Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

Novel Approaches to Pathogen Discovery in Metagenomes

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_732-2



Pathogen discovery: identification of causative microbial or viral agent(s) for an illness or asymptomatic infection. The identification may refer to etiological diagnosis for individuals, epidemiology investigation on population scale, and animal or environmental surveillance on orphan pathogens.

Metagenomics: genomic study on a population of biologically or functionally close microorganisms as a whole community, without separation of components into pure culture isolates.


The best-known statement on pathogen discovery probably is the so-called Koch’s postulates, in which isolation of disease causative microbe and determination of its etiological features are of the essence (Falkow 2004; Lipkin 2010). There are fascinating and tragic stories in medical history of human volunteers or doctors who sacrificed health or even their lives to test pathogens on...


Multiple Displacement Amplification Human Microbiome Project Pathogen Identification Pathogen Discovery Good Data Management 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Viral Diseases BranchWRAIRSilver SpringUSA