Definition
MetaBin: Taxonomic binning of metagenomic sequences.
Introduction
The first, and primary, challenge in metagenomic data analysis is to ascertain the genomic origin of metagenomic sequences and to make appropriate taxonomic assignments (Tringe and Rubin 2005; McHardy et al. 2007; Sharma et al. 2012). Composition- or homology-based classification of metagenomic sequences are the two main approaches that are currently used (McHardy et al. 2007; Huson et al. 2007). Among the two, homology-based methods are more sensitive and accurate but require a large amount of time to generate the BLAST alignments, which are used as an input for these programs. The composition-based approach is exploited by classification tools such as PhyloPythia, TETRA, and TACOA, for taxonomic classification of metagenomic sequences (Diaz et al. 2009; McHardy et al. 2007; Teeling et al. 2004). These methods require prior training...
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References
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Sharma, V.K., Taylor, T.D. (2013). MetaBin. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_735-2
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DOI: https://doi.org/10.1007/978-1-4614-6418-1_735-2
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