Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

MRSA/MSSA, Antibiotic Resistance

  • Kristina G. Hulten
  • J. Chase McNeil
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_56-2

Definition

Staphylococcus aureus causes infections in humans ranging from mild to severe disease. The increasing use of antibiotics has resulted in the acquisition and spread of resistance markers among S. aureus strains. Antibiotic resistance can be conferred by point mutations in specific genes, or resistance genes can be carried on conjugative plasmids or bacteriophages and transferred between organisms or even between species.

Introduction

The objective of this review is to give a concise description of Staphylococcus aureus, focusing on the genetic mechanisms of antibiotic resistance relevant to this bacterium. S. aureus is a ubiquitous organism that causes infections in both adults and children. More than 95 % of infections involve the skin and soft tissues; however, invasive infections such as osteomyelitis, septic arthritis, pneumonia, myositis, pyomyositis, and severe sepsis have been associated with significant morbidity and mortality (Kaplan et al. 2009). First described in...

Keywords

Methicillin Resistance Chlorhexidine Gluconate Inducible Clindamycin Resistance Bacterial Cell Wall Peptidoglycan MLSB Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PediatricsBaylor College of MedicineHoustonUSA