Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

CLUSEAN, Overview

  • Tilmann Weber
  • Kai Blin
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_706-4

Synonym

Definition

CLUSEAN, the CLUster SEquence ANalyzer, is a BioPerl-based software pipeline for the annotation of secondary metabolite biosynthetic gene clusters encoding the biosynthesis of molecules with, e.g., antibiotic or anticancer activities. CLUSEAN contains modules for automated homology search, protein domain identification, and, in case of modular polyketide synthases and non-ribosomal peptide synthetases-containing pathways, substrate prediction for the biosynthetic enzymes.

Introduction

A majority of antimicrobials used in human medicine to combat infectious diseases, e.g., tetracycline, penicillin, vancomycin, or erythromycin, many anticancer drugs, and other bioactive molecules, e.g., the immunosuppressant rapamycin, are derived from microbial secondary metabolites, also denoted as natural products. These compounds are mainly synthesized by bacteria and fungi. Traditionally, screening for such compounds is performed by isolating potential...

Keywords

Biosynthetic Gene Cluster Adenylation Domain Secondary Metabolite Gene Cluster Microbial Secondary Metabolite Secondary Metabolite Biosynthetic Gene Cluster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Interfakultäres Institut für Mikrobiologie und Infektionsmedizin Tübingen, Mikrobiologie/BiotechnologieEberhard-Karls UniversitätTübingenGermany