Abstract
This chapter focuses on the imaging of acute ischemic stroke patients within the first hours after stroke onset when the decision to administer thrombolytics is of paramount importance. The major goals of imaging during this hyperacute phase of ischemia include: 1. The exclusion of intracerebral hemorrhage for thrombolysis; 2. The detection of acute ischemia in order to exclude stroke mimics; 3. Emerging advanced imaging techniques to delineate ischemic but viable tissue for possible intervention beyond the current thrombolytic window; and 4. the imaging of pediatric acute stroke patients. The chapter provides an in-depth discussion of the literature supporting the use of specific modalities for each of the major goals listed. Finally, imaging case studies and an example of an acute stroke protocol are provided.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
American Heart Association. Heart disease and stroke statistics update at-a-glance. Dallas, TX: AHA; 2010.
Bogousslavsky J, Van Melle G, Regli F. Stroke. 1988;19(9):1083–92.
Roger VL, et al. Circulation. 123(4):e18–e209.
American Heart Association. Heart disease and stroke statistics update. Dallas, TX: AHA; 2004.
Report, M.A.M.W., Centers for Disease Control and Prevention/National Center for Health Statistics. 2001;50(7).
Sacco RL, et al. Am J Epidemiol. 1998;147(3):259–68.
NINDS. N Engl J Med. 1995;333(24):1581–7.
Qureshi AI, et al. Neurosurgery. 2005;57(4):647–54; discussion 647–54.
Kleindorfer D, et al. Stroke. 2008;39(3):924–8.
Kleindorfer D, et al. Stroke. 2009;40(11):3580–4.
Diringer MN, et al. Stroke. 1999;30(4):724–8.
Young KC, Benesch CG, Jahromi BS. Neurology. 2010;75(19):1678–85.
Earnshaw SR, et al. Stroke. 2009;40(5):1710–20.
Jackson D, et al. AJNR Am J Neuroradiol. 2010;31(9):1669–74.
Hacke W, et al. N Engl J Med. 2008;359(13):1317–29.
Fiebach JB, et al. Stroke. 2004;35(2):502–6.
Chalela JA, et al. Lancet. 2007;369(9558):293–8.
New PF, Aronow S. Radiology. 1976;121(3 Pt. 1):635–40.
Culebras A, et al. Stroke. 1997;28(7):1480–97.
Beauchamp Jr NJ, et al. Radiology. 1999;212(2):307–24.
Paxton R, Ambrose J. Br J Radiol. 1974;47(561):530–65.
Jacobs L, Kinkel WR, Heffner Jr RR. Neurology. 1976;26(12):1111–8.
Adams Jr HP, et al. Neurology. 1983;33(8):981–8.
van der Wee N, et al. J Neurol Neurosurg Psychiatry. 1995;58(3):357–9.
Sames TA, et al. Acad Emerg Med. 1996;3(1):16–20.
Sidman R, Connolly E, Lemke T. Acad Emerg Med. 1996;3(9):827–31.
Bradley Jr WG. Radiology. 1993;189(1):15–26.
Gomori JM, et al. Radiology. 1985;157(1):87–93.
Edelman RR, et al. AJNR Am J Neuroradiol. 1986;7(5):751–6.
Thulborn K, Atlas S. Intracranial hemorrhage. New York: Raven; 1991.
Schellinger PD, et al. Stroke. 1999;30(4):765–8.
Patel MR, Edelman RR, Warach S. Stroke. 1996;27(12):2321–4.
Kidwell CS, et al. JAMA. 2004;292(15):1823–30.
Wycliffe ND, et al. Magn Reson Imaging. 2004;20(3):372–7.
Nandigam RN, et al. AJNR Am J Neuroradiol. 2009;30(2):338–43.
Fiehler J, et al. Stroke. 2007;38(10):2738–44.
Lee SH, et al. J Neurol Neurosurg Psychiatry. 2008;79(8):913–6.
Kakuda W, et al. Neurology. 2005;65(8):1175–8.
Lees KR, et al. Lancet. 375(9727):1695–703.
Libman RB, et al. Arch Neurol. 1995;52(11):1119–22.
Norris JW, Hachinski VC. Lancet. 1982;1(8267):328–31.
Kothari RU, et al. Stroke. 1995;26(12):2238–41.
Truwit CL, et al. Radiology. 1990;176(3):801–6.
Tomura N, et al. Radiology. 1988;168(2):463–7.
Patel SC, et al. JAMA. 2001;286(22):2830–8.
von Kummer R, et al. AJNR Am J Neuroradiol. 1994;15(1):9–15; discussion 16–8.
Schriger DL, et al. JAMA. 1998;279(16):1293–7.
Grotta JC, et al. Stroke. 1999;30(8):1528–33.
Hacke W, et al. JAMA. 1995;274(13):1017–25.
Toni D, et al. Neurology. 1996;46(2):341–5.
Larrue V, et al. Stroke. 1997;28(5):957–60.
Larrue V, et al. Stroke, Radiology. 1997;205(2):327–33.
von Kummer R, et al. Acute stroke: usefulness of early CT findings before thrombolytic therapy, Radiology. 1997;205(2):327–33.
Furlan A, et al. JAMA. 1999;282(21):2003–11.
Barber PA, et al. Lancet. 2000;355(9216):1670–4.
Puetz V, et al. Int J Stroke. 2009;4(5):354–64.
Dzialowski I, et al. Stroke. 2006;37(4):973–8.
Kucharczyk J, et al. Diffusion/perfusion MR imaging of acute cerebral ischemia. Magn Reson Med. 1991;19(2):311–5.
Reith W, et al. Neurology. 1995;45(1):172–7.
Mintorovitch J, et al. Magn Reson Med. 1991;18(1):39–50.
Warach S, et al. Ann Neurol. 1995;37(2):231–41.
Moseley ME, et al. Magn Reson Med. 1990;14(2):330–46.
Hoehn-Berlage M, et al. J Cereb Blood Flow Metab. 1995;15(6):1002–11.
Warach S, Boska M, Stroke KM. 1997;28(3):481–2.
Gonzalez RG, et al. Radiology. 1999;210(1):155–62.
Lovblad KO, et al. AJNR Am J Neuroradiol. 1998;19(6):1061–6.
Fiebach JB, et al. Stroke. 2002;33(9):2206–10.
Marks MP, et al. Radiology. 1996;199(2):403–8.
Kidwell CS, et al. Stroke. 1999;30(6):1174–80.
Ay H, et al. Neurology. 1999;52(9):1784–92.
An H, et al. Stroke. 2011;42(5):1276–81.
Ebisu T, et al. Magn Reson Imaging. 1996;14(9):1113–6.
Ohta K, et al. J Neurol. 1999;246(8):736–8.
Sener RN. Comput Med Imaging Graph. 2001;25(5):391–7.
Bahn MM, et al. Arch Neurol. 1997;54(11):1411–5.
Gauvain KM, et al. AJR Am J Roentgenol. 2001;177(2):449–54.
Chen S, et al. AJNR Am J Neuroradiol. 2001;22(6):1089–96.
Chu K, et al. Arch Neurol. 2001;58(6):993–8.
Hasegawa Y, et al. Stroke. 1996;27(9):1648–55; discussion 1655–6.
Linfante I, et al. Arch Neurol. 2001;58(4):621–8.
Warach S, et al. Ann Neurol. 2000;48(5):713–22.
Tong DC, et al. Neurology. 1998;50(4):864–70.
Lovblad KO, et al. Ann Neurol. 1997;42(2):164–70.
Wardlaw JM, et al. Stroke. 2004;35(11):2477–83.
Villringer A, et al. Magn Reson Med. 1988;6(2):164–74.
Rosen BR, et al. Magn Reson Med. 1991;19(2):285–92.
Rosen BR, et al. Magn Reson Med. 1990;14(2):249–65.
Ostergaard L, et al. Magn Reson Med. 1996;36(5):726–36.
Ostergaard L. Cerebral perfusion imaging by bolus tracking. Top Magn Reson Imaging. 2004;15(1):3–9.
van Laar PJ, van der Grond J, Hendrikse J. Radiology. 2008;246(2):354–64.
Astrup J, Siesjo BK, Symon L. Stroke. 1981;12(6):723–5.
Baird AE, et al. Ann Neurol. 1997;41(5):581–9.
Beaulieu C, et al. Ann Neurol. 1999;46(4):568–78.
Davis SM, et al. Lancet Neurol. 2008;7(4):299–309.
Perkins CJ, et al. Stroke. 2001;32(12):2774–81.
Albers GW, et al. Ann Neurol. 2006;60(5):508–17.
Clark WM, et al. Neurology. 2001;57(9):1595–602.
Uno M, et al. Neurosurgery. 2002;50(1):28–34; discussion 34–5.
Minematsu K, et al. Stroke. 1992;23(9):1304–10; discussion 1310–1.
Hasegawa Y, et al. Neurology. 1994;44(8):1484–90.
Kidwell CS, et al. Ann Neurol. 2000;47(4):462–9.
Fiehler J, et al. Stroke. 2002;33(1):79–86.
Chemmanam T, et al. Neurology. 75(12):1040–7.
Takasawa M, et al. Stroke. 2008;39(3):870–7.
Olivot JM, et al. Stroke. 2009;40(2):469–75.
Kane I, et al. Stroke. 2007;38(12):3158–64.
Olivot JM, et al. Neurology. 2009;72(13):1140–5.
Butcher KS, et al. Stroke. 2005;36(6):1153–9.
Sobesky J, et al. Stroke. 2004;35(12):2843–7.
Christensen S, et al. Stroke. 2009;40(6):2055–61.
Hacke W, et al. Stroke. 2005;36(1):66–73.
Hacke W, et al. Lancet Neurol. 2009;8(2):141–50.
Barker PB, et al. Radiology. 1994;192(3):723–32.
Grohn OH, Kauppinen RA. NMR Biomed. 2001;14(7–8):432–40.
Decanniere C, et al. Magn Reson Med. 1995;34(3):343–52.
Bizzi A, et al. Magn Reson Imaging. 1996;14(6):581–92.
Sager TN, Laursen H, Hansen AJ. J Cereb Blood Flow Metab. 1995;15(4):639–46.
Munoz Maniega S, et al. Neurology. 2008;71(24):1993–9.
Cvoro V, et al. Stroke. 2009;40(3):767–72.
Lee JM, et al. Ann Neurol. 2003;53(2):227–32.
Powers WJ, et al. J Cereb Blood Flow Metab. 1985;5(4):600–8.
Baron JC. Cerebrovasc Dis. 1999;9(4):193–201.
Diekmann S, et al. AJNR Am J Neuroradiol. 2010;31(6):1003–9.
Gur D, et al. Science. 1982;215(4537):1267–8.
Wolfson Jr SK, et al. Stroke. 1990;21(5):751–7.
DeWitt DS, et al. Stroke. 1989;20(12):1716–23.
Firlik AD, et al. Stroke. 1997;28(11):2208–13.
Firlik AD, et al. J Neurosurg. 1998;89(2):243–9.
Plougmann J, et al. J Neurosurg. 1994;81(6):822–8.
Wintermark M, et al. Stroke. 2006;37(4):979–85.
Mayer TE, et al. AJNR Am J Neuroradiol. 2000;21(8):1441–9.
Bivard A, et al. Cerebrovasc Dis. 2011;31(3):238–45.
Campbell B, et al. Predicting infarct core using CT perfusion: comparison of CT perfusion parameters to concurrent diffusion MRI. In: International stroke conference; 2011: Los Angeles.
Baron JC, et al. J Cereb Blood Flow Metab. 1989;9(6):723–42.
Baron JC, et al. Stroke. 1981;12(4):454–9.
Powers RH, et al. Cancer Res. 1992;52(7):1699–703.
Wise RJ, et al. Brain. 1983;106(Pt 1):197–222.
Heiss WD, et al. J Cereb Blood Flow Metab. 1992;12(2):193–203.
Furlan M, et al. Ann Neurol. 1996;40(2):216–26.
Markus R, et al. Brain. 2004;127(Pt 6):1427–36.
Heiss WD, et al. J Cereb Blood Flow Metab. 1998;18(12):1298–307.
Khatri P, et al. Int J Stroke. 2008;3(2):130–7.
Koelemay MJ, et al. Stroke. 2004;35(10):2306–12.
Hirai T, et al. AJNR Am J Neuroradiol. 2002;23(1):93–101.
Katz DA, et al. Radiology. 1995;195(2):445–9.
Knauth M, et al. AJNR Am J Neuroradiol. 1997;18(6):1001–10.
Shrier DA, et al. AJNR Am J Neuroradiol. 1997;18(6):1011–20.
Wildermuth S, et al. Stroke. 1998;29(5):935–8.
Verro P, et al. Stroke. 2002;33(1):276–8.
Graf J, et al. J Neurol. 2000;247(10):760–6.
Nguyen-Huynh MN, et al. Stroke. 2008;39(4):1184–8.
Bash S, et al. AJNR Am J Neuroradiol. 2005;26(5):1012–21.
Wardlaw JM, et al. Lancet. 2006;367(9521):1503–12.
Liberopoulos K, et al. Int Angiol. 1996;15(2):131–7.
Khan S, et al. Stroke. 2009;40(11):3499–503.
Cloft HJ, et al. Magn Reson Imaging. 1996;14(6):593–600.
Willig DS, et al. Radiology. 1998;208(2):447–51.
Feldmann E, et al. Neurology. 2007;68(24):2099–106.
Lynch JK, et al. Pediatrics. 2002;109(1):116–23.
Agrawal N, et al. Stroke. 2009;40(11):3415–21.
Kirkham FJ, et al. J Child Neurol. 2000;15(5):299–307.
Jordan LC, Hillis AE. Nat Rev Neurol. 2011;7(4):199–208.
Amlie-Lefond C, et al. Neuroepidemiology. 2009;32(4):279–86.
Srinivasan J, et al. Pediatrics. 2009;124(2):e227–34.
Chabrier S, et al. Thromb Res. 2011;127(1):13–22.
Cowan F, et al. Arch Dis Child Fetal Neonatal Ed. 2005;90(3):F252–6.
Dudink J, et al. AJNR Am J Neuroradiol. 2009;30(5):998–1004.
Husson B, et al. Pediatrics. 2010;126(4):912–8.
Adams RJ, Brambilla D. N Engl J Med. 2005;353(26):2769–78.
Adams RJ, et al. N Engl J Med. 1998;339(1):5–11.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this entry
Cite this entry
Ford, A.L., Lee, JM., Lin, W., Vo, K.D. (2013). Acute Ischemic Stroke: Evidence-Based Neuroimaging. In: Medina, L.S., Sanelli, P.C., Jarvik, J.G. (eds) Evidence-Based Neuroimaging Diagnosis and Treatment. Evidence-Based Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3320-0_11
Download citation
DOI: https://doi.org/10.1007/978-1-4614-3320-0_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-3319-4
Online ISBN: 978-1-4614-3320-0
eBook Packages: MedicineReference Module Medicine