.


Dopamine Glutamate Hypothalamic-pituitary-adrenal (HPA) axis Obsessive-compulsive disorder (OCD) Animal models Genome wide association studies History HPA axis Immune system Neuroanatomical circuits Neurocognition Neurotransmitter systems Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS) Serotonin 

Further Reading

  1. Burguière E, Monteiro P, Mallet L, Feng G, Graybiel AM (2015) Striatal circuits, habits, and implications for obsessive-compulsive disorder. Curr Opin Neurobiol 30:59–65CrossRefPubMedGoogle Scholar
  2. Camilla d’Angelo LS, Eagle DM, Grant JE, Fineberg NA, Robbins TW, Chamberlain SR (2014) Animal models of obsessive-compulsive spectrum disorders. CNS Spectr 19(1):28–49CrossRefPubMedGoogle Scholar
  3. Chamberlain SR, Menzies L (2009) Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential. Expert Rev Neurother 9(8):1133–1146CrossRefPubMedGoogle Scholar
  4. Grant JE (2014) Clinical practice: obsessive-compulsive disorder. N Engl J Med 371(7):646–653CrossRefPubMedGoogle Scholar
  5. Grant JE, Chamberlain SR, Odlaug BL (2014) Clinical guide to obsessive compulsive and related disorders. Oxford University Press, Oxford. ISBN 9780199977758CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Psychiatry and Behavioral NeuroscienceUniversity of Chicago, Pritzker School of MedicineChicagoUSA
  2. 2.Department of PsychiatryUniversity of Cambridge/Cambridge and Peterborough NHS Foundation Trust (CPFT)CambridgeUK

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