Isolated Growth Hormone Deficiency in Children
Among children with significant short stature (height of ≤ −2.5 standard deviations (SD)), 16–20 % have growth hormone deficiency (GHD), which may be isolated (IGHD) or combined (CGHD) with deficiency of other pituitary hormones (Desai et al. 1991). Congenital IGHD occurs in 1 in 4,000 to 1 in 10,000 live births, with prevalence of 1 in 3,500 in school-age population (Lindsay et al. 1994). It is often sporadic and nonfamilial (NFIGHD) but may be familial (FIGHD) in 3–30 % (Mullis 2007; Rimoin and Phillips 1997).
KeywordsGrowth Hormone Standard Deviation Short Stature Growth Hormone Deficiency Isolate Growth Hormone Deficiency
- GH Research Society. (2000). Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. The Journal of Clinical Endocrinology and Metabolism, 85, 3990–3993.Google Scholar
- Rimoin, D. L., & Phillips, J. A., III. (1997). Genetic disorders of the pituitary gland. In D. L. Rimoin, J. M. Connor, & R. E. Pyeritz (Eds.), Principles and practice of medical genetics (3rd ed., pp. 1331–1364). New York: Churchill Livingstone.Google Scholar
- Rogol, A. D. (2014). Treatment of growth hormone deficiency in children. UpToDate. Available at www.uptodate.com/contents/