Early Gut Microbiome and Polymicrobial Infection
Microbiome: vast numbers of microorganisms in a given environment; in this entry, the gut of neonates.
Polymicrobial disease: several microorganisms implicated in the pathogenesis of disease.
The recent rise of “omic” technologies has led to an expansive lexicon of terms, suffixed by -ome. One such term, which is receiving more attention than most, is “microbiome.” The microbiome refers to the ecological community of commensal, symbiotic, and pathogenic microorganisms colonizing the human body. Although some controversy surrounds the original appearance of the term, Joshua Lederberg is generally accredited with the initial coinage (Lederberg and McCray 2001). This entry will focus on the importance of the microbiome in health and disease, specifically related to the temporal development of the bacterial community in the gut following birth.
Methods to Elucidate the Gut...
KeywordsBacterial Community Preterm Infant Short Bowel Syndrome Atopic Disease Necrotizing Enterocolitis
- Lederberg JD, McCray AT. ‘Ome sweet’ omics – a genealogical treasury of words. Scientist. 2001;15(7):8.Google Scholar