Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

Bacteriocin Mining in Metagenomes

  • Orla O’Sullivan
  • Colin Hill
  • Paul Ross
  • Paul Cotter
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_689-3


Bacteriocins are heat-stable ribosomally synthesized peptides produced by one bacterium which are active against other bacteria and against which the producer has a specific immunity mechanism.


Bacteriocins are ribosomally synthesized antimicrobial peptides that are produced by many bacteria and which kill or inhibit the growth of other bacteria. Bacteriocin producers are protected as a consequence of dedicated immunity (self-protective) systems (Cotter et al. 2005). Bacteriocins are of both academic and commercial interest, with several in use as food preservatives or as the active agent in clinical or veterinary antimicrobials. It is not surprising that there is significant interest in the identification and characterization of new bacteriocin gene clusters. The growing volume of metagenomic sequence data is an important resource which can be mined for the in silico discovery of novel bacteriocins.

A Background to Bacteriocins

Bacteriocins were first described...


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Orla O’Sullivan
    • 1
    • 2
  • Colin Hill
    • 2
    • 3
  • Paul Ross
    • 1
    • 2
  • Paul Cotter
    • 1
    • 2
  1. 1.Teagasc Food Research Centre, Moorepark, Fermoy, Co.CorkIreland
  2. 2.Alimentary Pharmabiotic CentreUniversity CollegeCorkIreland
  3. 3.Department of MicrobiologyUniversity CollegeCorkIreland