Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

ELDERMET (Ireland)

  • Siobhán Cusack
  • Eibhlís M. O’Connor
  • Paul W. O’Toole
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_94-1

Definition

The intestinal microbiota interacts with the diet and has important roles in maintaining human health, including modulation of the immune system. The ELDERMET project has examined whether fecal microbiota profiles from older Irish adults correlate with health, dietary, and/or lifestyle factors. This information will provide the Irish Food Industry and Medical Community with essential knowledge of the bacterial composition of older adults across a range of health states. It will provide the evidence base upon which strategies for the positive modulation of the microbiota in support of health aging may be realized.

Introduction

The Food Institutional Research Measure (FIRM), administered by the Irish Department of Agriculture, Food and the Marine, is the primary national Irish funding source for food-based research. FIRM is a competitive program that supports multidisciplinary and multi-institutional research, a significant proportion of which is focused on consumer benefits....

Keywords

Functional Food Ribosomal Database Project Microbiota Composition Fecal Microbiota Human Microbiome Project 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Claesson MJ, O’Sullivan O, Wang Q, Nikkilä J, Marchesi JR, Smidt H, et al. Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS ONE. 2009;4(8):e6669.PubMedCentralPubMedCrossRefGoogle Scholar
  2. Claesson, et al. Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions: the ELDERMET project. Nucleic Acids Res. 2010a;38(22):e200. doi:10.1093/nar/gkq873.PubMedCentralPubMedCrossRefGoogle Scholar
  3. Claesson, et al. Evaluating the latest high-throughput molecular techniques for the exploration of microbial gut communities. Gut Microbes. 2010b;1(4):277–8.PubMedCentralPubMedCrossRefGoogle Scholar
  4. Claesson, et al. Composition, variability and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4586–91. doi:10.1073/pnas.1000097107. Published online before print June 22, 2010.PubMedCentralPubMedCrossRefGoogle Scholar
  5. Clemente JC, Ursell LK, Wegener Parfrey L, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148:1258–70.PubMedCrossRefGoogle Scholar
  6. Cusack S, O’Toole PW. The human intestinal microbiota, diet and health. From infancy to old age. Agro Food Ind Hi-Tech. 2010;21(5):32–35.Google Scholar
  7. Cusack S, Claesson MJ, O’Toole PW. How beneficial is the use of probiotic supplements for the aging gut? Aging Health. 2011;7(2):179–86.CrossRefGoogle Scholar
  8. Dobriansky PJ, Suzman RM. Why population aging matters: a global perspective. National Institute on Aging, National Institutes of Health, Publication number 07–6134. www.nia.nih.gov/NR/rdonlyres/9E91407ECFE8-4903-9875D5AA75BD1D50/0/WPAM.pdf (2007).
  9. Food Harvest 2020 – A vision for the Irish agri-food and fisheries sector. Department of Agriculture, Fisheries & Food, http://www.agriculture.gov.ie/media/migration/agrifoodindustry/foodharvest2020/2020FoodHarvestEng240810.pdf(2010).
  10. Mullard A. Microbiology: the inside story. Nature. 2008;453(7195):578–80. doi:10.1038/453578a.PubMedCrossRefGoogle Scholar
  11. O’Connor EM, Fitzgerald GF, O’Toole PW. Gender differences in folate status are associated with cognition in healthy Irish elderly adults. Proc Nutr Soc. 2011;70(OCE3):E64.CrossRefGoogle Scholar
  12. O’Sullivan Ó, Coakley M, Lakshminarayanan B, Claesson MJ, Stanton C, O’Toole PW, Ross RP. Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects. J Appl Microbiol. 2011;111(2):467–73.PubMedCrossRefGoogle Scholar
  13. Power SE, O’Toole PW, O’Connor EM, Fitzgerald GF. Compliance with Irish food based dietary guidelines in community dwelling elderly subjects (The ELDERMET project). 40th Annual UCC Food Research Conference, Cork: 2011 (Conference Proceedings).Google Scholar
  14. Power SE, O’Toole PW, O’Connor EM, Fitzgerald GF. Compliance with Irish food based dietary guidelines in elderly subjects recruited from rehabilitation wards and out-patient clinics in Southern region hospitals (The ELDERMET project) 11th Annual Nursing and Midwifery Research Conference, University College Cork; 2011.Google Scholar
  15. Power SE, O’Toole PW, O’Connor EM, Fitzgerald GF. Consumption of fruit and vegetables among elderly Irish people in long term institutionalised care: the ELDERMET project. Proc Nutr Soc. 2011c;70(OCE3):E116.CrossRefGoogle Scholar
  16. Rea MC, O’Sullivan O, Shanahan F, O’Toole PW, Stanton C, Ross RP, Hill C. Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol. 2012;50:867–75.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Siobhán Cusack
    • 1
  • Eibhlís M. O’Connor
    • 1
  • Paul W. O’Toole
    • 1
  1. 1.School of Microbiology & Alimentary Pharmabiotic CentreUniversity College CorkCorcaighIreland