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Precancerous Lesions of the Cervix

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Blaustein's Pathology of the Female Genital Tract

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Abstract

This chapter covers the epidemiology, pathogenesis, current nomenclature, and histological appearances of precancerous lesions of the cervix. For over 20 years, it has been evident that specific types of human papillomavirus (HPV) cause almost all squamous cell carcinomas of the cervix as well as the vast majority of adenocarcinomas of the cervix. However, much remains to be learned regarding the precise molecular pathways by which these DNA tumor viruses produce tumors and why only a small minority of HPV- infected individuals develop disease. The chapter discusses the current terminology used to refer to precancerous lesions including both squamous and glandular lesions. The chapter then provides an in- depth description of the histological features of both squamous intraepithelial lesions and glandular neoplasia. This includes both their differential diagnoses and the use of adjunctive histological methods including p16.

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Authors and Affiliations

  1. Department of Pathology and Cell Biology, Columbia University, New York, NY, USA

    Thomas C. Wright

  2. Department of Pathology, Division of Gynecologic Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Brigitte M. Ronnett

  3. Departments of Gynecology, Obstetrics, Pathology and Oncology, Division of Gynecologic Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Robert J. Kurman

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  1. Thomas C. Wright
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  3. Robert J. Kurman
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Correspondence to Thomas C. Wright .

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Editors and Affiliations

  1. Johns Hopkins University Dept. Gynecology, Obstetrics & Pathology, Baltimore, MD, USA

    Robert J. Kurman

  2. Dept. Urology, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY, USA

    Lora Hedrick Ellenson

  3. Johns Hopkins University Dept. Gynecology, Obstetrics & Pathology, Baltimore, MD, USA

    Brigitte M. Ronnett

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Wright, T.C., Ronnett, B.M., Kurman, R.J. (2018). Precancerous Lesions of the Cervix. In: Kurman, R., Hedrick Ellenson, L., Ronnett, B. (eds) Blaustein's Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3165-7_5-2

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