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Manganese Neurotoxicity

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Handbook of Neurotoxicity

Abstract

Over the past years there has been considerable progress in our understanding of manganese (Mn)-induced neurotoxicity and its mechanisms. These studies led to changes in Mn safety assessment around the world. However, manganism continues to represent a health concern, especially considering the recent findings linking manganism to Parkinson’s disease (PD). Animal models have been invaluable in these investigations. Findings from these studies are discussed in this chapter within the context of Mn-induced neurotoxicity mechanisms and its role in the etiology of parkinsonism.

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Acknowledgments

The authors are thankful to the funding grants NIH R01 ES 07331 (MA), INCT-EN, CAPES, CNPq, and FAPERGS (DSA, RLP, VF, and JBTR).

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Authors and Affiliations

  1. Universidade Federal do Pampa, Uruguaiana, RS, Brazil

    Daiana Silva Ávila, Robson Luiz Puntel & Vanderlei Folmer

  2. Universidade Federal de Santa Maria, RS, Brazil

    João Batista Teixeira Rocha

  3. Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

    Ana Paula Marreilha dos Santos

  4. Department of Pediatrics, Vanderbilt University, 1161 21st Ave, Nashville, TN, 37232-8548, USA

    Michael Aschner

  5. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

    Michael Aschner

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  1. Daiana Silva Ávila
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  2. Robson Luiz Puntel
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  3. Vanderlei Folmer
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  4. João Batista Teixeira Rocha
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  5. Ana Paula Marreilha dos Santos
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  6. Michael Aschner
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Correspondence to Daiana Silva Ávila .

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  1. Department of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee, USA

    Richard M. Kostrzewa

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Ávila, D.S., Puntel, R.L., Folmer, V., Rocha, J.B.T., dos Santos, A.P.M., Aschner, M. (2014). Manganese Neurotoxicity. In: Kostrzewa, R. (eds) Handbook of Neurotoxicity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5836-4_3

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