Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

Animal Diseases, Applications of Metagenomics

  • Richard IsaacsonEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_18-6

Synonyms

Definition

This entry describes current knowledge about the microbiome of the gastrointestinal tract of animals and its relationship to infectious diseases. It also describes how the microbiome changes during infections.

Introduction

Rene Dubos’ pioneering work on microbial ecology led to the hypothesis that the microbes of mammals living in intimate contact with each other coevolved with animals (Dubos et al. 1965; Yolton and Savage 1976). Dubos stated, “It is to be expected, therefore, that anatomical structures and physiological needs have been determined in part by the microbiota (microbiome) which prevailed during evolutionary development, and that many manifestations of the body at any given time are influenced by the microbiota now present.” Thus, during the coevolution of the microflora and the host, a set of mutualistic or even symbiotic relationships developed between the host and microbes. This hypothesis is...

Keywords

Human Microbiome Project Cellulolytic Bacterium Irritable Bowel Disease Lactobacillus Amylovorus Antibiotic Growth Promoter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Berg RD. The indigenous gastrointestinal microflora. Trends Microbiol. 1996;4(11):430–5.PubMedCrossRefGoogle Scholar
  2. Collier CT, Smiricky-Tjardes MR, et al. Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters. J Anim Sci. 2003;81(12):3035–45.PubMedGoogle Scholar
  3. Dubos R, Schaedler RW, et al. Indigenous, normal, and autochthonous flora of the gastrointestinal tract. J Exp Med. 1965;122:67–76.PubMedCentralPubMedCrossRefGoogle Scholar
  4. Isaacson R, Borewicz K, Kim HB, Vannucci F, Gebhart C, Singer R, Sreevatsan S, Johnson T. Lawsonia interacellularis increases Salmonella enterica levels in the intestines of pigs. Conference of Research Workers in Animal Diseases, 2011:103.Google Scholar
  5. Leser TD, Lindecrona RH, et al. Changes in bacterial community structure in the colon of pigs fed different experimental diets and after infection with Brachyspira hyodysenteriae. Appl Environ Microbiol. 2000;66(8):3290–6.PubMedCentralPubMedCrossRefGoogle Scholar
  6. Leslie M. Immunology. Gut microbes keep rare immune cells in line. Science. 2012;335(6075):1428.PubMedCrossRefGoogle Scholar
  7. Looft T, Johnson TA, et al. In-feed antibiotic effects on the swine intestinal microbiome. Proc Natl Acad Sci. 2012;109:1691–6.PubMedCentralPubMedCrossRefGoogle Scholar
  8. Mazmanian SK, Liu CH, et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122(1):107–18.PubMedCrossRefGoogle Scholar
  9. Peterson J, Garges S, et al. The NIH human microbiome project. Genome Res. 2009;19(12):2317–23.PubMedCentralPubMedCrossRefGoogle Scholar
  10. Rakoff-Nahoum S, Paglino J, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118(2):229–41.PubMedCrossRefGoogle Scholar
  11. Ramotar K, Conly JM, et al. Production of menaquinones by intestinal anaerobes. J Infect Dis. 1984;150(2):213–8.PubMedCrossRefGoogle Scholar
  12. Reeves AE, Theriot CM, et al. The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection. Gut Microbes. 2011;2(3):145–58.PubMedCentralPubMedCrossRefGoogle Scholar
  13. Rettedal E, Vilain S, et al. Alteration of the ileal microbiota of weanling piglets by the growth-promoting antibiotic chlortetracycline. Appl Environ Microbiol. 2009;75(17):5489–95.PubMedCentralPubMedCrossRefGoogle Scholar
  14. Savage DC. Microbial ecology of the gastrointestinal tract. Ann Rev Microbiol. 1977;31:107–33.CrossRefGoogle Scholar
  15. Schmitz JM, Durham CG, et al. Helicobacter felis – associated gastric disease in microbiota-restricted mice. J Histochem Cytochem. 2011;59(9):826–41.PubMedCentralPubMedGoogle Scholar
  16. Shan T, Li L, et al. The fecal virome of pigs on a high-density farm. J Virol. 2011;85(22):11697–708.PubMedCentralPubMedCrossRefGoogle Scholar
  17. Shimada K, Bricknell KS, et al. Deconjugation of bile acids by intestinal bacteria: review of literature and additional studies. J Infect Dis. 1969;119(3):273–81.PubMedCrossRefGoogle Scholar
  18. Suchodolski JS. Companion animals symposium: microbes and gastrointestinal health of dogs and cats. J Anim Sci. 2011;89(5):1520–30.PubMedCrossRefGoogle Scholar
  19. Suchodolski JS, Xenoulis PG, et al. Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease. Vet Microbiol. 2010;142(3–4):394–400.PubMedCrossRefGoogle Scholar
  20. Turnbaugh P, Ley R, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027–31.PubMedCrossRefGoogle Scholar
  21. Yolton D, Savage DC. Influence of certain indigenous gastrointestinal microorganisms on duodenal alkaline phosphatase of mice. Appl Environ Microbiol. 1976;31(6):880–8.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Veterinary and Biomedical SciencesUniversity of MinnesotaSt. PaulUSA