Metastatic Tumors of the Ovary

  • Melinda F. LerwillEmail author
  • Robert H. Young
Living reference work entry


While commonest as an autopsy finding, tumors that spread to the ovary are not rare in surgical pathology specimens and their misinterpretation may have significant adverse consequences for the patient. They may spread from adjacent sites by direct local extension or from distant extragenital sites. The latter tumors are truly metastatic, whereas the designation “metastatic” is sometimes not used for those that are secondary from local sites. For simplicity this discussion includes spread to the ovary from all sites.


  1. Abdul-Hafeez M, Akhtar M, Aqeel HSB, Kidess EA (1987) Placental site trophoblastic tumor: report of a case with review of literature. Ann Saudi Med 7:340–344CrossRefGoogle Scholar
  2. Acosta-Sison H (1958) The relative frequency of various anatomic sites as the point of first metastasis in 32 cases of chorionepithelioma. Am J Obstet Gynecol 75:1149–1152PubMedCrossRefPubMedCentralGoogle Scholar
  3. Agoff SN, Lamps LW, Philip AT, Amin MB, Schmidt RA, True LD, Folpe AL (2000) Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 13:238–242PubMedCrossRefPubMedCentralGoogle Scholar
  4. Alvarado-Cabrero I, Rodríguez-Gómez A, Castelan-Pedraza J, Valencia-Cedillo R (2013) Metastatic ovarian tumors. A clinicopathologic study of 140 cases. Anal Quant Cytopathol Histopathol 35:241–248Google Scholar
  5. Amorn Y, Knight WA (1978) Primary linitis plastica of the colon: report of two cases and review of the literature. Cancer (Phila) 41:2420–2425CrossRefGoogle Scholar
  6. Anglesio MS, Wang YK, Maassen M, Horlings HM, Bashashati A, Senz J, Mackenzie R, Grewal DS, Li-Chang H, Karnezis AN, Sheffield BS, McConechy MK, Kommoss F, Taran FA, Staebler A, Shah SP, Wallwiener D, Brucker S, Gilks CB, Kommoss S, Huntsman DG (2016) Synchronous endometrial and ovarian carcinomas: evidence of clonality. J Natl Cancer Inst 108:djv428.
  7. Baker PM, Oliva E (2004) Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol 24:39–55Google Scholar
  8. Baker PM, Clement PB, Young RH (2005) Malignant peritoneal mesothelioma in women. A study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. Am J Clin Pathol 123:724–737PubMedCrossRefPubMedCentralGoogle Scholar
  9. Beck RP, Latour JPA (1963) Necropsy reports on 36 cases of endometrial carcinoma. Am J Obstet Gynecol 85:307–311PubMedCrossRefPubMedCentralGoogle Scholar
  10. Bennett JA, Young RH, Chuang AY, Lerwill MF (2017) Ovarian metastases of breast cancers with signet ring cells: a report of 17 cases including 14 Krukenberg tumors. Int J Gynecol Pathol (in press).
  11. Berg KB, Schaeffer DF (2017) SATB2 as an immunohistochemical marker for colorectal adenocarcinoma. A concise review of benefits and pitfalls. Arch Pathol Lab Med 141:1428–1433PubMedCrossRefPubMedCentralGoogle Scholar
  12. Birnkrant A, Sampson J, Sugarbaker PH (1986) Ovarian metastasis from colorectal cancer. Dis Colon Rectum 29:767–771PubMedCrossRefPubMedCentralGoogle Scholar
  13. Bombonati A, Lerwill MF (2012) Metastases to and from the breast. Surg Pathol Clin 5:179–747CrossRefGoogle Scholar
  14. Brogioni S, Viacava P, Tomisti L, Martino E, Macchia E (2007) A special case of bilateral metastases in a woman with papillary carcinoma of the thyroid. Exp Clin Endocrinol Diabetes 115:397–400PubMedCrossRefPubMedCentralGoogle Scholar
  15. Brown BL, Scharifker DA, Gordon R, Deppe GG, Cohen CJ (1980) Bronchial carcinoid tumor with ovarian metastasis. A light microscopic and ultrastructural study. Cancer 46:543–546PubMedCrossRefPubMedCentralGoogle Scholar
  16. Bullon A, Arseneau J, Prat J, Young RH, Scully RE (1981) Tubular Krukenberg tumor. A problem in histopathologic diagnosis. Am J Surg Pathol 5:225–232PubMedCrossRefPubMedCentralGoogle Scholar
  17. Bunker ML (1959) The terminal findings in endometrial carcinoma. Am J Obstet Gynecol 77:530–538PubMedCrossRefPubMedCentralGoogle Scholar
  18. Byrne DJ, Deb S, Takano EA, Fox SB (2017) GATA3 expression in triple-negative breast cancers. Histopathol 71:63–71CrossRefGoogle Scholar
  19. Cameron RI, Ashe P, O’Rourke DM, Foster H, McCluggage WG (2003) A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 22:272–276PubMedCrossRefPubMedCentralGoogle Scholar
  20. Cao D, Ji H, Ronnett BM (2004) Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas of the ovary. Int J Gynecol Pathol 24:67–72Google Scholar
  21. Carlson JW, Nucci MR, Brodsky J, Crum CP, Hirsch MS (2007) Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. Histopathology 51:305–312PubMedCrossRefPubMedCentralGoogle Scholar
  22. Caron P, Roche H, Gorguet B, Martel P, Bennet A, Carton M (1990) Mammary ovarian metastases with stromal cell hyperplasia and postmenopausal virilization. Cancer (Phila) 66:1221–1224CrossRefGoogle Scholar
  23. Chapel DB, Husain AN, Krausz T, McGregor SM (2017) PAX8 expression in a subset of malignant peritoneal mesotheliomas and benign mesothelium has diagnostic implications in the differential diagnosis of ovarian serous carcinoma. Am J Surg Pathol 41:1675–1682PubMedCrossRefPubMedCentralGoogle Scholar
  24. Che M, Tornos C, Deavers MT (2001) Ovarian mixed-epithelial carcinomas with a microcystic pattern and signet-ring cells. Int J Gynecol Pathol 20:323–328PubMedCrossRefPubMedCentralGoogle Scholar
  25. Chen ZME, Wang HL (2004) Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. Am J Surg Pathol 28:1352–1359PubMedCrossRefPubMedCentralGoogle Scholar
  26. Clement PB, Young RH, Scully RE (1996) Malignant mesotheliomas presenting as ovarian masses. A report of nine cases, including two primary ovarian mesotheliomas. Am J Surg Pathol 20:1067–1080PubMedCrossRefPubMedCentralGoogle Scholar
  27. Creasman WT, Lukeman J (1972) Role of the fallopian tube in dissemination of malignant cells in corpus cancer. Cancer (Phila) 20:456–457CrossRefGoogle Scholar
  28. DeCostanzo DC, Elias JM, Chumas JC (1997) Necrosis in 84 ovarian carcinomas: a morphologic study of primary versus metastatic colonic cancer with a selective immunohistochemical analysis of cytokeratin subtypes and carcinoembryonic antigen. Int J Gynecol Pathol 16:245–249PubMedCrossRefPubMedCentralGoogle Scholar
  29. Desouki MM, Lioyd J, Xu H, Cao D, Barner R, Zhao C (2013) CDX2 may be a useful marker to distinguish primary ovarian carcinoid from gastrointestinal metastatic carcinoids to the ovary. Hum Pathol 44:2536–2541PubMedCrossRefPubMedCentralGoogle Scholar
  30. DiLoreto C, Di Lauro V, Puglisi F et al (1997) Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol 50:30–32CrossRefGoogle Scholar
  31. Eichhorn JH, Young RH, Scully RE (1993) Non-pulmonary small cell carcinomas of extragenital origin metastatic to the ovary: a report of seven cases. Cancer (Phila) 71:177–186CrossRefGoogle Scholar
  32. Eifel P, Hendrickson M, Ross J, Ballon S, Martinez A, Kempson R (1982) Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer (Phila) 50:163–170CrossRefGoogle Scholar
  33. Elhajj M, Mazurka J, Daya D (2002) Desmoplastic small round cell tumor presenting in the ovaries: report of a case and review of the literature. Int J Gynecol Cancer 12:760–763PubMedCrossRefPubMedCentralGoogle Scholar
  34. Elishaev E, Gilks CB, Miller D, Srodon M, Kurman RJ, Ronnett BM (2005) Synchronous and metachronous endocervical and ovarian neoplasms. Evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. Am J Surg Pathol 29:281–294PubMedCrossRefPubMedCentralGoogle Scholar
  35. Fitzgibbons PL, Martin SE, Simmons TJ (1987) Malignant melanoma metastatic to the ovary. Am J Surg Pathol 11:959–964PubMedCrossRefPubMedCentralGoogle Scholar
  36. Gagnon Y, Tetu B (1989) Ovarian metastases of breast carcinoma. A clinicopathologic study of 59 cases. Cancer (Phila) 64:892–898CrossRefGoogle Scholar
  37. Gilks CB, Kommoss F (2018) Synchronous tumors of the female reproductive tract. Pathol 50:214–221CrossRefGoogle Scholar
  38. Gill AJ, Chou A, Vilain R, Clarkson A, Lui M, Jin R, Tobias V, Samra J, Goldstein D, Smith C, Sioson L, Parker N, Smith RC, Sywak M, Sidhu SB, Wyatt JM, Robinson BG, Eckstein RP, Benn DE, Clifton-Bligh RJ (2010) Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types. Am J Surg Pathol 34:636–644PubMedPubMedCentralGoogle Scholar
  39. Giordano G, Cruz Viruel N, Silini EM, Nogales FF (2017) Adenocarcinoma of the lung metastatic to the ovary with a signet ring cell component. Int J Surg Pathol 25:365–367PubMedCrossRefPubMedCentralGoogle Scholar
  40. Gokden N, Gokden M, Phan DC, McKenney JK (2008) The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics. An immunohistochemical study with comparison to renal cell carcinoma marker. Am J Surg Pathol 32:1462–1467PubMedCrossRefPubMedCentralGoogle Scholar
  41. Goldblum J, Hart WR (1995) Localized and diffuse mesotheliomas of the genital tract and peritoneum in women. A clinicopathological study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas and localized fibrous tumors. Am J Surg Pathol 19:1124–1137PubMedCrossRefPubMedCentralGoogle Scholar
  42. Graffner HOL, Alm POA, Oscarson JEA (1983) Prophylactic oophorectomy in colorectal carcinoma. Am J Surg 146:233–235PubMedCrossRefPubMedCentralGoogle Scholar
  43. Green LK, Silva EG (1989) Hepatoblastoma in an adult with metastasis to the ovaries. Am J Clin Pathol 92:110–115PubMedCrossRefPubMedCentralGoogle Scholar
  44. Gupta D, Deavers MT, Silva EG et al (2004) Malignant melanoma involving the ovary. A clinicopathologic and immunohistochemical study of 23 cases. Am J Surg Pathol 28:771–780PubMedCrossRefPubMedCentralGoogle Scholar
  45. Hagemann IS, Pfeifer JD, Cao D (2013) Mammaglobin expression in gynecologic adenocarcinomas. Hum Pathol 44:628–635PubMedCrossRefPubMedCentralGoogle Scholar
  46. Hale RW (1968) Krukenberg tumor of the ovaries. A review of 81 records. Obstet Gynecol 32:221–225PubMedPubMedCentralGoogle Scholar
  47. Harris M, Howell A, Chrissohou M, Swindell RIC, Hudson M, Sellwood RA (1984) A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer 50:23–30PubMedPubMedCentralCrossRefGoogle Scholar
  48. Hayashi Y, Kikuchi F, Oka T et al (1988) Rhabdomyosarcoma with bone marrow metastasis simulating acute leukemia. Report of two cases. Acta Pathol Jpn 38:789–798PubMedPubMedCentralGoogle Scholar
  49. Hecht JL, Pinkus JL, Weinstein LJ et al (2001) The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin. Am J Clin Pathol 116:483–488PubMedCrossRefPubMedCentralGoogle Scholar
  50. Holtz F, Hart WR (1982) Krukenberg tumors of the ovary. A clinicopathologic analysis of 27 cases. Cancer (Phila) 50:2438–2447CrossRefGoogle Scholar
  51. Hopping RA, Dockerty MB, Masson JC (1942) Carcinoid tumor of the appendix. Report of a case in which extensive intra-abdominal metastases occurred, including involvement of the right ovary. Arch Surg 45:613–622CrossRefGoogle Scholar
  52. Hristov AC, Young RH, Vang R, Yemelyanova AV, Seidman JD, Ronnett BM (2007) Ovarian metastases of appendiceal tumors with goblet cell carcinoid-like and signet ring cell patterns: a report of 30 cases. Am J Surg Pathol 31:1502–1511PubMedCrossRefPubMedCentralGoogle Scholar
  53. Hsiu J-G, Kemp GM, Singer GA, Rawls WH, Siddiky MA (1991) Transitional cell carcinoma of the renal pelvis with ovarian metastasis. Gynecol Oncol 41:178–181PubMedCrossRefPubMedCentralGoogle Scholar
  54. Insabato L, DeRosa G, Franco R et al (2003) Ovarian metastasis from renal cell carcinoma: a report of three cases. Int J Surg Pathol 11:309–312PubMedCrossRefPubMedCentralGoogle Scholar
  55. Irving JA, Young RH (2005) Lung carcinoma metastatic of the ovary. A clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis. Am J Surg Pathol 29:997–1006PubMedPubMedCentralGoogle Scholar
  56. Irving JA, Lerwill MF, Young RH (2005) Gastrointestinal stromal tumors metastatic to the ovary. A report of five cases. Am J Surg Pathol 29:920–926PubMedCrossRefPubMedCentralGoogle Scholar
  57. Irving JA, Vasques DR, McGuinness TB, Young RH (2006) Krukenberg tumor of renal pelvic origin: report of a case with selected comments on ovarian tumors metastatic from the urinary tract. Int J Gynecol Pathol 25:147–150PubMedCrossRefPubMedCentralGoogle Scholar
  58. Ji H, Isacson C, Seidman JD, Kurman RJ, Ronnett BM (2002) Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas. Int J Gynecol Pathol 21:391–400PubMedCrossRefPubMedCentralGoogle Scholar
  59. Judson K, McCormick C, Vang R, Yemelyanova AV, Wu LSF, Bristow RE, Ronnett BM (2008) Women with undiagnosed colorectal adenocarcinomas presenting with ovarian metastases: Clinicopathologic features and comparison with women having known colorectal adenocarcinomas and ovarian involvement. Int J Gynecol Pathol 27:182–190PubMedPubMedCentralGoogle Scholar
  60. Kaminski PF, Norris HJ (1984) Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol 64:553–556PubMedPubMedCentralGoogle Scholar
  61. Kandalaft PL, Gown AM, Isacson C (2014) The lung-restricted marker napsin a is highly expressed in clear cell carcinomas of the ovary. Am J Clin Pathol 142:830–836PubMedCrossRefPubMedCentralGoogle Scholar
  62. Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, Soslow RA, Park KJ (2015) Gastric-type endocervical adenocarcinoma: an aggressive tumor with unusual metastatic patterns and poor prognosis. Am J Surg Pathol 39:1449–1457PubMedPubMedCentralCrossRefGoogle Scholar
  63. Kaufmann O, Dietel M (2000) Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins a and B. Histopathology 36:8–16PubMedCrossRefPubMedCentralGoogle Scholar
  64. Kershisnik MM, Ro JY, Cannon GH, Ordóñez NG, Ayala AG, Silva EG (1995) Histiocytic reaction in pelvic peritoneum associated with oxidized regenerated cellulose. Am J Clin Pathol 103:27–31PubMedCrossRefPubMedCentralGoogle Scholar
  65. Khunamornpong S, Siriaunkgul S, Chunduan A (1999) Metastatic hepatocellular carcinoma of the ovary. Int J Gynecol Obstet 64:189–191CrossRefGoogle Scholar
  66. Khunamornpong S, Suprasert PS, Pojchamarnwiputh S, Chiangmai WN, Settakorn J, Siriaunkgul S (2006a) Primary and metastatic mucinous adenocarcinomas of the ovary: evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol 101:152–157PubMedCrossRefPubMedCentralGoogle Scholar
  67. Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH (2007) Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor of the ovary that may mimic primary neoplasia. Am J Surg Pathol 31:1788–1799PubMedCrossRefPubMedCentralGoogle Scholar
  68. Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH (2008) Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol 27:366–379PubMedCrossRefPubMedCentralGoogle Scholar
  69. Kim K-R, Scully RE (1990) Peritoneal keratin granulomas with carcinomas of endometrium and ovary and atypical polypoid adenomyoma of endometrium. A clinicopathological analysis of 22 cases. Am J Surg Pathol 14:925–932PubMedCrossRefPubMedCentralGoogle Scholar
  70. Kim KR, Lee HI, Lee SK, Ro JY, Robboy SJ (2007) Is stromal microinvasion in primary mucinous ovarian tumors with “mucin granuloma” true invasion? Am J Surg Pathol 31:546–554PubMedCrossRefPubMedCentralGoogle Scholar
  71. Kim CJ, Baruch-Oren T, Lin F, Fan XS, Yang XJ, Wang HL (2016) Value of SATB2 immunostaining in the distinction between small intestinal and colorectal adenocarcinomas. J Clin Pathol 69:1046–1050PubMedCrossRefPubMedCentralGoogle Scholar
  72. Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, Berkowitz RS, Muto MG, Crum CP (2007) Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 31:161–169PubMedCrossRefPubMedCentralGoogle Scholar
  73. Kiyokawa T, Young RH, Scully RE (2006) Krukenberg tumors of the ovary. A clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol 31:277–299CrossRefGoogle Scholar
  74. Kubba LA, McCluggage WG, Liu J, Malpica A, Euscher ED, Silva EG, Deavers MT (2008) Thyroid transcription factor-1 expression in ovarian epithelial neoplasms. Mod Pathol 21:485–490PubMedCrossRefPubMedCentralGoogle Scholar
  75. Kuo T-T, Hsueh S (1984) Mucicarminophilic histiocytosis. A polyvinylpyrrolidone (PVP) storage disease simulating signet-ring cell carcinoma. Am J Surg Pathol 8:419–428PubMedCrossRefPubMedCentralGoogle Scholar
  76. Kurek R, Von Knoblock R, Feek U, Heidenreich A, Hofmann R (2001) Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis. J Urol 166:985PubMedCrossRefPubMedCentralGoogle Scholar
  77. Lash RH, Hart WR (1987) Intestinal adenocarcinomas metastatic to the ovaries. A clinicopathological evaluation of 22 cases. Am J Surg Pathol 11:114–121PubMedCrossRefPubMedCentralGoogle Scholar
  78. Laury AR, Peret R, Piao H, Krane JF, Barletta JA, French C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin R, Hirsch MS (2011) A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol 35:816–826PubMedCrossRefPubMedCentralGoogle Scholar
  79. Lee KR, Young RH (2003) The distinction between primary and metastatic mucinous carcinomas of the ovary. Am J Surg Pathol 2:281–292CrossRefGoogle Scholar
  80. Lee MJ, Lee HS, Kim WH, Choi Y, Yang M (2003) Expressions of mucins and cytokeratins in primary carcinomas of the digestive system. Mod Pathol 16:403–410PubMedCrossRefPubMedCentralGoogle Scholar
  81. Lee AH, Paish EC, Marchio C, Sapino A, Schmitt FC, Ellis IO, Reis-Filho JS (2007) The expression of Wilms’ tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology 51:824–828PubMedCrossRefPubMedCentralGoogle Scholar
  82. Lee S-J, Bae J-H, Lee A-W, Tong S-Y, Park Y-G, Park J-S (2009) Clinical characteristics of metastatic tumors to the ovaries. J Korean Med Sci 24:114–119PubMedPubMedCentralCrossRefGoogle Scholar
  83. Leroy X, Farine MO, Buob D, Wacrenier A, Copin MC (2007) Diagnostic value of cytokeratin 7, CD10 and mesothelin in distinguishing ovarian clear cell carcinoma from metastasis of renal clear cell carcinoma. Histopathology 51:846–876CrossRefGoogle Scholar
  84. Lerwill MF, Young RH (2006) Ovarian metastases of intestinal-type gastric carcinoma. A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor. Am J Surg Pathol 31:1382–1388CrossRefGoogle Scholar
  85. Lewis MR, Deavers MT, Silva EG, Malpica A (2006) Ovarian involvement by metastatic colorectal adenocarcinoma. Still a diagnostic challenge. Am J Surg Pathol 30:177–184PubMedCrossRefPubMedCentralGoogle Scholar
  86. Liang L, Huang H, Dadhania V, Zhang J, Zhang M, Liu J (2016) Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases. Hum Pathol 51:96–102PubMedPubMedCentralCrossRefGoogle Scholar
  87. Logani S, Baloch ZW, Snyder PJ, Weinstein R, LiVolvi VA (2001) Cystic ovarian metastasis from papillary thyroid carcinoma: a case report. Thyroid 11:1073–1075PubMedCrossRefPubMedCentralGoogle Scholar
  88. Logani S, Oliva E, Amin MB, Folpe AL, Cohen C, Young RH (2003) Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers. Histogenic and diagnostic implications. Am J Surg Pathol 27:1434–1441PubMedCrossRefPubMedCentralGoogle Scholar
  89. Logani S, Oliva E, Arnell PM, Amin MB, Young RH (2005) Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. Mod Pathol 18:19–25PubMedCrossRefPubMedCentralGoogle Scholar
  90. Longacre TA, O’Hanlan K, Hendrickson MR (1996) Adenoid cystic carcinoma of the submandibular gland with symptomatic ovarian metastases. Int J Gynecol Pathol 15:349–355PubMedCrossRefPubMedCentralGoogle Scholar
  91. MacKeigan JM, Ferguson JA (1979) Prophylactic oophorectomy and colorectal cancer in premenopausal patients. Dis Colon Rectum 22:401–405PubMedCrossRefPubMedCentralGoogle Scholar
  92. Martin-Hernández R, Mollejo Villanueva M, Navarro Sánchez M, Carabias López E (2015) Ovarian metastasis of a thymoma: report of a case and literature review. Int J Gynecol Pathol 34:374–378PubMedPubMedCentralGoogle Scholar
  93. McCluggage WG (2008) Immunohistochemical markers as a diagnostic aid in ovarian pathology. Diagn Histopathol 14:335–351CrossRefGoogle Scholar
  94. McCluggage WG (2012) Immunohistochemistry in the distinction between primary and metastatic ovarian mucinous neoplasms. J Clin Pathol 65:596–600PubMedCrossRefPubMedCentralGoogle Scholar
  95. McCluggage WG, Wilkinson N (2005) Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features. Histopathology 47:231–247PubMedCrossRefPubMedCentralGoogle Scholar
  96. McCluggage WG, Young RH (2005) Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol 22:3–32PubMedCrossRefPubMedCentralGoogle Scholar
  97. McCluggage WG, Young RH (2008) Primary ovarian mucinous tumors with signet ring cells: report of three cases with discussion of so-called primary Krukenberg tumor. Am J Surg Pathol 32:1373–1379PubMedCrossRefPubMedCentralGoogle Scholar
  98. McCluggage WG, Bissonnette JP, Young RH (2006) Primary malignant melanoma of the ovary: a report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 25:321–329PubMedCrossRefPubMedCentralGoogle Scholar
  99. McKenney JK, Soslow RA, Longacre TA (2008) Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol 32:645–655PubMedCrossRefPubMedCentralGoogle Scholar
  100. Meriden Z, Yemelyanova AV, Vang R, Ronnett BM (2011) Ovarian metastases of pancreaticobiliary tract adenocarcinomas: analysis of 35 cases, with emphasis on the ability of metastases to simulate primary ovarian mucinous tumors. Am J Surg Pathol 35:276–288PubMedCrossRefPubMedCentralGoogle Scholar
  101. Merino MJ, Edmonds P, LiVolsi V (1985) Appendiceal carcinoma metastatic to the ovaries and mimicking primary ovarian tumors. Int J Gynecol Pathol 4:110–120PubMedCrossRefPubMedCentralGoogle Scholar
  102. Mete O, Yeğen G, Güllüoğlu MG, Kapran Y, Klöppel G (2011) An unusual clinical presentation of pancreatic solid pseudopapillary tumor with ovarian metastases: a diagnostic dilemma. Int J Surg Pathol 19:342–345PubMedCrossRefPubMedCentralGoogle Scholar
  103. Meyer WH, Yu GW, Milvenan ES, Jeffs RD, Kaizer H, Leventhal BG (1979) Ovarian involvement in neuroblastoma. Med Pediatr Oncol 7:49–54PubMedCrossRefPubMedCentralGoogle Scholar
  104. Miettinen M, Wang ZF, Lasota J (2009) DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol 33:1401–1408PubMedCrossRefPubMedCentralGoogle Scholar
  105. Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfot R, Waloszczyk P, Biernat W, Lasota J, Wang Z (2014) GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol 38:13–22PubMedPubMedCentralCrossRefGoogle Scholar
  106. Milingos D, Doumplis D, Savage P, Seckl M, Lindsay I, Smith JR (2007) Placental site trophoblastic tumor with an ovarian metastasis. Int J Gynecol Cancer 17:925–927PubMedCrossRefPubMedCentralGoogle Scholar
  107. Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH (2003) Appendiceal mucinous neoplasms. A clinicopathologic analysis of 107 cases. Am J Surg Pathol 27:1089–1103PubMedCrossRefPubMedCentralGoogle Scholar
  108. Mitsushita J, Netsu S, Suzuki K, Nokubi M, Tanaka A (2017) Metastatic ovarian tumors originating from a small bowel adenocarcinoma - a case report and brief literature review. Int J Gynecol Pathol 36:253–260PubMedCrossRefPubMedCentralGoogle Scholar
  109. Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT (2016) SATB2 expression distinguishes ovarian metastases of colorectal and appendiceal origin from primary ovarian tumors of mucinous or endometrioid type. Am J Surg Pathol 40:419–432PubMedCrossRefPubMedCentralGoogle Scholar
  110. Monteagudo C, Merino MJ, Laporte N, Neumann RD (1991) Value of gross cystic disease fluid protein-15 in distinguishing metastatic breast carcinomas among poorly differentiated neoplasms involving the ovary. Hum Pathol 22:368–372PubMedCrossRefPubMedCentralGoogle Scholar
  111. Nonaka D, Chiriboga L, Soslow RA (2008) Expression of Pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol 32:1566–1571PubMedCrossRefPubMedCentralGoogle Scholar
  112. Oberg KC, Wells K, Seraj IM et al (2002) ACTH-secreting islet cell tumor of the pancreas presenting as bilateral ovarian tumors and Cushing’s syndrome. Int J Gynecol Pathol 21:276–280PubMedCrossRefPubMedCentralGoogle Scholar
  113. Ohira S, Shiohara S, Itoh K et al (2003) Urachal adenocarcinoma metastatic to the ovaries: case report and literature review. Int J Gynecol Pathol 22:189–193PubMedCrossRefPubMedCentralGoogle Scholar
  114. Ohta Y, Suzuki T, Shiokawa A, Mitsuya T, Ota H (2005) Expression of CD10 and cytokeratins in ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 24:239–245PubMedCrossRefPubMedCentralGoogle Scholar
  115. Oliva E, Musulen E, Prat J, Young RH (1993) Transitional cell carcinoma of the renal pelvis with symptomatic ovarian metastases. Int J Surg Pathol 2:231–236CrossRefGoogle Scholar
  116. Oliva E, Egger JF, Young RH (2014) Primary endometrioid stromal sarcoma of the ovary: a clinicopathologic study of 27 cases with morphologic and behavioral features similar to those of uterine low-grade endometrial stromal sarcoma. Am J Surg Pathol 38:305–315PubMedCrossRefPubMedCentralGoogle Scholar
  117. Ordóñez NG (2006) Value of immunohistochemistry in distinguishing peritoneal mesothelioma from serous carcinoma of the ovary and peritoneum. A review and update. Adv Anat Pathol 13:16–25PubMedCrossRefPubMedCentralGoogle Scholar
  118. Parker LP, Duong JL, Wharton JT, Malpica A, Silva EG, Deavers MT (2002) Desmoplastic small round cell tumor: report of a case presenting as a primary ovarian neoplasm. Eur J Gynaec Oncol 23:199–202Google Scholar
  119. Perez Montiel D, Arispe Angulo K, Cantú-de León D, Bornstein Quevedo L, Chanona Vilchis J, Herrera Montalvo L (2015) The value of SATB2 in the differential diagnosis of intestinal-type mucinous tumors of the ovary: primary vs metastatic. Ann Diagn Pathol 19:249–252PubMedCrossRefPubMedCentralGoogle Scholar
  120. Petru E, Pickel H, Heydarfadai M, Lahousen M, Haas J, Schaider H, Tamussino K (1992) Nongenital cancers metastatic to the ovary. Gynecol Oncol 44:83–86PubMedCrossRefPubMedCentralGoogle Scholar
  121. Phillips V, McCluggage WG, Young RH (2006) Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. Int J Gynecol Pathol 26:16–20CrossRefGoogle Scholar
  122. Pins MR, Young RH, Crum CP, Leach IH, Scully RE (1997) Cervical squamous carcinoma in situ with superficial extension to corpus and tubes and invasion of tubes and ovaries. Int J Gynecol Pathol 16:272–278PubMedCrossRefPubMedCentralGoogle Scholar
  123. Pitluk H, Poticha SM (1983) Carcinoma of the colon and rectum in patients less than 40 years of age. Surg Gynecol Obstet 157:335–337PubMedPubMedCentralGoogle Scholar
  124. Pitman MB, Triratanachat S, Young RH, Oliva E (2003) Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma. Int J Gynecol Pathol 23:58–64Google Scholar
  125. Rabban JT, Lerwill MF, McCluggage WG, Grenert JP, Zaloudek CJ (2009) Primary ovarian carcinoid tumors may express CDX-2: a potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol 28:41–48PubMedCrossRefPubMedCentralGoogle Scholar
  126. Ramalingam P, Malpica A, Deavers MT (2012) Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases. Int J Gynecol Pathol 31:490–496PubMedCrossRefPubMedCentralGoogle Scholar
  127. Reid MD, Bastruk O, Shaib WL, Xue Y, Balci S, Choi HJ, Akkas G, Memmis B, Robinson BS, El-Rayes BF, Staley CA, Staley CA, Winer JH, Russell MC, Knight JH, Goodman M, Krasinskas AM, Adsay V (2016) Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. Mod Pathol 29:1243–1253PubMedPubMedCentralCrossRefGoogle Scholar
  128. Reis-Filho JS, Carrilho C, Valenti C et al (2000) Is TTF1 a good immunohistochemical marker to distinguish primary from metastatic lung adenocarcinomas? Pathol Res Pract 196:835–840PubMedCrossRefPubMedCentralGoogle Scholar
  129. Reyes C, Murali R, Park KJ (2015) Secondary involvement of the adnexa and uterine corpus by carcinomas of the uterine cervix: a detailed morphologic description. Int J Gynecol Pathol 34:551–563PubMedPubMedCentralCrossRefGoogle Scholar
  130. Ricardo-Gonzalez RR, Nguyen M, Gokden N, Sangoi AR, Presti JC, McKenney JK (2012) Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread. J Urol 187:852–855PubMedCrossRefPubMedCentralGoogle Scholar
  131. Riopel MA, Ronnett BM, Kurman RJ (1999) Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors. Atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol 23:617–635PubMedCrossRefPubMedCentralGoogle Scholar
  132. Robboy SJ, Scully RE, Norris HJ (1974) Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer (Phila) 33:798–811CrossRefGoogle Scholar
  133. Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME (1995a) Pseudomyxoma peritonei in women. A clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential. Hum Pathol 26:509–524PubMedCrossRefPubMedCentralGoogle Scholar
  134. Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM (1995b) Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to “pseudomyxoma peritonei”. Am J Surg Pathol 19:1390–1408PubMedCrossRefPubMedCentralGoogle Scholar
  135. Ronnett BM, Kurman RJ, Shmookler BM, Sugarbaker PH, Young RH (1997) The morphologic spectrum of ovarian metastases of appendiceal adenocarcinomas. A clinicopathologic and immunohistochemical analysis of tumors often misinterpreted as primary ovarian tumors or metastatic tumors from other gastrointestinal sites. Am J Surg Pathol 2:1144–1155CrossRefGoogle Scholar
  136. Ronnett BM, Yemelyanova AV, Vang R, Gilks CB, Miller D, Gravitt PE, Kurman RJ (2008) Endocervical adenocarcinomas with ovarian metastases. Analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol 32:1835–1853PubMedCrossRefPubMedCentralGoogle Scholar
  137. Saphir O (1951) Signet-ring cell carcinoma. Mil Surg 109:360–369PubMedPubMedCentralGoogle Scholar
  138. Schultheis AM, Ng CK, De Filippo MR, Piscuoglio S, Macedo GS, Gatius S, Perez Mies B, Soslow RA, Lim RS, Viale A, Huberman KH, Palacios JC, Reis-Filho JS, Matias-Guiu, Weigelt B (2016) Massively parallel sequencing-based clonality analysis of synchronous endometrioid endometrial and ovarian carcinomas. J Natl Cancer Inst 108:djv427.
  139. Scully RE, Richardson GS (1961) Luteinization of the stroma of metastatic cancer involving the ovary and its endocrine significance. Cancer (Phila) 14:827–840CrossRefGoogle Scholar
  140. Seidman JD, Kurman RJ, Ronnett BM (2003) Incidence in routine practice with a new approach to improve intraoperative diagnosis. Primary and metastatic mucinous adenocarcinomas in the ovaries. Am J Surg Pathol 27:985–993PubMedCrossRefPubMedCentralGoogle Scholar
  141. Shimada M, Kigawa J, Nishimura R, Yamaguchi S, Kuzuya K, Nakanishi T, Suzuki M, Kita T, Iwasaka T, Terakawa N (2006) Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol 101:234–237PubMedCrossRefPubMedCentralGoogle Scholar
  142. Soslow RA, Rouse RV, Hendrickson MR, Silva EG, Longacre TA (1996) Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. Int J Gynecol Pathol 15:257–265PubMedCrossRefPubMedCentralGoogle Scholar
  143. Spencer JR, Eriksen B, Garnett JE (1993) Metastatic renal tumor presenting as ovarian clear cell carcinoma. Urology 41:582–584PubMedCrossRefPubMedCentralGoogle Scholar
  144. Stewart CJR, Brennan BA, Hammond IG et al (2005) Accuracy of frozen section in distinguishing primary ovarian neoplasia from tumors metastatic to the ovary. Int J Gynecol Pathol 24:356–362PubMedCrossRefPubMedCentralGoogle Scholar
  145. Stewart CJ, Ardakani NM, Doherty DA, Young RH (2014) An evaluation of the morphologic features of low-grade mucinous neoplasms of the appendix metastatic in the ovary, and comparison with primary ovarian mucinous tumors. Int J Gynecol Pathol 33:1–10PubMedCrossRefPubMedCentralGoogle Scholar
  146. Strosberg J, Nasir A, Cragun J, Gardner N, Kvols L (2007) Metastatic carcinoid tumor to the ovary: a clinicopathologic analysis of seventeen cases. Gynecol Oncol 106:65–68PubMedCrossRefPubMedCentralGoogle Scholar
  147. Sty JR, Kun LE, Casper JT (1980) Bone scintigraphy in neuroblastoma with ovarian metastasis. Wis Med J 79:28–29PubMedPubMedCentralGoogle Scholar
  148. Szych C, Staebler A, Connolly DC, Wu R, Cho KR, Ronnett BM (1999) Molecular genetic evidence supporting the clonality and appendiceal origin of pseudomyxoma peritonei in women. Am J Pathol 154:1849–1855PubMedPubMedCentralCrossRefGoogle Scholar
  149. Tabata M, Ichinoe K, Sakuragi N, Shina Y, Yamaguchi T, Mabuchi Y (1987) Incidence of ovarian metastasis in patients with cancer of the uterine cervix. Gynecol Oncol 28:255–261PubMedCrossRefPubMedCentralGoogle Scholar
  150. Tandon RT, Jimenez-Cortez Y, Taub R, Borczuk AC (2018) Immunohistochemistry in peritoneal mesothelioma. A single-center experience of 244 cases. Arch Pathol Lab Med 142:236–242PubMedCrossRefPubMedCentralGoogle Scholar
  151. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O’Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS (2008) Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol 32:1429–1443PubMedCrossRefPubMedCentralGoogle Scholar
  152. Toki N, Tsukamoto N, Kaku T et al (1991) Microscopic ovarian metastasis of the uterine cervical cancer. Gynecol Oncol 41:46–51PubMedCrossRefPubMedCentralGoogle Scholar
  153. Tornos C, Soslow R, Chen S et al (2005) Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol 29:1482–1489PubMedCrossRefPubMedCentralGoogle Scholar
  154. Tso PL, Bringaze WL III, Dauterive AH, Correa P, Cohn I Jr (1987) Gastric carcinoma in the young. Cancer (Phila) 59:1362–1365CrossRefGoogle Scholar
  155. Ulbright TM, Roth LM (1985a) Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol 16:28–34PubMedCrossRefPubMedCentralGoogle Scholar
  156. Ulbright TM, Roth LM (1985b) Secondary tumors of the ovary. In: Roth LM, Czernobilsky B (eds) Tumors and tumor-like conditions of the ovary, Contemporary issues in surgical pathology, vol 6. Churchill-Livingstone, New York, pp 129–152Google Scholar
  157. Ulbright TM, Roth LM, Stehman FB (1984) Secondary ovarian neoplasia. A clinicopathologic study of 35 cases. Cancer (Phila) 53:1164–1174CrossRefGoogle Scholar
  158. Vakiani E, Young RH, Carcangiu ML, Klimstra DS (2008) Acinar cell carcinoma of the pancreas metastatic to the ovary. A report of 4 cases. Am J Surg Pathol 32:1540–1545PubMedCrossRefPubMedCentralGoogle Scholar
  159. Vang R, Gown AM, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM (2006a) Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol 30:1130–1139PubMedCrossRefGoogle Scholar
  160. Vang R, Gown AM, Wu LSF, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM (2006b) Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol 19:1421–1428PubMedCrossRefPubMedCentralGoogle Scholar
  161. Vang R, Gown AM, Zhao C, Barry TS, Isacson C, Richardson MS, Ronnett BM (2007) Ovarian mucinous tumors associated with mature cystic teratomas. Morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. Am J Surg Pathol 31:854–869PubMedCrossRefPubMedCentralGoogle Scholar
  162. Vara A, Madrigal B, Veiga M, Diaz A, Garcia J, Calvo J (1998) Bilateral ovarian metastases from renal clear cell carcinoma. Acta Oncol (Stockh) 37:379–380CrossRefGoogle Scholar
  163. Veras E, Srodon M, Neijstrom ES, Ronnett BM (2009) Metastatic HPV-related cervical adenocarcinomas presenting with thromboembolic events (trousseau syndrome): clinicopathologic characteristics of two cases. Int J Gynecol Pathol 28:134–139PubMedCrossRefPubMedCentralGoogle Scholar
  164. Wick MR, Lillemoe TJ, Copland GT, Swanson PE, Manivel JC, Kiang DT (1989) Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum Pathol 20:281–287PubMedCrossRefPubMedCentralGoogle Scholar
  165. Yakushiji M, Tazaki T, Nishimura H, Kato T (1987) Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases. Acta Obstet Gynaecol Jpn 39:479–485Google Scholar
  166. Yang C, Sun L, Zhang L, Zhou L, Zhao M, Peng Y, Niu D, Li Z, Huang X, Kang Q, Jia L, Lai J, Cao D (2018) Diagnostic utility of SATB2 in metastatic Krukenberg tumors of the ovary. An immunohistochemical study of 70 cases with comparison to CDX2, CK7, CK20, chromogranin, and synaptophysin. Am J Surg Pathol 42:160–171PubMedCrossRefPubMedCentralGoogle Scholar
  167. Yemelyanova AV, Vang R, Judson K, Wu LSF, Ronnett BM (2008) Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol 32:128–138PubMedCrossRefPubMedCentralGoogle Scholar
  168. Young RH (1995) Urachal adenocarcinoma metastatic to the ovary simulating primary mucinous cystadenocarcinoma of the ovary: report of a case. Virchows Arch 426:529–532PubMedCrossRefPubMedCentralGoogle Scholar
  169. Young RH (2004) Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. Semin Diagn Pathol 21:134–150PubMedCrossRefPubMedCentralGoogle Scholar
  170. Young RH (2006) From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part I. Historical perspective, general principles, mucinous tumors including the Krukenberg tumor. Adv Anat Pathol 13:205–227PubMedCrossRefPubMedCentralGoogle Scholar
  171. Young RH (2007) From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol 14:149–177PubMedCrossRefPubMedCentralGoogle Scholar
  172. Young RH, Hart WR (1989) Metastases from carcinomas of the pancreas simulating primary mucinous tumors of the ovary: a report of seven cases. Am J Surg Pathol 13:748–756PubMedCrossRefPubMedCentralGoogle Scholar
  173. Young RH, Hart WR (1992) Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. Int J Gynecol Pathol 11:96–104PubMedCrossRefPubMedCentralGoogle Scholar
  174. Young RH, Hart WR (1998) Metastatic intestinal carcinomas simulating primary ovarian clear cell carcinoma and secretory endometrioid carcinoma. A clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 22:805–815PubMedCrossRefPubMedCentralGoogle Scholar
  175. Young RH, Scully RE (1985) Ovarian metastases from cancer of the lung: problems in interpretation – a report of seven cases. Gynecol Oncol 21:337–350PubMedCrossRefPubMedCentralGoogle Scholar
  176. Young RH, Scully RE (1988a) Urothelial and ovarian carcinomas of identical cell types: problems in interpretation. A report of three cases and review of the literature. Int J Gynecol Pathol 7:197–211PubMedCrossRefPubMedCentralGoogle Scholar
  177. Young RH, Scully RE (1988b) Mucinous tumors of the ovary associated with mucinous adenocarcinomas of the cervix. A clinicopathological analysis of 16 cases. Int J Gynecol Pathol 7:99–111PubMedCrossRefPubMedCentralGoogle Scholar
  178. Young RH, Scully RE (1989) Alveolar rhabdomyosarcoma metastatic to the ovary. A report of two cases and discussion of the differential diagnosis of small cell malignant tumors of the ovary Cancer (Phila) 64:899–904Google Scholar
  179. Young RH, Scully RE (1990a) Ovarian metastases from carcinoma of the gallbladder and extrahepatic bile ducts simulating primary tumors of the ovary: a report of six cases. Int J Gynecol Pathol 9:60–72PubMedCrossRefPubMedCentralGoogle Scholar
  180. Young RH, Scully RE (1990b) Sarcomas metastatic to the ovary. A report of 21 cases. Int J Gynecol Pathol 9:231–252PubMedCrossRefPubMedCentralGoogle Scholar
  181. Young RH, Scully RE (1991a) Metastatic tumors in the ovary: a problem-oriented approach and review of the recent literature. Semin Diagn Pathol 8:250–276PubMedPubMedCentralGoogle Scholar
  182. Young RH, Scully RE (1991b) Malignant melanoma metastatic to the ovary: a clinicopathologic analysis of 20 cases. Am J Surg Pathol 15:849–860PubMedCrossRefPubMedCentralGoogle Scholar
  183. Young RH, Scully RE (2001) Differential diagnosis of ovarian tumors based primarily on their patterns and cell types. Semin Diagn Pathol 18:161–235PubMedPubMedCentralGoogle Scholar
  184. Young RH, Carey RW, Robboy SJ (1981) Breast carcinoma masquerading as a primary ovarian neoplasm. Cancer (Phila) 48:210–212CrossRefGoogle Scholar
  185. Young RH, Prat J, Scully RE (1984) Endometrial stromal sarcomas of the ovary. A clinicopathologic analysis of 23 cases. Cancer (Phila) 53:1143–1155CrossRefGoogle Scholar
  186. Young RH, Gilks CB, Scully RE (1991) Mucinous tumors of the appendix associated with mucinous tumors of the ovary and pseudomyxoma peritonei: a clinicopathological analysis of 22 cases supporting an origin in the appendix. Am J Surg Pathol 15:415–429PubMedCrossRefPubMedCentralGoogle Scholar
  187. Young RH, Gersell DJ, Clement PB, Scully RE (1992a) Hepatocellular carcinoma metastatic to the ovary: a report of three cases discovered during life with discussion of the differential diagnosis of hepatoid tumors of the ovary. Hum Pathol 23:574–580PubMedCrossRefPubMedCentralGoogle Scholar
  188. Young RH, Eichhorn JH, Dickersin GR, Scully RE (1992b) Ovarian involvement by the intra-abdominal desmoplastic small round cell tumor with divergent differentiation. A report of three cases. Hum Pathol 23:454–464PubMedCrossRefPubMedCentralGoogle Scholar
  189. Young RH, Kozakewich HPW, Scully RE (1993a) Metastatic ovarian tumors in children: a report of 14 cases and review of the literature. Int J Gynecol Pathol 12:8–19PubMedCrossRefPubMedCentralGoogle Scholar
  190. Young RH, Gersell DJ, Roth LM, Scully RE (1993b) Ovarian metastases from cervical carcinomas other than pure adenocarcinomas: a report of 12 cases. Cancer (Phila) 71:407–418CrossRefGoogle Scholar
  191. Young RH, Jackson A, Wells M (1994) Ovarian metastasis from thyroid carcinoma twelve years after partial thyroidectomy mimicking struma ovarii. Report of a case. Int J Gynecol Pathol 13:181–185PubMedCrossRefPubMedCentralGoogle Scholar
  192. Yu TJ, Iwasaki I, Horie H, Tamaru J, Takahashi A (1986) Endolymphatic stromal myosis of the uterus with metastasis to ovary and recurrence in vagina. Acta Pathol Jpn 36:301–308PubMedPubMedCentralGoogle Scholar
  193. Zaino RJ, Unger ER, Whitney C (1984) Synchronous carcinomas of the uterine corpus and ovary. Gynecol Oncol 19:329–335PubMedCrossRefPubMedCentralGoogle Scholar
  194. Zaloudek C, Miller TR, Stern JL (1995) Desmoplastic small cell tumor of the ovary: a unique polyphenotypic tumor with an unfavorable prognosis. Int J Gynecol Oncol 14:260–265Google Scholar
  195. Zamecnik M, Voltr L, Stuk J, Chlumska A (2008) Krukenberg tumor with yolk sac tumor differentiation. Int J Gynecol Pathol 27:223–228PubMedPubMedCentralGoogle Scholar
  196. Zhang PJ, Gao HG, Pasha TL, Litzky L, LiVolsi V (2009) TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol 28:10–18PubMedCrossRefPubMedCentralGoogle Scholar
  197. Zukerberg LR, Young RH (1990) Chordoma metastatic to the ovary: report of a case. Arch Path Lab Med 114:208–210PubMedPubMedCentralGoogle Scholar

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Authors and Affiliations

  1. 1.Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA

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