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Metastatic Tumors of the Ovary

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Book cover Blaustein's Pathology of the Female Genital Tract

Abstract

While commonest as an autopsy finding, tumors that spread to the ovary are not rare in surgical pathology specimens and their misinterpretation may have significant adverse consequences for the patient. They may spread from adjacent sites by direct local extension or from distant extragenital sites. The latter tumors are truly metastatic, whereas the designation “metastatic” is sometimes not used for those that are secondary from local sites. For simplicity this discussion includes spread to the ovary from all sites.

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References

  • Abdul-Hafeez M, Akhtar M, Aqeel HSB, Kidess EA (1987) Placental site trophoblastic tumor: report of a case with review of literature. Ann Saudi Med 7:340–344

    Article  Google Scholar 

  • Acosta-Sison H (1958) The relative frequency of various anatomic sites as the point of first metastasis in 32 cases of chorionepithelioma. Am J Obstet Gynecol 75:1149–1152

    Article  PubMed  CAS  Google Scholar 

  • Agoff SN, Lamps LW, Philip AT, Amin MB, Schmidt RA, True LD, Folpe AL (2000) Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 13:238–242

    Article  PubMed  CAS  Google Scholar 

  • Alvarado-Cabrero I, Rodríguez-Gómez A, Castelan-Pedraza J, Valencia-Cedillo R (2013) Metastatic ovarian tumors. A clinicopathologic study of 140 cases. Anal Quant Cytopathol Histopathol 35:241–248

    Google Scholar 

  • Amorn Y, Knight WA (1978) Primary linitis plastica of the colon: report of two cases and review of the literature. Cancer (Phila) 41:2420–2425

    Article  CAS  Google Scholar 

  • Anglesio MS, Wang YK, Maassen M, Horlings HM, Bashashati A, Senz J, Mackenzie R, Grewal DS, Li-Chang H, Karnezis AN, Sheffield BS, McConechy MK, Kommoss F, Taran FA, Staebler A, Shah SP, Wallwiener D, Brucker S, Gilks CB, Kommoss S, Huntsman DG (2016) Synchronous endometrial and ovarian carcinomas: evidence of clonality. J Natl Cancer Inst 108:djv428. https://doi.org/10.1093/jnci/djv428

  • Baker PM, Oliva E (2004) Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol 24:39–55

    Google Scholar 

  • Baker PM, Clement PB, Young RH (2005) Malignant peritoneal mesothelioma in women. A study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. Am J Clin Pathol 123:724–737

    Article  PubMed  Google Scholar 

  • Beck RP, Latour JPA (1963) Necropsy reports on 36 cases of endometrial carcinoma. Am J Obstet Gynecol 85:307–311

    Article  PubMed  CAS  Google Scholar 

  • Bennett JA, Young RH, Chuang AY, Lerwill MF (2017) Ovarian metastases of breast cancers with signet ring cells: a report of 17 cases including 14 Krukenberg tumors. Int J Gynecol Pathol (in press). https://doi.org/10.1097/PGP.0000000000000462

  • Berg KB, Schaeffer DF (2017) SATB2 as an immunohistochemical marker for colorectal adenocarcinoma. A concise review of benefits and pitfalls. Arch Pathol Lab Med 141:1428–1433

    Article  PubMed  Google Scholar 

  • Birnkrant A, Sampson J, Sugarbaker PH (1986) Ovarian metastasis from colorectal cancer. Dis Colon Rectum 29:767–771

    Article  PubMed  CAS  Google Scholar 

  • Bombonati A, Lerwill MF (2012) Metastases to and from the breast. Surg Pathol Clin 5:179–747

    Article  Google Scholar 

  • Brogioni S, Viacava P, Tomisti L, Martino E, Macchia E (2007) A special case of bilateral metastases in a woman with papillary carcinoma of the thyroid. Exp Clin Endocrinol Diabetes 115:397–400

    Article  PubMed  CAS  Google Scholar 

  • Brown BL, Scharifker DA, Gordon R, Deppe GG, Cohen CJ (1980) Bronchial carcinoid tumor with ovarian metastasis. A light microscopic and ultrastructural study. Cancer 46:543–546

    Article  PubMed  CAS  Google Scholar 

  • Bullon A, Arseneau J, Prat J, Young RH, Scully RE (1981) Tubular Krukenberg tumor. A problem in histopathologic diagnosis. Am J Surg Pathol 5:225–232

    Article  PubMed  Google Scholar 

  • Bunker ML (1959) The terminal findings in endometrial carcinoma. Am J Obstet Gynecol 77:530–538

    Article  PubMed  CAS  Google Scholar 

  • Byrne DJ, Deb S, Takano EA, Fox SB (2017) GATA3 expression in triple-negative breast cancers. Histopathol 71:63–71

    Article  Google Scholar 

  • Cameron RI, Ashe P, O’Rourke DM, Foster H, McCluggage WG (2003) A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 22:272–276

    Article  PubMed  CAS  Google Scholar 

  • Cao D, Ji H, Ronnett BM (2004) Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas of the ovary. Int J Gynecol Pathol 24:67–72

    CAS  Google Scholar 

  • Carlson JW, Nucci MR, Brodsky J, Crum CP, Hirsch MS (2007) Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. Histopathology 51:305–312

    Article  PubMed  CAS  Google Scholar 

  • Caron P, Roche H, Gorguet B, Martel P, Bennet A, Carton M (1990) Mammary ovarian metastases with stromal cell hyperplasia and postmenopausal virilization. Cancer (Phila) 66:1221–1224

    Article  CAS  Google Scholar 

  • Chapel DB, Husain AN, Krausz T, McGregor SM (2017) PAX8 expression in a subset of malignant peritoneal mesotheliomas and benign mesothelium has diagnostic implications in the differential diagnosis of ovarian serous carcinoma. Am J Surg Pathol 41:1675–1682

    Article  PubMed  Google Scholar 

  • Che M, Tornos C, Deavers MT (2001) Ovarian mixed-epithelial carcinomas with a microcystic pattern and signet-ring cells. Int J Gynecol Pathol 20:323–328

    Article  PubMed  CAS  Google Scholar 

  • Chen ZME, Wang HL (2004) Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. Am J Surg Pathol 28:1352–1359

    Article  PubMed  Google Scholar 

  • Clement PB, Young RH, Scully RE (1996) Malignant mesotheliomas presenting as ovarian masses. A report of nine cases, including two primary ovarian mesotheliomas. Am J Surg Pathol 20:1067–1080

    Article  PubMed  CAS  Google Scholar 

  • Creasman WT, Lukeman J (1972) Role of the fallopian tube in dissemination of malignant cells in corpus cancer. Cancer (Phila) 20:456–457

    Article  Google Scholar 

  • DeCostanzo DC, Elias JM, Chumas JC (1997) Necrosis in 84 ovarian carcinomas: a morphologic study of primary versus metastatic colonic cancer with a selective immunohistochemical analysis of cytokeratin subtypes and carcinoembryonic antigen. Int J Gynecol Pathol 16:245–249

    Article  PubMed  CAS  Google Scholar 

  • Desouki MM, Lioyd J, Xu H, Cao D, Barner R, Zhao C (2013) CDX2 may be a useful marker to distinguish primary ovarian carcinoid from gastrointestinal metastatic carcinoids to the ovary. Hum Pathol 44:2536–2541

    Article  PubMed  CAS  Google Scholar 

  • DiLoreto C, Di Lauro V, Puglisi F et al (1997) Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol 50:30–32

    Article  CAS  Google Scholar 

  • Eichhorn JH, Young RH, Scully RE (1993) Non-pulmonary small cell carcinomas of extragenital origin metastatic to the ovary: a report of seven cases. Cancer (Phila) 71:177–186

    Article  CAS  Google Scholar 

  • Eifel P, Hendrickson M, Ross J, Ballon S, Martinez A, Kempson R (1982) Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer (Phila) 50:163–170

    Article  CAS  Google Scholar 

  • Elhajj M, Mazurka J, Daya D (2002) Desmoplastic small round cell tumor presenting in the ovaries: report of a case and review of the literature. Int J Gynecol Cancer 12:760–763

    Article  PubMed  CAS  Google Scholar 

  • Elishaev E, Gilks CB, Miller D, Srodon M, Kurman RJ, Ronnett BM (2005) Synchronous and metachronous endocervical and ovarian neoplasms. Evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. Am J Surg Pathol 29:281–294

    Article  PubMed  Google Scholar 

  • Fitzgibbons PL, Martin SE, Simmons TJ (1987) Malignant melanoma metastatic to the ovary. Am J Surg Pathol 11:959–964

    Article  PubMed  CAS  Google Scholar 

  • Gagnon Y, Tetu B (1989) Ovarian metastases of breast carcinoma. A clinicopathologic study of 59 cases. Cancer (Phila) 64:892–898

    Article  CAS  Google Scholar 

  • Gilks CB, Kommoss F (2018) Synchronous tumors of the female reproductive tract. Pathol 50:214–221

    Article  Google Scholar 

  • Gill AJ, Chou A, Vilain R, Clarkson A, Lui M, Jin R, Tobias V, Samra J, Goldstein D, Smith C, Sioson L, Parker N, Smith RC, Sywak M, Sidhu SB, Wyatt JM, Robinson BG, Eckstein RP, Benn DE, Clifton-Bligh RJ (2010) Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types. Am J Surg Pathol 34:636–644

    PubMed  Google Scholar 

  • Giordano G, Cruz Viruel N, Silini EM, Nogales FF (2017) Adenocarcinoma of the lung metastatic to the ovary with a signet ring cell component. Int J Surg Pathol 25:365–367

    Article  PubMed  Google Scholar 

  • Gokden N, Gokden M, Phan DC, McKenney JK (2008) The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics. An immunohistochemical study with comparison to renal cell carcinoma marker. Am J Surg Pathol 32:1462–1467

    Article  PubMed  Google Scholar 

  • Goldblum J, Hart WR (1995) Localized and diffuse mesotheliomas of the genital tract and peritoneum in women. A clinicopathological study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas and localized fibrous tumors. Am J Surg Pathol 19:1124–1137

    Article  PubMed  CAS  Google Scholar 

  • Graffner HOL, Alm POA, Oscarson JEA (1983) Prophylactic oophorectomy in colorectal carcinoma. Am J Surg 146:233–235

    Article  PubMed  CAS  Google Scholar 

  • Green LK, Silva EG (1989) Hepatoblastoma in an adult with metastasis to the ovaries. Am J Clin Pathol 92:110–115

    Article  PubMed  CAS  Google Scholar 

  • Gupta D, Deavers MT, Silva EG et al (2004) Malignant melanoma involving the ovary. A clinicopathologic and immunohistochemical study of 23 cases. Am J Surg Pathol 28:771–780

    Article  PubMed  Google Scholar 

  • Hagemann IS, Pfeifer JD, Cao D (2013) Mammaglobin expression in gynecologic adenocarcinomas. Hum Pathol 44:628–635

    Article  PubMed  CAS  Google Scholar 

  • Hale RW (1968) Krukenberg tumor of the ovaries. A review of 81 records. Obstet Gynecol 32:221–225

    PubMed  CAS  Google Scholar 

  • Harris M, Howell A, Chrissohou M, Swindell RIC, Hudson M, Sellwood RA (1984) A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer 50:23–30

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hayashi Y, Kikuchi F, Oka T et al (1988) Rhabdomyosarcoma with bone marrow metastasis simulating acute leukemia. Report of two cases. Acta Pathol Jpn 38:789–798

    PubMed  CAS  Google Scholar 

  • Hecht JL, Pinkus JL, Weinstein LJ et al (2001) The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin. Am J Clin Pathol 116:483–488

    Article  PubMed  CAS  Google Scholar 

  • Holtz F, Hart WR (1982) Krukenberg tumors of the ovary. A clinicopathologic analysis of 27 cases. Cancer (Phila) 50:2438–2447

    Article  CAS  Google Scholar 

  • Hopping RA, Dockerty MB, Masson JC (1942) Carcinoid tumor of the appendix. Report of a case in which extensive intra-abdominal metastases occurred, including involvement of the right ovary. Arch Surg 45:613–622

    Article  Google Scholar 

  • Hristov AC, Young RH, Vang R, Yemelyanova AV, Seidman JD, Ronnett BM (2007) Ovarian metastases of appendiceal tumors with goblet cell carcinoid-like and signet ring cell patterns: a report of 30 cases. Am J Surg Pathol 31:1502–1511

    Article  PubMed  Google Scholar 

  • Hsiu J-G, Kemp GM, Singer GA, Rawls WH, Siddiky MA (1991) Transitional cell carcinoma of the renal pelvis with ovarian metastasis. Gynecol Oncol 41:178–181

    Article  PubMed  CAS  Google Scholar 

  • Insabato L, DeRosa G, Franco R et al (2003) Ovarian metastasis from renal cell carcinoma: a report of three cases. Int J Surg Pathol 11:309–312

    Article  PubMed  Google Scholar 

  • Irving JA, Young RH (2005) Lung carcinoma metastatic of the ovary. A clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis. Am J Surg Pathol 29:997–1006

    PubMed  Google Scholar 

  • Irving JA, Lerwill MF, Young RH (2005) Gastrointestinal stromal tumors metastatic to the ovary. A report of five cases. Am J Surg Pathol 29:920–926

    Article  PubMed  Google Scholar 

  • Irving JA, Vasques DR, McGuinness TB, Young RH (2006) Krukenberg tumor of renal pelvic origin: report of a case with selected comments on ovarian tumors metastatic from the urinary tract. Int J Gynecol Pathol 25:147–150

    Article  PubMed  Google Scholar 

  • Ji H, Isacson C, Seidman JD, Kurman RJ, Ronnett BM (2002) Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas. Int J Gynecol Pathol 21:391–400

    Article  PubMed  Google Scholar 

  • Judson K, McCormick C, Vang R, Yemelyanova AV, Wu LSF, Bristow RE, Ronnett BM (2008) Women with undiagnosed colorectal adenocarcinomas presenting with ovarian metastases: Clinicopathologic features and comparison with women having known colorectal adenocarcinomas and ovarian involvement. Int J Gynecol Pathol 27:182–190

    PubMed  Google Scholar 

  • Kaminski PF, Norris HJ (1984) Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol 64:553–556

    PubMed  CAS  Google Scholar 

  • Kandalaft PL, Gown AM, Isacson C (2014) The lung-restricted marker napsin a is highly expressed in clear cell carcinomas of the ovary. Am J Clin Pathol 142:830–836

    Article  PubMed  Google Scholar 

  • Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, Soslow RA, Park KJ (2015) Gastric-type endocervical adenocarcinoma: an aggressive tumor with unusual metastatic patterns and poor prognosis. Am J Surg Pathol 39:1449–1457

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaufmann O, Dietel M (2000) Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins a and B. Histopathology 36:8–16

    Article  PubMed  CAS  Google Scholar 

  • Kershisnik MM, Ro JY, Cannon GH, Ordóñez NG, Ayala AG, Silva EG (1995) Histiocytic reaction in pelvic peritoneum associated with oxidized regenerated cellulose. Am J Clin Pathol 103:27–31

    Article  PubMed  CAS  Google Scholar 

  • Khunamornpong S, Siriaunkgul S, Chunduan A (1999) Metastatic hepatocellular carcinoma of the ovary. Int J Gynecol Obstet 64:189–191

    Article  CAS  Google Scholar 

  • Khunamornpong S, Suprasert PS, Pojchamarnwiputh S, Chiangmai WN, Settakorn J, Siriaunkgul S (2006a) Primary and metastatic mucinous adenocarcinomas of the ovary: evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol 101:152–157

    Article  PubMed  Google Scholar 

  • Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH (2007) Intrahepatic cholangiocarcinoma metastatic to the ovary: a report of 16 cases of an underemphasized form of secondary tumor of the ovary that may mimic primary neoplasia. Am J Surg Pathol 31:1788–1799

    Article  PubMed  Google Scholar 

  • Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH (2008) Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol 27:366–379

    Article  PubMed  Google Scholar 

  • Kim K-R, Scully RE (1990) Peritoneal keratin granulomas with carcinomas of endometrium and ovary and atypical polypoid adenomyoma of endometrium. A clinicopathological analysis of 22 cases. Am J Surg Pathol 14:925–932

    Article  PubMed  CAS  Google Scholar 

  • Kim KR, Lee HI, Lee SK, Ro JY, Robboy SJ (2007) Is stromal microinvasion in primary mucinous ovarian tumors with “mucin granuloma” true invasion? Am J Surg Pathol 31:546–554

    Article  PubMed  Google Scholar 

  • Kim CJ, Baruch-Oren T, Lin F, Fan XS, Yang XJ, Wang HL (2016) Value of SATB2 immunostaining in the distinction between small intestinal and colorectal adenocarcinomas. J Clin Pathol 69:1046–1050

    Article  PubMed  CAS  Google Scholar 

  • Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, Berkowitz RS, Muto MG, Crum CP (2007) Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 31:161–169

    Article  PubMed  Google Scholar 

  • Kiyokawa T, Young RH, Scully RE (2006) Krukenberg tumors of the ovary. A clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol 31:277–299

    Article  Google Scholar 

  • Kubba LA, McCluggage WG, Liu J, Malpica A, Euscher ED, Silva EG, Deavers MT (2008) Thyroid transcription factor-1 expression in ovarian epithelial neoplasms. Mod Pathol 21:485–490

    Article  PubMed  CAS  Google Scholar 

  • Kuo T-T, Hsueh S (1984) Mucicarminophilic histiocytosis. A polyvinylpyrrolidone (PVP) storage disease simulating signet-ring cell carcinoma. Am J Surg Pathol 8:419–428

    Article  PubMed  CAS  Google Scholar 

  • Kurek R, Von Knoblock R, Feek U, Heidenreich A, Hofmann R (2001) Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis. J Urol 166:985

    Article  PubMed  CAS  Google Scholar 

  • Lash RH, Hart WR (1987) Intestinal adenocarcinomas metastatic to the ovaries. A clinicopathological evaluation of 22 cases. Am J Surg Pathol 11:114–121

    Article  PubMed  CAS  Google Scholar 

  • Laury AR, Peret R, Piao H, Krane JF, Barletta JA, French C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin R, Hirsch MS (2011) A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol 35:816–826

    Article  PubMed  Google Scholar 

  • Lee KR, Young RH (2003) The distinction between primary and metastatic mucinous carcinomas of the ovary. Am J Surg Pathol 2:281–292

    Article  Google Scholar 

  • Lee MJ, Lee HS, Kim WH, Choi Y, Yang M (2003) Expressions of mucins and cytokeratins in primary carcinomas of the digestive system. Mod Pathol 16:403–410

    Article  PubMed  Google Scholar 

  • Lee AH, Paish EC, Marchio C, Sapino A, Schmitt FC, Ellis IO, Reis-Filho JS (2007) The expression of Wilms’ tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology 51:824–828

    Article  PubMed  CAS  Google Scholar 

  • Lee S-J, Bae J-H, Lee A-W, Tong S-Y, Park Y-G, Park J-S (2009) Clinical characteristics of metastatic tumors to the ovaries. J Korean Med Sci 24:114–119

    Article  PubMed  PubMed Central  Google Scholar 

  • Leroy X, Farine MO, Buob D, Wacrenier A, Copin MC (2007) Diagnostic value of cytokeratin 7, CD10 and mesothelin in distinguishing ovarian clear cell carcinoma from metastasis of renal clear cell carcinoma. Histopathology 51:846–876

    Article  Google Scholar 

  • Lerwill MF, Young RH (2006) Ovarian metastases of intestinal-type gastric carcinoma. A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor. Am J Surg Pathol 31:1382–1388

    Article  Google Scholar 

  • Lewis MR, Deavers MT, Silva EG, Malpica A (2006) Ovarian involvement by metastatic colorectal adenocarcinoma. Still a diagnostic challenge. Am J Surg Pathol 30:177–184

    Article  PubMed  Google Scholar 

  • Liang L, Huang H, Dadhania V, Zhang J, Zhang M, Liu J (2016) Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases. Hum Pathol 51:96–102

    Article  PubMed  PubMed Central  Google Scholar 

  • Logani S, Baloch ZW, Snyder PJ, Weinstein R, LiVolvi VA (2001) Cystic ovarian metastasis from papillary thyroid carcinoma: a case report. Thyroid 11:1073–1075

    Article  PubMed  CAS  Google Scholar 

  • Logani S, Oliva E, Amin MB, Folpe AL, Cohen C, Young RH (2003) Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers. Histogenic and diagnostic implications. Am J Surg Pathol 27:1434–1441

    Article  PubMed  Google Scholar 

  • Logani S, Oliva E, Arnell PM, Amin MB, Young RH (2005) Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. Mod Pathol 18:19–25

    Article  PubMed  CAS  Google Scholar 

  • Longacre TA, O’Hanlan K, Hendrickson MR (1996) Adenoid cystic carcinoma of the submandibular gland with symptomatic ovarian metastases. Int J Gynecol Pathol 15:349–355

    Article  PubMed  CAS  Google Scholar 

  • MacKeigan JM, Ferguson JA (1979) Prophylactic oophorectomy and colorectal cancer in premenopausal patients. Dis Colon Rectum 22:401–405

    Article  PubMed  CAS  Google Scholar 

  • Martin-Hernández R, Mollejo Villanueva M, Navarro Sánchez M, Carabias López E (2015) Ovarian metastasis of a thymoma: report of a case and literature review. Int J Gynecol Pathol 34:374–378

    PubMed  Google Scholar 

  • McCluggage WG (2008) Immunohistochemical markers as a diagnostic aid in ovarian pathology. Diagn Histopathol 14:335–351

    Article  Google Scholar 

  • McCluggage WG (2012) Immunohistochemistry in the distinction between primary and metastatic ovarian mucinous neoplasms. J Clin Pathol 65:596–600

    Article  PubMed  Google Scholar 

  • McCluggage WG, Wilkinson N (2005) Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features. Histopathology 47:231–247

    Article  PubMed  CAS  Google Scholar 

  • McCluggage WG, Young RH (2005) Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol 22:3–32

    Article  PubMed  Google Scholar 

  • McCluggage WG, Young RH (2008) Primary ovarian mucinous tumors with signet ring cells: report of three cases with discussion of so-called primary Krukenberg tumor. Am J Surg Pathol 32:1373–1379

    Article  PubMed  Google Scholar 

  • McCluggage WG, Bissonnette JP, Young RH (2006) Primary malignant melanoma of the ovary: a report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 25:321–329

    Article  PubMed  Google Scholar 

  • McKenney JK, Soslow RA, Longacre TA (2008) Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol 32:645–655

    Article  PubMed  Google Scholar 

  • Meriden Z, Yemelyanova AV, Vang R, Ronnett BM (2011) Ovarian metastases of pancreaticobiliary tract adenocarcinomas: analysis of 35 cases, with emphasis on the ability of metastases to simulate primary ovarian mucinous tumors. Am J Surg Pathol 35:276–288

    Article  PubMed  Google Scholar 

  • Merino MJ, Edmonds P, LiVolsi V (1985) Appendiceal carcinoma metastatic to the ovaries and mimicking primary ovarian tumors. Int J Gynecol Pathol 4:110–120

    Article  PubMed  CAS  Google Scholar 

  • Mete O, Yeğen G, Güllüoğlu MG, Kapran Y, Klöppel G (2011) An unusual clinical presentation of pancreatic solid pseudopapillary tumor with ovarian metastases: a diagnostic dilemma. Int J Surg Pathol 19:342–345

    Article  PubMed  Google Scholar 

  • Meyer WH, Yu GW, Milvenan ES, Jeffs RD, Kaizer H, Leventhal BG (1979) Ovarian involvement in neuroblastoma. Med Pediatr Oncol 7:49–54

    Article  PubMed  CAS  Google Scholar 

  • Miettinen M, Wang ZF, Lasota J (2009) DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol 33:1401–1408

    Article  PubMed  Google Scholar 

  • Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfot R, Waloszczyk P, Biernat W, Lasota J, Wang Z (2014) GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol 38:13–22

    Article  PubMed  PubMed Central  Google Scholar 

  • Milingos D, Doumplis D, Savage P, Seckl M, Lindsay I, Smith JR (2007) Placental site trophoblastic tumor with an ovarian metastasis. Int J Gynecol Cancer 17:925–927

    Article  PubMed  CAS  Google Scholar 

  • Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH (2003) Appendiceal mucinous neoplasms. A clinicopathologic analysis of 107 cases. Am J Surg Pathol 27:1089–1103

    Article  PubMed  Google Scholar 

  • Mitsushita J, Netsu S, Suzuki K, Nokubi M, Tanaka A (2017) Metastatic ovarian tumors originating from a small bowel adenocarcinoma - a case report and brief literature review. Int J Gynecol Pathol 36:253–260

    Article  PubMed  Google Scholar 

  • Moh M, Krings G, Ates D, Aysal A, Kim GE, Rabban JT (2016) SATB2 expression distinguishes ovarian metastases of colorectal and appendiceal origin from primary ovarian tumors of mucinous or endometrioid type. Am J Surg Pathol 40:419–432

    Article  PubMed  Google Scholar 

  • Monteagudo C, Merino MJ, Laporte N, Neumann RD (1991) Value of gross cystic disease fluid protein-15 in distinguishing metastatic breast carcinomas among poorly differentiated neoplasms involving the ovary. Hum Pathol 22:368–372

    Article  PubMed  CAS  Google Scholar 

  • Nonaka D, Chiriboga L, Soslow RA (2008) Expression of Pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol 32:1566–1571

    Article  PubMed  Google Scholar 

  • Oberg KC, Wells K, Seraj IM et al (2002) ACTH-secreting islet cell tumor of the pancreas presenting as bilateral ovarian tumors and Cushing’s syndrome. Int J Gynecol Pathol 21:276–280

    Article  PubMed  Google Scholar 

  • Ohira S, Shiohara S, Itoh K et al (2003) Urachal adenocarcinoma metastatic to the ovaries: case report and literature review. Int J Gynecol Pathol 22:189–193

    Article  PubMed  Google Scholar 

  • Ohta Y, Suzuki T, Shiokawa A, Mitsuya T, Ota H (2005) Expression of CD10 and cytokeratins in ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 24:239–245

    Article  PubMed  Google Scholar 

  • Oliva E, Musulen E, Prat J, Young RH (1993) Transitional cell carcinoma of the renal pelvis with symptomatic ovarian metastases. Int J Surg Pathol 2:231–236

    Article  Google Scholar 

  • Oliva E, Egger JF, Young RH (2014) Primary endometrioid stromal sarcoma of the ovary: a clinicopathologic study of 27 cases with morphologic and behavioral features similar to those of uterine low-grade endometrial stromal sarcoma. Am J Surg Pathol 38:305–315

    Article  PubMed  Google Scholar 

  • Ordóñez NG (2006) Value of immunohistochemistry in distinguishing peritoneal mesothelioma from serous carcinoma of the ovary and peritoneum. A review and update. Adv Anat Pathol 13:16–25

    Article  PubMed  Google Scholar 

  • Parker LP, Duong JL, Wharton JT, Malpica A, Silva EG, Deavers MT (2002) Desmoplastic small round cell tumor: report of a case presenting as a primary ovarian neoplasm. Eur J Gynaec Oncol 23:199–202

    CAS  Google Scholar 

  • Perez Montiel D, Arispe Angulo K, Cantú-de León D, Bornstein Quevedo L, Chanona Vilchis J, Herrera Montalvo L (2015) The value of SATB2 in the differential diagnosis of intestinal-type mucinous tumors of the ovary: primary vs metastatic. Ann Diagn Pathol 19:249–252

    Article  PubMed  Google Scholar 

  • Petru E, Pickel H, Heydarfadai M, Lahousen M, Haas J, Schaider H, Tamussino K (1992) Nongenital cancers metastatic to the ovary. Gynecol Oncol 44:83–86

    Article  PubMed  CAS  Google Scholar 

  • Phillips V, McCluggage WG, Young RH (2006) Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. Int J Gynecol Pathol 26:16–20

    Article  Google Scholar 

  • Pins MR, Young RH, Crum CP, Leach IH, Scully RE (1997) Cervical squamous carcinoma in situ with superficial extension to corpus and tubes and invasion of tubes and ovaries. Int J Gynecol Pathol 16:272–278

    Article  PubMed  CAS  Google Scholar 

  • Pitluk H, Poticha SM (1983) Carcinoma of the colon and rectum in patients less than 40 years of age. Surg Gynecol Obstet 157:335–337

    PubMed  CAS  Google Scholar 

  • Pitman MB, Triratanachat S, Young RH, Oliva E (2003) Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma. Int J Gynecol Pathol 23:58–64

    Google Scholar 

  • Rabban JT, Lerwill MF, McCluggage WG, Grenert JP, Zaloudek CJ (2009) Primary ovarian carcinoid tumors may express CDX-2: a potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol 28:41–48

    Article  PubMed  Google Scholar 

  • Ramalingam P, Malpica A, Deavers MT (2012) Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases. Int J Gynecol Pathol 31:490–496

    Article  PubMed  Google Scholar 

  • Reid MD, Bastruk O, Shaib WL, Xue Y, Balci S, Choi HJ, Akkas G, Memmis B, Robinson BS, El-Rayes BF, Staley CA, Staley CA, Winer JH, Russell MC, Knight JH, Goodman M, Krasinskas AM, Adsay V (2016) Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. Mod Pathol 29:1243–1253

    Article  PubMed  PubMed Central  Google Scholar 

  • Reis-Filho JS, Carrilho C, Valenti C et al (2000) Is TTF1 a good immunohistochemical marker to distinguish primary from metastatic lung adenocarcinomas? Pathol Res Pract 196:835–840

    Article  PubMed  CAS  Google Scholar 

  • Reyes C, Murali R, Park KJ (2015) Secondary involvement of the adnexa and uterine corpus by carcinomas of the uterine cervix: a detailed morphologic description. Int J Gynecol Pathol 34:551–563

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ricardo-Gonzalez RR, Nguyen M, Gokden N, Sangoi AR, Presti JC, McKenney JK (2012) Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread. J Urol 187:852–855

    Article  PubMed  Google Scholar 

  • Riopel MA, Ronnett BM, Kurman RJ (1999) Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors. Atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol 23:617–635

    Article  PubMed  CAS  Google Scholar 

  • Robboy SJ, Scully RE, Norris HJ (1974) Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer (Phila) 33:798–811

    Article  CAS  Google Scholar 

  • Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME (1995a) Pseudomyxoma peritonei in women. A clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential. Hum Pathol 26:509–524

    Article  PubMed  CAS  Google Scholar 

  • Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM (1995b) Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to “pseudomyxoma peritonei”. Am J Surg Pathol 19:1390–1408

    Article  PubMed  CAS  Google Scholar 

  • Ronnett BM, Kurman RJ, Shmookler BM, Sugarbaker PH, Young RH (1997) The morphologic spectrum of ovarian metastases of appendiceal adenocarcinomas. A clinicopathologic and immunohistochemical analysis of tumors often misinterpreted as primary ovarian tumors or metastatic tumors from other gastrointestinal sites. Am J Surg Pathol 2:1144–1155

    Article  Google Scholar 

  • Ronnett BM, Yemelyanova AV, Vang R, Gilks CB, Miller D, Gravitt PE, Kurman RJ (2008) Endocervical adenocarcinomas with ovarian metastases. Analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol 32:1835–1853

    Article  PubMed  Google Scholar 

  • Saphir O (1951) Signet-ring cell carcinoma. Mil Surg 109:360–369

    PubMed  CAS  Google Scholar 

  • Schultheis AM, Ng CK, De Filippo MR, Piscuoglio S, Macedo GS, Gatius S, Perez Mies B, Soslow RA, Lim RS, Viale A, Huberman KH, Palacios JC, Reis-Filho JS, Matias-Guiu, Weigelt B (2016) Massively parallel sequencing-based clonality analysis of synchronous endometrioid endometrial and ovarian carcinomas. J Natl Cancer Inst 108:djv427. https://doi.org/10.1093/jnci/djv427

  • Scully RE, Richardson GS (1961) Luteinization of the stroma of metastatic cancer involving the ovary and its endocrine significance. Cancer (Phila) 14:827–840

    Article  CAS  Google Scholar 

  • Seidman JD, Kurman RJ, Ronnett BM (2003) Incidence in routine practice with a new approach to improve intraoperative diagnosis. Primary and metastatic mucinous adenocarcinomas in the ovaries. Am J Surg Pathol 27:985–993

    Article  PubMed  Google Scholar 

  • Shimada M, Kigawa J, Nishimura R, Yamaguchi S, Kuzuya K, Nakanishi T, Suzuki M, Kita T, Iwasaka T, Terakawa N (2006) Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol 101:234–237

    Article  PubMed  Google Scholar 

  • Soslow RA, Rouse RV, Hendrickson MR, Silva EG, Longacre TA (1996) Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. Int J Gynecol Pathol 15:257–265

    Article  PubMed  CAS  Google Scholar 

  • Spencer JR, Eriksen B, Garnett JE (1993) Metastatic renal tumor presenting as ovarian clear cell carcinoma. Urology 41:582–584

    Article  PubMed  CAS  Google Scholar 

  • Stewart CJR, Brennan BA, Hammond IG et al (2005) Accuracy of frozen section in distinguishing primary ovarian neoplasia from tumors metastatic to the ovary. Int J Gynecol Pathol 24:356–362

    Article  PubMed  Google Scholar 

  • Stewart CJ, Ardakani NM, Doherty DA, Young RH (2014) An evaluation of the morphologic features of low-grade mucinous neoplasms of the appendix metastatic in the ovary, and comparison with primary ovarian mucinous tumors. Int J Gynecol Pathol 33:1–10

    Article  PubMed  Google Scholar 

  • Strosberg J, Nasir A, Cragun J, Gardner N, Kvols L (2007) Metastatic carcinoid tumor to the ovary: a clinicopathologic analysis of seventeen cases. Gynecol Oncol 106:65–68

    Article  PubMed  Google Scholar 

  • Sty JR, Kun LE, Casper JT (1980) Bone scintigraphy in neuroblastoma with ovarian metastasis. Wis Med J 79:28–29

    PubMed  Google Scholar 

  • Szych C, Staebler A, Connolly DC, Wu R, Cho KR, Ronnett BM (1999) Molecular genetic evidence supporting the clonality and appendiceal origin of pseudomyxoma peritonei in women. Am J Pathol 154:1849–1855

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tabata M, Ichinoe K, Sakuragi N, Shina Y, Yamaguchi T, Mabuchi Y (1987) Incidence of ovarian metastasis in patients with cancer of the uterine cervix. Gynecol Oncol 28:255–261

    Article  PubMed  CAS  Google Scholar 

  • Tandon RT, Jimenez-Cortez Y, Taub R, Borczuk AC (2018) Immunohistochemistry in peritoneal mesothelioma. A single-center experience of 244 cases. Arch Pathol Lab Med 142:236–242

    Article  PubMed  Google Scholar 

  • Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O’Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS (2008) Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol 32:1429–1443

    Article  PubMed  Google Scholar 

  • Toki N, Tsukamoto N, Kaku T et al (1991) Microscopic ovarian metastasis of the uterine cervical cancer. Gynecol Oncol 41:46–51

    Article  PubMed  CAS  Google Scholar 

  • Tornos C, Soslow R, Chen S et al (2005) Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol 29:1482–1489

    Article  PubMed  Google Scholar 

  • Tso PL, Bringaze WL III, Dauterive AH, Correa P, Cohn I Jr (1987) Gastric carcinoma in the young. Cancer (Phila) 59:1362–1365

    Article  CAS  Google Scholar 

  • Ulbright TM, Roth LM (1985a) Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol 16:28–34

    Article  PubMed  CAS  Google Scholar 

  • Ulbright TM, Roth LM (1985b) Secondary tumors of the ovary. In: Roth LM, Czernobilsky B (eds) Tumors and tumor-like conditions of the ovary, Contemporary issues in surgical pathology, vol 6. Churchill-Livingstone, New York, pp 129–152

    Google Scholar 

  • Ulbright TM, Roth LM, Stehman FB (1984) Secondary ovarian neoplasia. A clinicopathologic study of 35 cases. Cancer (Phila) 53:1164–1174

    Article  CAS  Google Scholar 

  • Vakiani E, Young RH, Carcangiu ML, Klimstra DS (2008) Acinar cell carcinoma of the pancreas metastatic to the ovary. A report of 4 cases. Am J Surg Pathol 32:1540–1545

    Article  PubMed  Google Scholar 

  • Vang R, Gown AM, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM (2006a) Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol 30:1130–1139

    Article  PubMed  Google Scholar 

  • Vang R, Gown AM, Wu LSF, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM (2006b) Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol 19:1421–1428

    Article  PubMed  CAS  Google Scholar 

  • Vang R, Gown AM, Zhao C, Barry TS, Isacson C, Richardson MS, Ronnett BM (2007) Ovarian mucinous tumors associated with mature cystic teratomas. Morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. Am J Surg Pathol 31:854–869

    Article  PubMed  Google Scholar 

  • Vara A, Madrigal B, Veiga M, Diaz A, Garcia J, Calvo J (1998) Bilateral ovarian metastases from renal clear cell carcinoma. Acta Oncol (Stockh) 37:379–380

    Article  CAS  Google Scholar 

  • Veras E, Srodon M, Neijstrom ES, Ronnett BM (2009) Metastatic HPV-related cervical adenocarcinomas presenting with thromboembolic events (trousseau syndrome): clinicopathologic characteristics of two cases. Int J Gynecol Pathol 28:134–139

    Article  PubMed  Google Scholar 

  • Wick MR, Lillemoe TJ, Copland GT, Swanson PE, Manivel JC, Kiang DT (1989) Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum Pathol 20:281–287

    Article  PubMed  CAS  Google Scholar 

  • Yakushiji M, Tazaki T, Nishimura H, Kato T (1987) Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases. Acta Obstet Gynaecol Jpn 39:479–485

    CAS  Google Scholar 

  • Yang C, Sun L, Zhang L, Zhou L, Zhao M, Peng Y, Niu D, Li Z, Huang X, Kang Q, Jia L, Lai J, Cao D (2018) Diagnostic utility of SATB2 in metastatic Krukenberg tumors of the ovary. An immunohistochemical study of 70 cases with comparison to CDX2, CK7, CK20, chromogranin, and synaptophysin. Am J Surg Pathol 42:160–171

    Article  PubMed  Google Scholar 

  • Yemelyanova AV, Vang R, Judson K, Wu LSF, Ronnett BM (2008) Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol 32:128–138

    Article  PubMed  Google Scholar 

  • Young RH (1995) Urachal adenocarcinoma metastatic to the ovary simulating primary mucinous cystadenocarcinoma of the ovary: report of a case. Virchows Arch 426:529–532

    Article  PubMed  CAS  Google Scholar 

  • Young RH (2004) Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. Semin Diagn Pathol 21:134–150

    Article  PubMed  Google Scholar 

  • Young RH (2006) From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part I. Historical perspective, general principles, mucinous tumors including the Krukenberg tumor. Adv Anat Pathol 13:205–227

    Article  PubMed  Google Scholar 

  • Young RH (2007) From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol 14:149–177

    Article  PubMed  Google Scholar 

  • Young RH, Hart WR (1989) Metastases from carcinomas of the pancreas simulating primary mucinous tumors of the ovary: a report of seven cases. Am J Surg Pathol 13:748–756

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Hart WR (1992) Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. Int J Gynecol Pathol 11:96–104

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Hart WR (1998) Metastatic intestinal carcinomas simulating primary ovarian clear cell carcinoma and secretory endometrioid carcinoma. A clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 22:805–815

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1985) Ovarian metastases from cancer of the lung: problems in interpretation – a report of seven cases. Gynecol Oncol 21:337–350

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1988a) Urothelial and ovarian carcinomas of identical cell types: problems in interpretation. A report of three cases and review of the literature. Int J Gynecol Pathol 7:197–211

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1988b) Mucinous tumors of the ovary associated with mucinous adenocarcinomas of the cervix. A clinicopathological analysis of 16 cases. Int J Gynecol Pathol 7:99–111

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1989) Alveolar rhabdomyosarcoma metastatic to the ovary. A report of two cases and discussion of the differential diagnosis of small cell malignant tumors of the ovary Cancer (Phila) 64:899–904

    CAS  Google Scholar 

  • Young RH, Scully RE (1990a) Ovarian metastases from carcinoma of the gallbladder and extrahepatic bile ducts simulating primary tumors of the ovary: a report of six cases. Int J Gynecol Pathol 9:60–72

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1990b) Sarcomas metastatic to the ovary. A report of 21 cases. Int J Gynecol Pathol 9:231–252

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1991a) Metastatic tumors in the ovary: a problem-oriented approach and review of the recent literature. Semin Diagn Pathol 8:250–276

    PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1991b) Malignant melanoma metastatic to the ovary: a clinicopathologic analysis of 20 cases. Am J Surg Pathol 15:849–860

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (2001) Differential diagnosis of ovarian tumors based primarily on their patterns and cell types. Semin Diagn Pathol 18:161–235

    PubMed  CAS  Google Scholar 

  • Young RH, Carey RW, Robboy SJ (1981) Breast carcinoma masquerading as a primary ovarian neoplasm. Cancer (Phila) 48:210–212

    Article  CAS  Google Scholar 

  • Young RH, Prat J, Scully RE (1984) Endometrial stromal sarcomas of the ovary. A clinicopathologic analysis of 23 cases. Cancer (Phila) 53:1143–1155

    Article  CAS  Google Scholar 

  • Young RH, Gilks CB, Scully RE (1991) Mucinous tumors of the appendix associated with mucinous tumors of the ovary and pseudomyxoma peritonei: a clinicopathological analysis of 22 cases supporting an origin in the appendix. Am J Surg Pathol 15:415–429

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Gersell DJ, Clement PB, Scully RE (1992a) Hepatocellular carcinoma metastatic to the ovary: a report of three cases discovered during life with discussion of the differential diagnosis of hepatoid tumors of the ovary. Hum Pathol 23:574–580

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Eichhorn JH, Dickersin GR, Scully RE (1992b) Ovarian involvement by the intra-abdominal desmoplastic small round cell tumor with divergent differentiation. A report of three cases. Hum Pathol 23:454–464

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Kozakewich HPW, Scully RE (1993a) Metastatic ovarian tumors in children: a report of 14 cases and review of the literature. Int J Gynecol Pathol 12:8–19

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Gersell DJ, Roth LM, Scully RE (1993b) Ovarian metastases from cervical carcinomas other than pure adenocarcinomas: a report of 12 cases. Cancer (Phila) 71:407–418

    Article  CAS  Google Scholar 

  • Young RH, Jackson A, Wells M (1994) Ovarian metastasis from thyroid carcinoma twelve years after partial thyroidectomy mimicking struma ovarii. Report of a case. Int J Gynecol Pathol 13:181–185

    Article  PubMed  CAS  Google Scholar 

  • Yu TJ, Iwasaki I, Horie H, Tamaru J, Takahashi A (1986) Endolymphatic stromal myosis of the uterus with metastasis to ovary and recurrence in vagina. Acta Pathol Jpn 36:301–308

    PubMed  CAS  Google Scholar 

  • Zaino RJ, Unger ER, Whitney C (1984) Synchronous carcinomas of the uterine corpus and ovary. Gynecol Oncol 19:329–335

    Article  PubMed  CAS  Google Scholar 

  • Zaloudek C, Miller TR, Stern JL (1995) Desmoplastic small cell tumor of the ovary: a unique polyphenotypic tumor with an unfavorable prognosis. Int J Gynecol Oncol 14:260–265

    CAS  Google Scholar 

  • Zamecnik M, Voltr L, Stuk J, Chlumska A (2008) Krukenberg tumor with yolk sac tumor differentiation. Int J Gynecol Pathol 27:223–228

    PubMed  Google Scholar 

  • Zhang PJ, Gao HG, Pasha TL, Litzky L, LiVolsi V (2009) TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol 28:10–18

    Article  PubMed  Google Scholar 

  • Zukerberg LR, Young RH (1990) Chordoma metastatic to the ovary: report of a case. Arch Path Lab Med 114:208–210

    PubMed  CAS  Google Scholar 

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Lerwill, M.F., Young, R.H. (2018). Metastatic Tumors of the Ovary. In: Kurman, R., Hedrick Ellenson, L., Ronnett, B. (eds) Blaustein's Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3165-7_18-2

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