Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric condition. Relatively little, however, is understood about the etiology and brain basis of OCD despite decades of research. Although neuroimaging findings in OCD frequently report abnormalities of the orbitofrontal cortex, anterior cingulate cortex, and caudate nucleus, new insights into the disorder are urgently needed. In this chapter, we review the current state of this evidence, including neuroimaging studies, genetics, neurochemical investigations, and insights from animal models.
Dopamine Glutamate Hypothalamic-pituitary-adrenal (HPA) axis Obsessive-compulsive disorder (OCD) Animal models Genome wide association studies History HPA axis Immune system Neuroanatomical circuits Neurocognition Neurotransmitter systems Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS) Serotonin
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