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Encyclopedia of Metagenomics pp 1–8Cite as

Bacteriocin Mining in Metagenomes

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Definition

Bacteriocins are heat-stable ribosomally synthesized peptides produced by one bacterium which are active against other bacteria and against which the producer has a specific immunity mechanism.

Introduction

Bacteriocins are ribosomally synthesized antimicrobial peptides that are produced by many bacteria and which kill or inhibit the growth of other bacteria. Bacteriocin producers are protected as a consequence of dedicated immunity (self-protective) systems (Cotter et al. 2005). Bacteriocins are of both academic and commercial interest, with several in use as food preservatives or as the active agent in clinical or veterinary antimicrobials. It is not surprising that there is significant interest in the identification and characterization of new bacteriocin gene clusters. The growing volume of metagenomic sequence data is an important resource which can be mined for the in silico discovery of novel bacteriocins.

A Background to Bacteriocins

Bacteriocins were first described...

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Author information

Authors and Affiliations

  1. Teagasc Food Research Centre, Moorepark, Fermoy, Co., Cork, Ireland

    Orla O’Sullivan, Paul Ross & Paul Cotter

  2. Alimentary Pharmabiotic Centre, University College, Cork, Ireland

    Orla O’Sullivan, Colin Hill, Paul Ross & Paul Cotter

  3. Department of Microbiology, University College, Cork, Ireland

    Colin Hill

Authors
  1. Orla O’Sullivan
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  2. Colin Hill
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  3. Paul Ross
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  4. Paul Cotter
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Corresponding author

Correspondence to Orla O’Sullivan .

Editor information

Editors and Affiliations

  1. J. Craig Venter Institute (JCVI), Rockville, Maryland, USA

    Karen E. Nelson

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© 2013 Springer Science+Business Media New York

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O’Sullivan, O., Hill, C., Ross, P., Cotter, P. (2013). Bacteriocin Mining in Metagenomes. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_689-3

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  • DOI: https://doi.org/10.1007/978-1-4614-6418-1_689-3

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6418-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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