Definition
The types, distribution, and environmental interactions of airway-associated microbial populations in individuals with asthma.
Introduction
The purpose of this entry is to introduce and summarize current knowledge of the airway microbiome in asthma. The relationships between asthma and microbial exposures, colonization, or infection have been postulated and studied for decades (Huang and Lynch 2011; Huang 2013). Although acute respiratory infections can trigger exacerbations of asthma, chronic colonization or infection of the respiratory tract by specific organisms has also been linked to asthma (Martin et al. 2001; Johnston and Martin 2005; Bisgaard et al. 2007). Earlier studies, which have been reviewed recently (Huang and Lynch 2011), used primarily culture methods, serologic antibody assays, or targeted molecular tests to detect exposure to, or infection by, specific microbes. The focus of this entry is to present...
References
Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007;357(15):1487–95.
DeSantis TZ, Brodie EL, Moberg JP, et al. High-density universal 16S rRNA microarray analysis reveals broader diversity than typical clone library when sampling the environment. Microb Ecol. 2007;53(3):371–83.
Han MK, Huang YJ, Lipuma JJ, et al. Significance of the microbiome in obstructive lung disease. Thorax. 2012;67(5):456–63.
Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways. PLoS ONE. 2010;5(1):e8578.
Huang YJ. Asthma microbiome studies and the potential for new therapeutic strategies. Curr Allergy Asthma Rep. 2013;13(5):453–61.
Huang YJ, Lynch SV. The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications. Expert Rev Respir Med. 2011;5(6):809–21.
Huang YJ, Nelson CE, Brodie EL, et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol. 2011;127:372–81. e1–3.
Huang YJ, Charlson ES, Collman RG, et al. The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report. Am J Respir Crit Care Med. 2013;187(12):1382–7.
Johnston SL, Martin RJ. Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis? Am J Respir Crit Care Med. 2005;172(9):1078–89.
Marri PR, Stern DA, Wright AL, et al. Asthma-associated differences in microbial composition of induced sputum. J Allergy Clin Immunol. 2013;131(2):346–52. e3.
Martin RJ, Kraft M, Chu HW, et al. A link between chronic asthma and chronic infection. J Allergy Clin Immunol. 2001;107(4):595–601.
Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–25.
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Huang, Y. (2013). Chronic Respiratory Disease, Asthma. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_699-1
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DOI: https://doi.org/10.1007/978-1-4614-6418-1_699-1
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Publisher Name: Springer, New York, NY
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