Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

MEtaGenome ANalyzer (MEGAN): Metagenomic Expert Resource

  • Daniel H. Huson
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_4-1

Synonyms

Definition

MEGAN is a tool for analyzing metagenomic sequencing data, allowing the user to interactively explore the taxonomic and functional content of a dataset. It also supports the comparison of multiple datasets. The program was originally published in (Huson et al. 2007), and the most recent version was published in (Huson et al. 2011). Written in Java, the program runs on all major operating systems. The program can be downloaded from http://www-ab.informatik.uni-tuebingen.de/software/megan.

Introduction

Metagenomics is the study of uncultured organisms in their native environment using DNA sequencing (Handelsman et al. 1998). In a typical project, DNA (or, in the case of meta-transcriptomics, cDNA reverse-transcribed from RNA) is extracted from an environmental sample and then shotgun sequenced. Once a metagenome dataset of DNA sequencing reads has been generated in this way, the first three main computation challenges are to (1) estimate...

Keywords

Reference Sequence Reference Database Multiple Dataset Taxonomic Analysis NCBI Taxonomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Center for Bioinformatics, Algorithms in BioinformaticsUniversity of TübingenTübingenGermany