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Dementia and Alzheimer Disease: Evidence-Based Neuroimaging

  • Juan E. Gutierrez
  • Brian Eichinger
  • Kejal Kantarci
Reference work entry
Part of the Evidence-Based Imaging book series (Evidence-Based Imag.)

Abstract

AD is a progressive neurodegenerative dementia. The pathological hallmarks of AD are accumulation of neurofibrillary tangles and senile plaques. The neurofibrillary pathology, which is associated with cognitive dysfunction, neuron, and synapse loss, involves the limbic cortex early in the disease course and extends to the neocortex as the disease progresses. In addition to the histopathological changes, there is a gradual loss of cholinergic innervation in AD, which has been the basis for cholinesterase inhibitor therapy.

Keywords

Moderate Evidence Normal Pressure Hydrocephalus Cholinergic Innervation Synapse Loss Limbic Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Juan E. Gutierrez
    • 1
  • Brian Eichinger
    • 1
  • Kejal Kantarci
    • 2
  1. 1.Department of RadiologyUniversity of Texas, Health Science Center at San AntonioSan AntonioUSA
  2. 2.Division of Neuroradiology, Department of RadiologyMayo ClinicRochesterUSA

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