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Effect of Crohn’s Disease Risk Alleles on Enteric Microbiota

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Encyclopedia of Metagenomics

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Synonyms

CD; Gut; Intestinal

Introduction

Crohn’s disease (CD) is one of two major chronic inflammatory conditions of the intestinal tract. In contrast to ulcerative colitis (UC) where inflammation is confined to the mucosa of the colon, the transmural inflammation observed in CD can affect any part of the intestine from the mouth to the anus. CD most commonly affects the most distal end of the small bowel (terminal ileum) and the beginning of the colon (Montreal classification L1, location in ileum ± cecum, Satsangi et al. 2006). Culture-independent 16sRNA sequencing techniques have demonstrated alterations in the composition of resident microbes in the human gut in a subset of individuals with inflammatory bowel diseases (IBD) (Frank et al. 2007). These alterations include reduced relative frequency of certain bacterial taxa, such as Faecalibacterium prausnitzii, in both stool and mucosal biopsy samples collected from ileal CD patients compared to patients without CD (Sokol et al. 2008...

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Author information

Authors and Affiliations

  1. Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, 63110, St. Louis, MO, USA

    Ellen Li

  2. University of Colorado, Denver, Denver, CO, USA

    Daniel Frank

  3. University of North Carolina, Charlotte, NC, USA

    R. Balfour Sartor

Authors
  1. Ellen Li
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  2. Daniel Frank
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  3. R. Balfour Sartor
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Corresponding author

Correspondence to Ellen Li .

Editor information

Editors and Affiliations

  1. J. Craig Venter Institute (JCVI), Rockville, Maryland, USA

    Karen E. Nelson

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Li, E., Frank, D., Sartor, R.B. (2013). Effect of Crohn’s Disease Risk Alleles on Enteric Microbiota. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_531-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6418-1_531-1

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  • Online ISBN: 978-1-4614-6418-1

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