Colorectal Cancer-Associated Microbiota
Colonic dysbiosis: a local or disseminated change in the composition of the colonic microbiota that often leads to impaired health. Dysbiosis may either be the cause or consequence of intestinal disease.
Commensalism: a form of symbiosis where one organism benefits (the commensal) without affecting the other (the host). For example, some types of microorganisms in the lumen of the gastrointestinal tract are commensals.
COX-2 pathway: the regulatory pathway responsible for formation of important biological regulator molecules, including prostaglandins. The COX-2 enzyme is not detectable in most healthy tissues but is upregulated during inflammation and in carcinomas. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, inhibit the COX-2 pathway and decrease the risk for CRC.
Genotoxin: a compound capable of causing damage to, or genetic mutations in, DNA (synonyms: mutagenic or...
KeywordsAdenoma Aspirin Bacillus Prostaglandin Microbe
This work was in part supported by the Dutch Digestive Diseases Foundation (MLDS; project WO 10–53). BED and AB were supported by a Dutch Science Foundation (NWO) Veni (016•111•075) and Rubicon (825•11•031) grant, respectively.
- Newman JV, Kosaka T, Sheppard BJ, Fox JG, & Schauer DB. Bacterial infection promotes colon tumorigenesis in Apc(Min/+) mice. J Infect Dis. 2001;184(2):227–230. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11424022.
- Taketo MM, Edelmann W. Mouse models of colon cancer. Gastroenterology, 2009;136(3):780–798. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19263594.
- Toprak NU, Yagci A, Gulluoglu BM, Akin ML, Demirkalem P, Celenk T, & Soyletir G. A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer. Clin Microbiol Infect, 2006;12(8):782–786. doi:10.1111/j.1469-0691.2006.01494.x.Google Scholar