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Atlas of Genetic Diagnosis and Counseling pp 1–9Cite as

Isolated Growth Hormone Deficiency in Children

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Abstract

Among children with significant short stature (height of ≤ −2.5 standard deviations (SD)), 16–20 % have growth hormone deficiency (GHD), which may be isolated (IGHD) or combined (CGHD) with deficiency of other pituitary hormones (Desai et al. 1991). Congenital IGHD occurs in 1 in 4,000 to 1 in 10,000 live births, with prevalence of 1 in 3,500 in school-age population (Lindsay et al. 1994). It is often sporadic and nonfamilial (NFIGHD) but may be familial (FIGHD) in 3–30 % (Mullis 2007; Rimoin and Phillips 1997).

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Authors and Affiliations

  1. Perinatal and Clinical Genetics, Department of Pediatrics, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71130, USA

    Harold Chen

  2. Medical Genetics, Shriners Hospitals for Children, Shreveport, LA, USA

    Harold Chen

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  1. Harold Chen
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Correspondence to Harold Chen .

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Chen, H. (2015). Isolated Growth Hormone Deficiency in Children. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6430-3_274-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6430-3_274-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6430-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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