Abstract
This chapter deals with neoplasms of the uterus in which there is mesenchymal differentiation. Purely mesenchymal tumors, such as those derived from smooth muscle and endometrial stroma, are considered, as are some benign and malignant neoplasms containing mixtures of epithelium and connective tissue. The categories used here are slightly modified from the comprehensive classification of mesenchymal neoplasms of the uterus developed by the World Health Organization (WHO) (Kurman et al. 2014), shown in Table 1.
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References
Abeler VM, Nenodovic M (2011) Diagnostic immunohistochemistry in uterine sarcomas: a study of 397 cases. Int J Gynecol Pathol 30:236–243. https://doi.org/10.1097/PGP.0b013e318200caff
Abeler VM, Royne O, Thoresen S, Danielsen HE, Nesland JM, Kristensen GB (2009) Uterine sarcomas in Norway. A histopathological and prognostic survey of a total population from 1970 to 2000 including 419 patients. Histopathology 54:355–364. https://doi.org/10.1111/j.1365-2559.2009.03231.x
Abell MR (1971) Papillary adenofibroma of the uterine cervix. Am J Obstet Gynecol 110:990–993
Abrams J, Talcott J, Corson JM (1989) Pulmonary metastases in patients with low-grade endometrial stromal sarcoma. Clinicopathologic findings with immunohistochemical characterization. Am J Surg Pathol 13:133–140
Abu-Rustum NR, Curtin JP, Burt M, Jones WB (1997) Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy. Obstet Gynecol 89:850–852
Abushahin N, Zhang T, Chiang S, Zhang X, Hatch K, Zheng W (2011) Serous endometrial intraepithelial carcinoma arising in adenomyosis: a report of 5 cases. Int J Gynecol Pathol 30:271–281. https://doi.org/10.1097/PGP.0b013e318200868e
Adamson GD (1992) Treatment of uterine fibroids: current findings with gonadotropin-releasing hormone agonists. Am J Obstet Gynecol 166:746–751
Adany R, Fodor F, Molnar P, Ablin RJ, Muszbek L (1990) Increased density of histiocytes in uterine leiomyomas. Int J Gynecol Pathol 9:137–144
Agaram NP et al (2015) Dichotomy of genetic abnormalities in PEComas with therapeutic implications. Am J Surg Pathol 39:813–825. https://doi.org/10.1097/pas.0000000000000389
Aggarwal N, Bhargava R, Elishaev E (2012) Uterine adenosarcomas: diagnostic use of the proliferation marker ki-67 as an adjunct to morphologic diagnosis. Int J Gynecol Pathol 31:447–452. https://doi.org/10.1097/PGP.0b013e318249285b
Agoff SN, Grieco VS, Garcia R, Gown AM (2001) Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. Appl Immunohistochem Mol Morphol 9:164–169
Ahmad AK et al (2014) Institutional review of primary non-hodgkin lymphoma of the female genital tract: a 33-year experience. Int J Gynecol Cancer 24:1250–1255. https://doi.org/10.1097/igc.0000000000000201
Ahrens WA, Folpe AL (2011) CD1a immunopositivity in perivascular epithelioid cell neoplasms: true expression or technical artifact? A streptavidin-biotin and polymer-based detection system immunohistochemical study of perivascular epithelioid cell neoplasms and their morphologic mimics. Hum Pathol 42:369–374. https://doi.org/10.1016/j.humpath.2010.09.001
Aisagbonhi O, Harrison B, Zhao L, Osgood R, Chebib I, Oliva E (2017) YWHAE rearrangement in a purely conventional low-grade endometrial stromal sarcoma that transformed over time to high-grade sarcoma: importance of molecular testing. Int J Gynecol Pathol. https://doi.org/10.1097/PGP.0000000000000451
Akahira J et al (2006) Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma. Oncology 71:333–340. https://doi.org/10.1159/000107107
Akbulut M, Zekioglu O, Terek MC, Ozdemir N (2008) Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor. Arch Gynecol Obstet 278:283–286. https://doi.org/10.1007/s00404-008-0572-0
Albrektsen G, Heuch I, Wik E, Salvesen HB (2009) Prognostic impact of parity in 493 uterine sarcoma patients. Int J Gynecol Cancer 19:1062–1067. https://doi.org/10.1111/IGC.0b013e3181aaa950. 00009577-200908000-00013 [pii]
Ali RH et al (2014) Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait. Hum Pathol 45:2453–2462. https://doi.org/10.1016/j.humpath.2014.08.012. S0046-8177(14)00356-6 [pii]
Alsolami S et al (2014) Current morphologic criteria perform poorly in identifying hereditary leiomyomatosis and renal cell carcinoma syndrome-associated uterine leiomyomas. Int J Gynecol Pathol 33:560–567. https://doi.org/10.1097/pgp.0000000000000091
Amada S, Nakano H, Tsuneyoshi M (1995) Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: a comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p53 expression, DNA flow cytometry, and muscle specific actins. Int J Gynecol Pathol 14:134–142
Amant F et al (2004) Immunohistochemical determination of estrogen and progesterone receptor positivity in uterine adenosarcoma. Gynecol Oncol 93:680–685. https://doi.org/10.1016/j.ygyno.2004.03.021. S0090825804001921 [pii]
Amant F, Woestenborghs H, Vandenbroucke V, Berteloot P, Neven P, Moerman P, Vergote I (2006) Transition of endometrial stromal sarcoma into high-grade sarcoma. Gynecol Oncol 103:1137–1140. https://doi.org/10.1016/j.ygyno.2006.07.013
Amant F et al (2007) Clinical study investigating the role of lymphadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma. Br J Cancer 97:1194–1199. https://doi.org/10.1038/sj.bjc.6603986
Amant F, Tousseyn T, Coenegrachts L, Decloedt J, Moerman P, Debiec-Rychter M (2011) Case report of a poorly differentiated uterine tumour with t(10;17) translocation and neuroectodermal phenotype. Anticancer Res 31:2367–2371. 31/6/2367 [pii]
American Cancer Society (2017) Survival rates of uterine sarcoma by stage. Cited 5 Jun 2017. www.cancer.org/cancer/uterine-sarcoma/detection-diagnosis-staging/survival-rates.html
Andersen J (1998) Factors in fibroid growth. Baillieres Clin Obstet Gynaecol 12:225–243
Argani P et al (2001) Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol 159:179–192. https://doi.org/10.1016/s0002-9440(10)61684-7
Argani P, Lal P, Hutchinson B, Lui MY, Reuter VE, Ladanyi M (2003) Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay. Am J Surg Pathol 27:750–761
Argani P, Zhong M, Reuter VE, Fallon JT, Epstein JI, Netto GJ, Antonescu CR (2016) TFE3-fusion variant analysis defines specific clinicopathologic associations among Xp11 translocation cancers. Am J Surg Pathol 40:723–737. https://doi.org/10.1097/pas.0000000000000631
Arias-Stella JA, Lewis N, Benayed R, Oliva E, Young R, Hoang L, Lee C-H, Jungbluth A, Soslow R, Antonescu C, Ladanyi M, Chiang S (2018) Novel PLAG1 gene rearrangement distinguishes uterine myxoid leiomyosarcoma from other uterine myxoid mesenchymal tumors. Paper presented at the United States and Canadian Academy of Pathology (USCAP) 107th annual meeting, Vancouver
Atkins KA, Bell ME, Kempson RL, Hendrickson MR (2001) Epithelioid smooth muscle neoplasms of the uterus. Mod Pathol 14:132A
Atkins KA, Arronte N, Darus CJ, Rice LW (2008) The use of p16 in enhancing the histologic classification of uterine smooth muscle tumors. Am J Surg Pathol 32:98–102. https://doi.org/10.1097/PAS.0b013e3181574d1e
Attygalle AD et al (2017) An unusual case of YWHAE-NUTM2A/B endometrial stromal sarcoma with confinement to the endometrium and lack of high-grade morphology. Int J Gynecol Pathol 36:165–171. https://doi.org/10.1097/PGP.0000000000000286
Aubry MC, Myers JL, Colby TV, Leslie KO, Tazelaar HD (2002) Endometrial stromal sarcoma metastatic to the lung: a detailed analysis of 16 patients. Am J Surg Pathol 26:440–449
Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM (2003) High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol 188:100–107
Baker P, Oliva E (2007) Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. J Clin Pathol 60:235–243
Baker RJ, Hildebrandt RH, Rouse RV, Hendrickson MR, Longacre TA (1999) Inhibin and CD99 (MIC2) expression in uterine stromal neoplasms with sex-cord-like elements. Hum Pathol 30:671–679
Baker PM, Moch H, Oliva E (2005) Unusual morphologic features of endometrial stromal tumors: a report of 2 cases. Am J Surg Pathol 29:1394–1398. 00000478-200510000-00018 [pii]
Baldi GG et al (2013) Solitary fibrous tumor of all sites: outcome of late recurrences in 14 patients. Clin Sarcoma Res 3:4. https://doi.org/10.1186/2045-3329-3-4
Balleine RL, Earls PJ, Webster LR, Mote PA, deFazio A, Harnett PR, Clarke CL (2004) Expression of progesterone receptor A and B isoforms in low-grade endometrial stromal sarcoma. Int J Gynecol Pathol 23:138–144. 00004347-200404000-00008 [pii]
Bardella C et al (2011) Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol 225:4–11. https://doi.org/10.1002/path.2932
Barlin JN et al (2015) Molecular subtypes of uterine leiomyosarcoma and correlation with clinical outcome. Neoplasia 17:183–189. https://doi.org/10.1016/j.neo.2014.12.007
Barlow JF et al (1983) Myxoid tumor of the uterus and right atrial myxomas. S D J Med 36:9–13
Barney B, Tward JD, Skidmore T, Gaffney DK (2009) Does radiotherapy or lymphadenectomy improve survival in endometrial stromal sarcoma? Int J Gynecol Cancer 19:1232–1238. https://doi.org/10.1111/IGC.0b013e3181b33c9a. 00009577-200910000-00015 [pii]
Bartosch C, Exposito MI, Lopes JM (2010) Low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma: a comparative analysis emphasizing the importance of distinguishing between these two groups. Int J Surg Pathol 18:286–291. https://doi.org/10.1177/1066896909337600
Beer TW, Buchanan R, Buckley CH (1995) Uterine stromal sarcoma following tamoxifen treatment. J Clin Pathol 48:596
Bekkers RL, Willemsen WN, Schijf CP, Massuger LF, Bulten J, Merkus JM (1999) Leiomyomatosis peritonealis disseminata: does malignant transformation occur? A literature review. Gynecol Oncol 75:158–163. https://doi.org/10.1006/gyno.1999.5490
Bell SW, Kempson RL, Hendrickson MR (1994) Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 18:535–558
Bennett JA, Lamb C, Young RH (2016) Apoplectic leiomyomas: a morphologic analysis of 100 cases highlighting unusual features. Am J Surg Pathol 40:563–568. https://doi.org/10.1097/pas.0000000000000569
Bennett JA, Nardi V, Rouzbahman M, Morales-Oyarvide V, Nielsen GP, Oliva E (2017a) Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum. Mod Pathol 30:1489–1503. https://doi.org/10.1038/modpathol.2017.69
Bennett JA et al (2017b) Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases. Mod Pathol 30:1476–1488. https://doi.org/10.1038/modpathol.2017.56
Bergeron C, Amant F, Ferenczy A (2006) Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511–521
Bernard B et al (2013) Uterine adenosarcomas: a dual-institution update on staging, prognosis and survival. Gynecol Oncol 131:634–639. https://doi.org/10.1016/j.ygyno.2013.09.011
Bertsch E et al (2014) MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. Mod Pathol 27:1144–1153. https://doi.org/10.1038/modpathol.2013.243
Binder SW, Nieberg RK, Cheng L, al-Jitawi S (1991) Histologic and immunohistochemical analysis of nine endometrial stromal tumors: an unexpected high frequency of keratin protein positivity. Int J Gynecol Pathol 10:191–197
Blake EA, Sheridan TB, Wang KL, Takiuchi T, Kodama M, Sawada K, Matsuo K (2014) Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature. Eur J Obstet Gynecol Reprod Biol 181:163–170. https://doi.org/10.1016/j.ejogrb.2014.07.050
Blattner JM, Gable P, Quigley MM, McHale MT (2007) Primitive neuroectodermal tumor of the uterus. Gynecol Oncol 106:419–422
Blom R, Guerrieri C (1999) Adenosarcoma of the uterus: a clinicopathologic, DNA flow cytometric, p53 and mdm-2 analysis of 11 cases. Int J Gynecol Cancer 9:37–43
Blom R, Guerrieri C, Stal O, Malmstrom H, Simonsen E (1998) Leiomyosarcoma of the uterus: a clinicopathologic, DNA flow cytometric, p53, and mdm-2 analysis of 49 cases. Gynecol Oncol 68:54–61
Bodner K et al (2001) Prognostic parameters in endometrial stromal sarcoma: a clinicopathologic study in 31 patients. Gynecol Oncol 81:160–165. https://doi.org/10.1006/gyno.2001.6152. S0090-8258(01)96152-9 [pii]
Bodner K, Bodner-Adler B, Kimberger O, Czerwenka K, Mayerhofer K (2004) Estrogen and progesterone receptor expression in patients with uterine smooth muscle tumors. Fertil Steril 81:1062–1066. https://doi.org/10.1016/j.fertnstert.2003.08.043
Bodner-Adler B, Bodner K, Czerwenka K, Kimberger O, Leodolter S, Mayerhofer K (2005) Expression of p16 protein in patients with uterine smooth muscle tumors: an immunohistochemical analysis. Gynecol Oncol 96:62–66. https://doi.org/10.1016/j.ygyno.2004.09.026
Bogani G et al (2016) Morcellator’s port-site metastasis of a uterine smooth muscle tumor of uncertain malignant potential after minimally invasive myomectomy. J Minim Invasive Gynecol 23:647–649. https://doi.org/10.1016/j.jmig.2016.01.021
Borahay MA, Al-Hendy A, Kilic GS, Boehning D (2015) Signaling pathways in leiomyoma: understanding pathobiology and implications for therapy. Mol Med 21:242–256. https://doi.org/10.2119/molmed.2014.00053
Botsis D, Koliopoulos C, Kondi-Pafitis A, Creatsas G (2005) Frequency, histological, and immunohistochemical properties of massive inflammatory lymphocytic infiltration of leiomyomas of the uterus: an entity causing diagnostic difficulties. Int J Gynecol Pathol 24:326–329
Bouchard-Fortier G, Kim RH, Allen L, Gupta A, May T (2016) Fertility-sparing surgery for the management of young women with embryonal rhabdomyosarcoma of the cervix: a case series. Gynecol Oncol Rep 18:4–7. https://doi.org/10.1016/j.gore.2016.08.004
Brescia RJ, Tazelaar HD, Hobbs J, Miller AW (1989) Intravascular lipoleiomyomatosis: a report of two cases. Hum Pathol 20:252–256
Brooks JJ, Wells GB, Yeh IT, LiVolsi VA (1992) Bizarre epithelioid lipoleiomyoma of the uterus. Int J Gynecol Pathol 11:144–149
Brooks SE, Zhan M, Cote T, Baquet CR (2004) Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989–1999. Gynecol Oncol 93:204–208. https://doi.org/10.1016/j.ygyno.2003.12.029
Brown DC, Theaker JM, Banks PM, Gatter KC, Mason DY (1987) Cytokeratin expression in smooth muscle and smooth muscle tumours. Histopathology 11:477–486
Buelow B, Cohen J, Nagymanyoki Z, Frizzell N, Joseph NM, McCalmont T, Garg K (2016) Immunohistochemistry for 2-Succinocysteine (2SC) and fumarate hydratase (FH) in cutaneous leiomyomas may aid in identification of patients with HLRCC (Hereditary leiomyomatosis and renal cell carcinoma syndrome). Am J Surg Pathol 40:982–988. https://doi.org/10.1097/pas.0000000000000626
Bukulmez O, Doody KJ (2006) Clinical features of myomas. Obstet Gynecol Clin N Am 33:69–84. https://doi.org/10.1016/j.ogc.2005.12.002
Burch DM, Tavassoli FA (2011) Myxoid leiomyosarcoma of the uterus. Histopathology 59:1144–1155. https://doi.org/10.1111/j.1365-2559.2011.04053.x
Busca A, Parra-Herran C (2016) Hemangiomas of the uterine cervix: association with abnormal bleeding and pain in young women and hormone receptor expression. Report of four cases and review of the literature. Pathol Res Pract 212:532–538. https://doi.org/10.1016/j.prp.2016.03.003
Busca A, Parra-Herran C (2017) Myxoid mesenchymal tumors of the uterus: an update on classification, definitions, and differential diagnosis. Adv Anat Pathol 24:354–361. https://doi.org/10.1097/pap.0000000000000164
Busca A, Gulavita P, Parra-Herran C, Islam S (2017) IFITM1 outperforms CD10 in differentiating low-grade endometrial stromal sarcomas from smooth muscle neoplasms of the uterus. Int J Gynecol Pathol. https://doi.org/10.1097/PGP.0000000000000424
Buza N, Xu F, Wu W, Carr RJ, Li P, Hui P (2014) Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study. Hum Pathol 45:1885–1892. https://doi.org/10.1016/j.humpath.2014.05.010
Cardinale L, Mirra M, Galli C, Goldblum JR, Pizzolitto S, Falconieri G (2008) Angiosarcoma of the uterus: report of 2 new cases with deviant clinicopathologic features and review of the literature. Ann Diagn Pathol 12:217–221. https://doi.org/10.1016/j.anndiagpath.2007.08.001. S1092-9134(07)00123-2 [pii]
Carroll A et al (2014) Uterine adenosarcoma: an analysis on management, outcomes, and risk factors for recurrence. Gynecol Oncol 135:455–461. https://doi.org/10.1016/j.ygyno.2014.10.022
Casey S, McCluggage WG (2015) Adenomyomas of the uterine cervix: report of a cohort including endocervical and novel variants [corrected]. Histopathology 66:420–429. https://doi.org/10.1111/his.12546
Chan JK, Kawar NM, Shin JY, Osann K, Chen LM, Powell CB, Kapp DS (2008) Endometrial stromal sarcoma: a population-based analysis. Br J Cancer 99:1210–1215. https://doi.org/10.1038/sj.bjc.6604527
Chang V, Aikawa M, Druet R (1977) Uterine leiomyoblastoma: ultrastructural and cytological studies. Cancer 39:1563–1569
Chang KL, Crabtree GS, Lim-Tan SK, Kempson RL, Hendrickson MR (1990) Primary uterine endometrial stromal neoplasms. A clinicopathologic study of 117 cases. Am J Surg Pathol 14:415–438
Charville GW et al (2016) PAX7 expression in rhabdomyosarcoma, related soft tissue tumors, and small round blue cell neoplasms. Am J Surg Pathol 40:1305–1315. https://doi.org/10.1097/pas.0000000000000717
Chauveinc L et al (1999) Uterine sarcomas: the Curie Institut experience. Prognosis factors and adjuvant treatments. Gynecol Oncol 72:232–237. https://doi.org/10.1006/gyno.1998.5251. S0090-8258(98)95251-9 [pii]
Chen KT (1999) Uterine leiomyohibernoma. Int J Gynecol Pathol 18:96–97
Chen L, Yang B (2008) Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. Int J Gynecol Pathol 27:326–332. https://doi.org/10.1097/PGP.0b013e31815ea7f5
Cheung AN, Ng WF, Chung LP, Khoo US (1996) Mixed low grade and high grade endometrial stromal sarcoma of uterus: differences on immunohistochemistry and chromosome in situ hybridisation. J Clin Pathol 49:604–607
Chew I, Oliva E (2010) Endometrial stromal sarcomas: a review of potential prognostic factors. Adv Anat Pathol 17:113–121. https://doi.org/10.1097/PAP.0b013e3181cfb7c2. 00125480-201003000-00003 [pii]
Chiang S et al (2011) Frequency of known gene rearrangements in endometrial stromal tumors. Am J Surg Pathol 35:1364–1372. https://doi.org/10.1097/PAS.0b013e3182262743
Chiang S et al (2015) FOXL2 mutation is absent in uterine tumors resembling ovarian sex cord tumors. Am J Surg Pathol 39:618–623. https://doi.org/10.1097/pas.0000000000000367
Chiang S et al (2017a) BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology. Mod Pathol 30:1251–1261. https://doi.org/10.1038/modpathol.2017.42
Chiang S et al (2017b) Primitive neuroectodermal tumors of the female genital tract: a morphologic, immunohistochemical, and molecular study of 19 cases. Am J Surg Pathol 41:761–772. https://doi.org/10.1097/pas.0000000000000831
Chiang S et al (2018) NTRK fusions define a novel uterine sarcoma subtype with features of fibrosarcoma. Am J Surg Pathol 42:791–798. https://doi.org/10.1097/pas.0000000000001055
Cho KR, Woodruff JD, Epstein JI (1989) Leiomyoma of the uterus with multiple extrauterine smooth muscle tumors: a case report suggesting multifocal origin. Hum Pathol 20:80–83
Choi YJ et al (2015) Genomic landscape of endometrial stromal sarcoma of uterus. Oncotarget 6:33319–33328. https://doi.org/10.18632/oncotarget.5384
Chou WY, Chang HW (2012) Uterine hemangioma: a rare pathologic entity. Arch Pathol Lab Med 136:567–571. https://doi.org/10.5858/arpa.2011-0078-RS
Chow KL et al (2017) The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study. Histopathology 70:746–755. https://doi.org/10.1111/his.13124
Christacos NC, Quade BJ, Dal Cin P, Morton CC (2006) Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic features. Genes Chromosomes Cancer 45:304–312. https://doi.org/10.1002/gcc.20291
Chu P, Arber DA (2000) Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Pathol 113:374–382. https://doi.org/10.1309/8vav-j2fu-8cu9-ek18
Chu PG, Arber DA, Weiss LM, Chang KL (2001) Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors: an immunohistochemical comparison of 34 cases. Mod Pathol 14:465–471. https://doi.org/10.1038/modpathol.3880335
Chu MC, Mor G, Lim C, Zheng W, Parkash V, Schwartz PE (2003) Low-grade endometrial stromal sarcoma: hormonal aspects. Gynecol Oncol 90:170–176. S0090825803002580 [pii]
Clement PB (1988) Intravenous leiomyomatosis of the uterus. Pathol Annu 23 Pt 2:153–183
Clement PB (1989) Mullerian adenosarcomas of the uterus with sarcomatous overgrowth. A clinicopathological analysis of 10 cases. Am J Surg Pathol 13:28–38
Clement PB (2000) The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors: a selective review with emphasis on recent advances. Int J Gynecol Pathol 19:39–55
Clement PB (2007) The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects. Adv Anat Pathol 14:241–260. https://doi.org/10.1097/PAP.0b013e3180ca7d7b
Clement PB, Scully RE (1974) Mullerian adenosarcoma of the uterus. A clinicopathologic analysis of ten cases of a distinctive type of mullerian mixed tumor. Cancer 34:1138–1149
Clement PB, Scully RE (1976) Uterine tumors resembling ovarian sex-cord tumors. A clinicopathologic analysis of fourteen cases. Am J Clin Pathol 66:512–525
Clement PB, Scully RE (1989) Mullerian adenosarcomas of the uterus with sex cord-like elements. A clinicopathologic analysis of eight cases. Am J Clin Pathol 91:664–672
Clement PB, Scully RE (1990a) Mullerian adenofibroma of the uterus with invasion of myometrium and pelvic veins. Int J Gynecol Pathol 9:363–371
Clement PB, Scully RE (1990b) Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol 21:363–381
Clement PB, Scully RE (1992) Endometrial stromal sarcomas of the uterus with extensive endometrioid glandular differentiation: a report of three cases that caused problems in differential diagnosis. Int J Gynecol Pathol 11:163–173
Clement PB, Young RH, Scully RE (1988) Intravenous leiomyomatosis of the uterus. A clinicopathological analysis of 16 cases with unusual histologic features. Am J Surg Pathol 12:932–945
Clement PB, Young RH, Scully RE (1992) Diffuse, perinodular, and other patterns of hydropic degeneration within and adjacent to uterine leiomyomas. Problems in differential diagnosis. Am J Surg Pathol 16:26–32
Coad JE, Sulaiman RA, Das K, Staley N (1997) Perinodular hydropic degeneration of a uterine leiomyoma: a diagnostic challenge. Hum Pathol 28:249–251
Coard KC, Fletcher HM (2002) Leiomyosarcoma of the uterus with a florid intravascular component (“intravenous leiomyosarcomatosis”). Int J Gynecol Pathol 21:182–185
Cohen DT, Oliva E, Hahn PF, Fuller AF Jr, Lee SI (2007) Uterine smooth-muscle tumors with unusual growth patterns: imaging with pathologic correlation. AJR Am J Roentgenol 188:246–255. https://doi.org/10.2214/ajr.05.1070
Conlon N, Soslow RA, Murali R (2015) Perivascular epithelioid tumours (PEComas) of the gynaecological tract. J Clin Pathol 68:418–426. https://doi.org/10.1136/jclinpath-2015-202945
Cramer SF, Patel A (1990) The frequency of uterine leiomyomas. Am J Clin Pathol 94:435–438
Cramer SF, Horiszny J, Patel A, Sigrist S (1996) The relation of fibrous degeneration to menopausal status in small uterine leiomyomas with evidence for postmenopausal origin of seedling myomas. Mod Pathol 9:774–780
Croce S, Chibon F (2015) MED12 and uterine smooth muscle oncogenesis: state of the art and perspectives. Eur J Cancer 51:1603–1610. https://doi.org/10.1016/j.ejca.2015.04.023
Croce S et al (2013) YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations. Mod Pathol 26:1390–1400. https://doi.org/10.1038/modpathol.2013.69
Croce S, Young RH, Oliva E (2014) Uterine leiomyomas with bizarre nuclei: a clinicopathologic study of 59 cases. Am J Surg Pathol 38:1330–1339. https://doi.org/10.1097/pas.0000000000000249
Croce S et al (2015) Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. Mod Pathol 28:1001–1010. https://doi.org/10.1038/modpathol.2015.3
Croce S, de Kock L, Boshari T, Hostein I, Velasco V, Foulkes WD, McCluggage WG (2016) Uterine tumor resembling ovarian sex cord tumor (UTROSCT) commonly exhibits positivity with sex cord markers FOXL2 and SF-1 but lacks FOXL2 and DICER1 mutations. Int J Gynecol Pathol 35:301–308. https://doi.org/10.1097/pgp.0000000000000240
Crow J, Wilkins M, Howe S, More L, Helliwell P (1991) Mast cells in the female genital tract. Int J Gynecol Pathol 10:230–237
Cui RR, Wright JD (2016) Risk of occult uterine sarcoma in presumed uterine fibroids. Clin Obstet Gynecol 59:103–118. https://doi.org/10.1097/grf.0000000000000163
D’Angelo E, Prat J (2010) Uterine sarcomas: a review. Gynecol Oncol 116:131–139. https://doi.org/10.1016/j.ygyno.2009.09.023. S0090-8258(09)00722-7 [pii]
D’Angelo E, Ali RH, Espinosa I, Lee CH, Huntsman DG, Gilks B, Prat J (2013) Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement. Am J Surg Pathol 37:514–521. https://doi.org/10.1097/PAS.0b013e318272c612
Dal Cin P, Aly MS, De Wever I, Moerman P, Van Den Berghe H (1992) Endometrial stromal sarcoma t(7;17)(p15-21;q12-21) is a nonrandom chromosome change. Cancer Genet Cytogenet 63:43–46. 0165-4608(92)90062-D [pii]
Darby AJ, Papadaki L, Beilby JO (1975) An unusual leiomyosarcoma of the uterus containing osteoclast-like giant cells. Cancer 36:495–504
Davidson B et al (2014) Gene expression signatures of primary and metastatic uterine leiomyosarcoma. Hum Pathol 45:691–700. https://doi.org/10.1016/j.humpath.2013.11.003
Daya DA, Scully RE (1988) Sarcoma botryoides of the uterine cervix in young women: a clinicopathological study of 13 cases. Gynecol Oncol 29:290–304
De Fusco PA, Gaffey TA, Malkasian GD Jr, Long HJ, Cha SS (1989) Endometrial stromal sarcoma: review of Mayo Clinic experience, 1945–1980. Gynecol Oncol 35:8–14
de Leval L, Waltregny D, Boniver J, Young RH, Castronovo V, Oliva E (2006) Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus. Am J Surg Pathol 30:319–327. https://doi.org/10.1097/01.pas.0000188029.63706.31. 00000478-200603000-00004 [pii]
de Leval L, Lim GS, Waltregny D, Oliva E (2010) Diverse phenotypic profile of uterine tumors resembling ovarian sex cord tumors: an immunohistochemical study of 12 cases. Am J Surg Pathol 34:1749–1761. https://doi.org/10.1097/PAS.0b013e3181f8120c
de Vos S, Wilczynski SP, Fleischhacker M, Koeffler P (1994) p53 alterations in uterine leiomyosarcomas versus leiomyomas. Gynecol Oncol 54:205–208. https://doi.org/10.1006/gyno.1994.1194
Dehner LP, Jarzembowski JA, Hill DA (2012) Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations. Mod Pathol 25:602–614. https://doi.org/10.1038/modpathol.2011.185
Devaney K, Tavassoli FA (1991) Immunohistochemistry as a diagnostic aid in the interpretation of unusual mesenchymal tumors of the uterus. Mod Pathol 4:225–231
Dewaele B et al (2014) Identification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma. Int J Cancer 134:1112–1122. https://doi.org/10.1002/ijc.28440
Dgani R et al (1998) Clinical-pathological study of uterine leiomyomas with high mitotic activity. Acta Obstet Gynecol Scand 77:74–77
Dharkar DD, Kraft JR, Gangadharam D (1981) Uterine lipomas. Arch Pathol Lab Med 105:43–45
Dimmler A, Seitz G, Hohenberger W, Kirchner T, Faller G (2003) Late pulmonary metastasis in uterine PEComa. J Clin Pathol 56:627–628
Dionigi A, Oliva E, Clement PB, Young RH (2002) Endometrial stromal nodules and endometrial stromal tumors with limited infiltration: a clinicopathologic study of 50 cases. Am J Surg Pathol 26:567–581
Dos Santos LA et al (2011) Incidence of lymph node and adnexal metastasis in endometrial stromal sarcoma. Gynecol Oncol 121:319–322. https://doi.org/10.1016/j.ygyno.2010.12.363. S0090-8258(10)01270-9 [pii]
Downes KA, Hart WR (1997) Bizarre leiomyomas of the uterus: a comprehensive pathologic study of 24 cases with long-term follow-up. Am J Surg Pathol 21:1261–1270
Due W, Pickartz H (1989) Immunohistologic detection of estrogen and progesterone receptors in disseminated peritoneal leiomyomatosis. Int J Gynecol Pathol 8:46–53
Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F (2002) Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas. Am J Obstet Gynecol 186:409–415
Dundr P, Mara M, Maskova J, Fucikova Z, Povysil C, Tvrdik D (2006) Pathological findings of uterine leiomyomas and adenomyosis following uterine artery embolization. Pathol Res Pract 202:721–729. https://doi.org/10.1016/j.prp.2006.07.001
Eddy GL, Mazur MT (1997) Endolymphatic stromal myosis associated with tamoxifen use. Gynecol Oncol 64:262–264. https://doi.org/10.1006/gyno.1996.4552. S0090-8258(96)94552-7 [pii]
Eichhorn JH, Young RH, Clement PB (1996) Sertoliform endometrial adenocarcinoma: a study of four cases. Int J Gynecol Pathol 15:119–126
Elshafie M, Rahimi S, Ganesan R, Hirschowitz L (2013) Mullerian adenosarcoma arising in a subserosal adenomyoma. Int J Surg Pathol 21:186–189. https://doi.org/10.1177/1066896912453852
Euscher ED, Deavers MT, Lopez-Terrada D, Lazar AJ, Silva EG, Malpica A (2008) Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literature. Am J Surg Pathol 32:219–228. https://doi.org/10.1097/PAS.0b013e318093e421
Evans HL (1982) Endometrial stromal sarcoma and poorly differentiated endometrial sarcoma. Cancer 50:2170–2182
Evans AT 3rd, Symmonds RE, Gaffey TA (1981) Recurrent pelvic intravenous leiomyomatosis. Obstet Gynecol 57:260–264
Evans HL, Chawla SP, Simpson C, Finn KP (1988) Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors. Cancer 62:2239–2247
Eyden BP, Hale RJ, Richmond I, Buckley CH (1992) Cytoskeletal filaments in the smooth muscle cells of uterine leiomyomata and myometrium: an ultrastructural and immunohistochemical analysis. Virchows Arch A Pathol Anat Histopathol 420:51–58
Fadare O (2008) Perivascular epithelioid cell tumor (PEComa) of the uterus: an outcome-based clinicopathologic analysis of 41 reported cases. Adv Anat Pathol 15:63–75. https://doi.org/10.1097/PAP.0b013e31816613b0
Fadare O (2011) Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review. Adv Anat Pathol 18:60–74. https://doi.org/10.1097/PAP.0b013e3182026be7
Fadare O, McCalip B, Mariappan MR, Hileeto D, Parkash V (2005) An endometrial stromal tumor with osteoclast-like giant cells. Ann Diagn Pathol 9:160–165. S109291340500033X [pii]
Fadare O, Bonvicino A, Martel M, Renshaw IL, Azodi M, Parkash V (2010) Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. Int J Gynecol Pathol 29:122–134. https://doi.org/10.1097/PGP.0b013e3181bc98c0. 00004347-201003000-00005 [pii]
Farhood AI, Abrams J (1991) Immunohistochemistry of endometrial stromal sarcoma. Hum Pathol 22:224–230
Fekete PS, Vellios F (1984) The clinical and histologic spectrum of endometrial stromal neoplasms: a report of 41 cases. Int J Gynecol Pathol 3:198–212
Felix AS et al (2013) The etiology of uterine sarcomas: a pooled analysis of the epidemiology of endometrial cancer consortium. Br J Cancer 108:727–734. https://doi.org/10.1038/bjc.2013.2
Feng W, Hua K, Malpica A, Zhou X, Baak JP (2013a) Stages I to II WHO 2003-defined low-grade endometrial stromal sarcoma: how much primary therapy is needed and how little is enough? Int J Gynecol Cancer 23:488–493. https://doi.org/10.1097/IGC.0b013e318247aa14. 00009577-201303000-00015 [pii]
Feng W, Malpica A, Robboy SJ, Gudlaugsson E, Hua K, Zhou X, Baak JP (2013b) Prognostic value of the diagnostic criteria distinguishing endometrial stromal sarcoma, low grade from undifferentiated endometrial sarcoma, 2 entities within the invasive endometrial stromal neoplasia family. Int J Gynecol Pathol 32:299–306. https://doi.org/10.1097/PGP.0b013e318229adfb
Feng W et al (2013c) Can proliferation biomarkers reliably predict recurrence in World Health Organization 2003 defined endometrial stromal sarcoma, low grade? PLoS One 8:e75899. https://doi.org/10.1371/journal.pone.0075899. PONE-D-13-18388 [pii]
Feng W, Malpica A, Yinhua Y, Janssen E, Gudlaugsson E, Zhou X, Baak JP (2013d) Diagnostic and prognostic morphometric features in WHO 2003 invasive endometrial stromal tumours. Histopathology 62:688–694. https://doi.org/10.1111/j.1365-2559.2011.04120.x
Ferguson SE, Gerald W, Barakat RR, Chi DS, Soslow RA (2007) Clinicopathologic features of rhabdomyosarcoma of gynecologic origin in adults. Am J Surg Pathol 31:382–389
Ferry JA, Harris NL, Scully RE (1989) Uterine leiomyomas with lymphoid infiltration simulating lymphoma: a report of seven cases. Int J Gynecol Pathol 8:263–270
Fitko R, Brainer J, Schink JC, August CZ (1990) Endometrial stromal sarcoma with rhabdoid differentiation. Int J Gynecol Pathol 9:379–382
Fleming WP, Peters WA, Kumar NB, Morley GW (1984) Autopsy findings in patients with uterine sarcoma. Gynecol Oncol 19:168–172
Fleming H, Ostor AG, Pickel H, Fortune DW (1989) Arteriovenous malformations of the uterus. Obstet Gynecol 73:209–214
Flicker K, Smolle E, Haybaeck J, Moinfar F (2015) Genomic characterization of endometrial stromal sarcomas with array comparative genomic hybridization. Exp Mol Pathol 98:367–374. https://doi.org/10.1016/j.yexmp.2015.03.009. S0014-4800(15)00044-1 [pii]
Flierman PA, Oberye JJ, van der Hulst VP, de Blok S (2005) Rapid reduction of leiomyoma volume during treatment with the GnRH antagonist ganirelix. BJOG 112:638–642. https://doi.org/10.1111/j.1471-0528.2004.00504.x
Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW (2005) Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol 29:1558–1575
Fornelli A, Pasquinelli G, Eusebi V (1999) Leiomyoma of the uterus showing skeletal muscle differentiation: a case report. Hum Pathol 30:356–359
Franquemont DW, Frierson HF Jr, Mills SE (1991) An immunohistochemical study of normal endometrial stroma and endometrial stromal neoplasms. Evidence for smooth muscle differentiation. Am J Surg Pathol 15:861–870
Frey NV et al (2006) Primary lymphomas of the cervix and uterus: the University of Pennsylvania’s experience and a review of the literature. Leuk Lymphoma 47:1894–1901. https://doi.org/10.1080/10428190600687653. U8R528Q43L276436 [pii]
Fuehrer NE, Keeney GL, Ketterling RP, Knudson RA, Bell DA (2012) ALK-1 protein expression and ALK gene rearrangements aid in the diagnosis of inflammatory myofibroblastic tumors of the female genital tract. Arch Pathol Lab Med 136:623–626. https://doi.org/10.5858/arpa.2011-0341-OA
Fukunaga M (2005) Perivascular epithelioid cell tumor of the uterus: report of four cases. Int J Gynecol Pathol 24:341–346
Fukunaga M (2011) Pure alveolar rhabdomyosarcoma of the uterine corpus. Pathol Int 61:377–381. https://doi.org/10.1111/j.1440-1827.2011.02672.x
Fukunaga M, Endo Y (1996) Pelvic bone involvement in low-grade endometrial stromal sarcoma with ovarian sex cord-like differentiation. Histopathology 29:391–393
Fukunaga M, Ushigome S (1998) Dissecting leiomyoma of the uterus with extrauterine extension. Histopathology 32:160–164
Fukunaga M, Miyazawa Y, Ushigome S (1997) Endometrial low-grade stromal sarcoma with ovarian sex cord-like differentiation: report of two cases with an immunohistochemical and flow cytometric study. Pathol Int 47:412–415
Gadducci A et al (1996a) Uterine leiomyosarcoma: analysis of treatment failures and survival. Gynecol Oncol 62:25–32. https://doi.org/10.1006/gyno.1996.0185
Gadducci A et al (1996b) Endometrial stromal sarcoma: analysis of treatment failures and survival. Gynecol Oncol 63:247–253. https://doi.org/10.1006/gyno.1996.0314. S0090-8258(96)90314-5 [pii]
Gadducci A, Cosio S, Romanini A, Genazzani AR (2008) The management of patients with uterine sarcoma: a debated clinical challenge. Crit Rev Oncol Hematol 65:129–142. https://doi.org/10.1016/j.critrevonc.2007.06.011
Gal AA, Brooks JS, Pietra GG (1989) Leiomyomatous neoplasms of the lung: a clinical, histologic, and immunohistochemical study. Mod Pathol 2:209–216
Gallardo A, Prat J (2009) Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. Am J Surg Pathol 33:278–288. https://doi.org/10.1097/PAS.0b013e318181a80d
Gannon BR, Manduch M, Childs TJ (2008) Differential Immunoreactivity of p16 in leiomyosarcomas and leiomyoma variants. Int J Gynecol Pathol 27:68–73. https://doi.org/10.1097/pgp.0b013e3180ca954f
Garcia MG, Deavers MT, Knoblock RJ, Chen W, Tsimberidou AM, Manning JT Jr, Medeiros LJ (2006) Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature. Am J Clin Pathol 125:783–790
Gard GB, Mulvany NJ, Quinn MA (1999) Management of uterine leiomyosarcoma in Australia. Aust N Z J Obstet Gynaecol 39:93–98
Gardie B et al (2011) Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma. J Med Genet 48:226–234. https://doi.org/10.1136/jmg.2010.085068
Garg K, Tickoo SK, Soslow RA, Reuter VE (2011) Morphologic features of uterine leiomyomas associated with hereditary leiomyomatosis and renal cell carcinoma syndrome: a case report. Am J Surg Pathol 35:1235–1237. https://doi.org/10.1097/PAS.0b013e318223ca01
Gersell DJ, Fulling KH (1989) Localized neurofibromatosis of the female genitourinary tract. Am J Surg Pathol 13:873–878
Geyer JT, Ferry JA, Harris NL, Young RH, Longtine JA, Zukerberg LR (2010) Florid reactive lymphoid hyperplasia of the lower female genital tract (lymphoma-like lesion): a benign condition that frequently harbors clonal immunoglobulin heavy chain gene rearrangements. Am J Surg Pathol 34:161–168. https://doi.org/10.1097/PAS.0b013e3181cc4f12
Gil-Benso R, Lopez-Gines C, Navarro S, Carda C, Llombart-Bosch A (1999) Endometrial stromal sarcomas: immunohistochemical, electron microscopical and cytogenetic findings in two cases. Virchows Arch 434:307–314
Gilks CB, Taylor GP, Clement PB (1987) Inflammatory pseudotumor of the uterus. Int J Gynecol Pathol 6:275–286
Gilks CB, Young RH, Clement PB, Hart WR, Scully RE (1996) Adenomyomas of the uterine cervix of of endocervical type: a report of ten cases of a benign cervical tumor that may be confused with adenoma malignum [corrected]. Mod Pathol 9:220–224
Gilks CB, Clement PB, Hart WR, Young RH (2000) Uterine adenomyomas excluding atypical polypoid adenomyomas and adenomyomas of endocervical type: a clinicopathologic study of 30 cases of an underemphasized lesion that may cause diagnostic problems with brief consideration of adenomyomas of other female genital tract sites. Int J Gynecol Pathol 19:195–205
Giner F, Compan A, Monteagudo C (2012) Uterine glomeruloid hemangioma in a patient without POEMS syndrome. Int J Surg Pathol 20:407–410. https://doi.org/10.1177/1066896911429297
Gisser SD, Young I (1977) Neurilemoma-like uterine myomas: an ultrastructural reaffirmation of their non-Schwannian nature. Am J Obstet Gynecol 129:389–392
Giuntoli RL 2nd, Bristow RE (2004) Uterine leiomyosarcoma: present management. Curr Opin Oncol 16:324–327
Giuntoli RL 2nd, Metzinger DS, DiMarco CS, Cha SS, Sloan JA, Keeney GL, Gostout BS (2003) Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy. Gynecol Oncol 89:460–469
Giuntoli RL 2nd, Gostout BS, DiMarco CS, Metzinger DS, Keeney GL (2007) Diagnostic criteria for uterine smooth muscle tumors: leiomyoma variants associated with malignant behavior. J Reprod Med 52:1001–1010
Goldberg MF, Hurt WG, Frable WJ (1977) Leiomyomatosis peritonealis disseminata. Report of a case and review of the literature. Obstet Gynecol 49:46–52
Goldblum JR, Clement PB, Hart WR (1995) Adenomyosis with sparse glands: a potential mimic of low-grade endometrial stromal sarcoma. Am J Clin Pathol 103:218–223
Gomez-Laencina AM, Martinez Diaz F, Izquierdo Sanjuanes B, Vicente Sanchez EM, Fernandez Salmeron R, Meseguer Pena F (2012) Localized neurofibromatosis of the female genital system: a case report and review of the literature. J Obstet Gynaecol Res 38:953–956. https://doi.org/10.1111/j.1447-0756.2011.01816.x
Goncharova EA et al (2002) Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem 277:30958–30967. https://doi.org/10.1074/jbc.M202678200
Goode B et al (2018) Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol 31:660–673. https://doi.org/10.1038/modpathol.2017.153
Gordts S, Grimbizis G, Campo R (2018) Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertil Steril 109:380–388.e381. https://doi.org/10.1016/j.fertnstert.2018.01.006
Gown AM, Boyd HC, Chang Y, Ferguson M, Reichler B, Tippens D (1988) Smooth muscle cells can express cytokeratins of “simple” epithelium. Immunocytochemical and biochemical studies in vitro and in vivo. Am J Pathol 132:223–232
Grayson W, Fourie J, Tiltman AJ (1998) Xanthomatous leiomyosarcoma of the uterine cervix. Int J Gynecol Pathol 17:89–90
Greene LA, Mount SL, Schned AR, Cooper K (2003) Recurrent perivascular epithelioid cell tumor of the uterus (PEComa): an immunohistochemical study and review of the literature. Gynecol Oncol 90:677–681
Gremel G et al (2015) A prognosis based classification of undifferentiated uterine sarcomas: identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival. Int J Cancer 136:1608–1618. https://doi.org/10.1002/ijc.29141
Grignon DJ, Carey MR, Kirk ME, Robinson ML (1987) Diffuse uterine leiomyomatosis: a case study with pregnancy complicated by intrapartum hemorrhage. Obstet Gynecol 69:477–480
Gross KL et al (2004) Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studies. Genes Chromosomes Cancer 41:183–190. https://doi.org/10.1002/gcc.20079
Gunnala V et al (2017) Novel fumarate hydratase mutation in siblings with early onset uterine leiomyomas and hereditary leiomyomatosis and renal cell cancer syndrome. Int J Gynecol Pathol. https://doi.org/10.1097/pgp.0000000000000423
Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A (2009) Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis. Gynecol Oncol 113:324–326. https://doi.org/10.1016/j.ygyno.2009.02.020
Guo X et al (2015) Clinically relevant molecular subtypes in leiomyosarcoma. Clin Cancer Res 21:3501–3511. https://doi.org/10.1158/1078-0432.ccr-14-3141
Gyure KA, Hart WR, Kennedy AW (1995) Lymphangiomyomatosis of the uterus associated with tuberous sclerosis and malignant neoplasia of the female genital tract: a report of two cases. Int J Gynecol Pathol 14:344–351
Haimes JD et al (2017) Uterine inflammatory myofibroblastic tumors frequently harbor ALK fusions with IGFBP5 and THBS1. Am J Surg Pathol 41:773–780. https://doi.org/10.1097/pas.0000000000000801
Halaska MJ, Haidopoulos D, Guyon F, Morice P, Zapardiel I, Kesic V (2017) European Society of gynecological oncology statement on fibroid and uterine morcellation. Int J Gynecol Cancer 27:189–192. https://doi.org/10.1097/igc.0000000000000911
Halbwedl I et al (2005) Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. Gynecol Oncol 97:582–587. https://doi.org/10.1016/j.ygyno.2005.01.002. S0090-8258(05)00022-3 [pii]
Hales HA, Peterson CM, Jones KP, Quinn JD (1992) Leiomyomatosis peritonealis disseminata treated with a gonadotropin-releasing hormone agonist. A case report. Am J Obstet Gynecol 167:515–516
Hall KL et al (1997) Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomas. Gynecol Oncol 65:330–335. https://doi.org/10.1006/gyno.1997.4653
Hall T, Lee SI, Boruta DM, Goodman A (2015) Medical device safety and surgical dissemination of unrecognized uterine malignancy: morcellation in minimally invasive gynecologic surgery. Oncologist 20:1274–1282. https://doi.org/10.1634/theoncologist.2015-0061
Han HS, Park IA, Kim SH, Lee HP (1998) The clear cell variant of epithelioid intravenous leiomyomatosis of the uterus: report of a case. Pathol Int 48:892–896
Harris NL, Scully RE (1984) Malignant lymphoma and granulocytic sarcoma of the uterus and vagina. A clinicopathologic analysis of 27 cases. Cancer 53:2530–2545
Hart WR, Yoonessi M (1977) Endometrial stromatosis of the uterus. Obstet Gynecol 49:393–403
Hattab EM, Allam-Nandyala P, Rhatigan RM (1999) The stromal component of large endometrial polyps. Int J Gynecol Pathol 18:332–337
Hayashi T et al (2011) Prevalence of uterine and adnexal involvement in pulmonary lymphangioleiomyomatosis: a clinicopathologic study of 10 patients. Am J Surg Pathol 35:1776–1785. https://doi.org/10.1097/PAS.0b013e318235edbd
Heatley MK (2006) Atypical polypoid adenomyoma: a systematic review of the English literature. Histopathology 48:609–610
Heerema-McKenney A et al (2008) Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma: a tissue microarray study of 71 primary tumors including correlation with molecular phenotype. Am J Surg Pathol 32:1513–1522
Hemming ML, Wagner AJ, Nucci MR, Chiang S, Wang L, Hensley ML, George S (2017) YWHAE-rearranged high-grade endometrial stromal sarcoma: two-center case series and response to chemotherapy. Gynecol Oncol 145:531–535. https://doi.org/10.1016/j.ygyno.2017.03.021. S0090-8258(17)30237-8 [pii]
Hendrickson MR, Tavassoli F, Kempson RL, McCluggage G, Hailer U, Kubik-Huch RA (2003) Mesenchymal tumours and related lesions. In: Tavassoli F, Devilee P (eds) World Health Organization classification of tumours. Pathology and genetics of tumors of breast and female genital organs. IARC Press, Lyon, pp 233–244
Hennig Y, Caselitz J, Bartnitzke S, Bullerdiek J (1997) A third case of a low-grade endometrial stromal sarcoma with a t(7;17)(p14 approximately 21;q11.2 approximately 21). Cancer Genet Cytogenet 98:84–86
Hensley ML (2017) Difficult choices in stage I uterine leiomyosarcoma- it’s okay to “stand there”. Gynecol Oncol 147:1–2. https://doi.org/10.1016/j.ygyno.2017.09.004
Hensley ML et al (2002) Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial. J Clin Oncol 20:2824–2831. https://doi.org/10.1200/jco.2002.11.050
Hensley ML, Blessing JA, DeGeest K, Abulafia O, Rose PG, Homesley HD (2008a) Fixed-dose rate gemcitabine plus docetaxel as second-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase II study. Gynecol Oncol 109:323–328. https://doi.org/10.1016/j.ygyno.2008.02.024
Hensley ML, Blessing JA, Mannel R, Rose PG (2008b) Fixed-dose rate gemcitabine plus docetaxel as first-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase II trial. Gynecol Oncol 109:329–334. https://doi.org/10.1016/j.ygyno.2008.03.010
Hillard JB, Malpica A, Ramirez PT (2004) Conservative management of a uterine tumor resembling an ovarian sex cord-stromal tumor. Gynecol Oncol 92:347–352
Hilsenbeck SG, Allred DC (1992) Improved methods of estimating mitotic activity in solid tumors. Hum Pathol 23:601–602
Hirschfield L, Kahn LB, Chen S, Winkler B, Rosenberg S (1986) Mullerian adenosarcoma with ovarian sex cord-like differentiation. A light- and electron-microscopic study. Cancer 57:1197–1200
Hirschowitz L, Mayall FG, Ganesan R, McCluggage WG (2013) Intravascular adenomyomatosis: expanding the morphologic spectrum of intravascular leiomyomatosis. Am J Surg Pathol 37:1395–1400. https://doi.org/10.1097/PAS.0b013e31828b2c99. 00000478-201309000-00013 [pii]
Hoang LN et al (2017) Novel high-grade endometrial stromal sarcoma: a morphologic mimicker of myxoid leiomyosarcoma. Am J Surg Pathol 41:12–24. https://doi.org/10.1097/pas.0000000000000721
Hoang L, Chiang S, Lee CH (2018) Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. Pathology 50:162–177. https://doi.org/10.1016/j.pathol.2017.11.086. S0031-3025(17)30393-8 [pii]
Hodgson A, Amemiya Y, Seth A, Djordjevic B, Parra-Herran C (2017) High-grade mullerian adenosarcoma: genomic and clinicopathologic characterization of a distinct neoplasm with prevalent TP53 pathway alterations and aggressive behavior. Am J Surg Pathol 41:1513–1522. https://doi.org/10.1097/pas.0000000000000907
Holzmann C, Markowski DN, Bartnitzke S, Koczan D, Helmke BM, Bullerdiek J (2015) A rare coincidence of different types of driver mutations among uterine leiomyomas (UL). Mol Cytogenet 8:76. https://doi.org/10.1186/s13039-015-0177-9
Horie Y, Ikawa S, Kadowaki K, Minagawa Y, Kigawa J, Terakawa N (1995) Lipoadenofibroma of the uterine corpus: report of a new variant of adenofibroma (benign mÅllerian mixed tumor). Arch Pathol Lab Med 119:274–276
Hornick JL, Fletcher CD (2008) Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol 32:493–501. https://doi.org/10.1097/PAS.0b013e318161dc34
Horstmann JP, Pietra GG, Harman JA, Cole NG, Grinspan S (1977) Spontaneous regression of pulmonary leiomyomas during pregnancy. Cancer 39:314–321
Houghton JP, McCluggage WG (2007) Embryonal rhabdomyosarcoma of the cervix with focal pleomorphic areas. J Clin Pathol 60:88–89
Howitt BE, Quade BJ, Nucci MR (2015a) Uterine polyps with features overlapping with those of mullerian adenosarcoma: a clinicopathologic analysis of 29 cases emphasizing their likely benign nature. Am J Surg Pathol 39:116–126. https://doi.org/10.1097/pas.0000000000000303
Howitt BE et al (2015b) Targeted genomic analysis of mullerian adenosarcoma. J Pathol 235:37–49. https://doi.org/10.1002/path.4442
Howitt BE, Dal Cin P, Nucci MR, Quade BJ (2016) Involvement of chromosome 8 in mullerian adenosarcoma. Int J Gynecol Pathol. https://doi.org/10.1097/PGP.0000000000000287
Hrzenjak A (2016) JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas. Orphanet J Rare Dis 11:15. https://doi.org/10.1186/s13023-016-0400-8
Huang HY, Ladanyi M, Soslow RA (2004) Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. Am J Surg Pathol 28:224–232
Hung YP, Fletcher CD, Hornick JL (2016) Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. Mod Pathol 29:370–380. https://doi.org/10.1038/modpathol.2016.31
Hurrell DP, McCluggage WG (2005) Uterine leiomyosarcoma with HMB45+ clear cell areas: report of two cases. Histopathology 47:540–542
Hurrell DP, McCluggage WG (2007) Uterine tumour resembling ovarian sex cord tumour is an immunohistochemically polyphenotypic neoplasm which exhibits coexpression of epithelial, myoid and sex cord markers. J Clin Pathol 60:1148–1154. https://doi.org/10.1136/jcp.2006.044842
Hyde KE, Geisinger KR, Marshall RB, Jones TL (1989) The clear-cell variant of uterine epithelioid leiomyoma. An immunohistologic and ultrastructural study. Arch Pathol Lab Med 113:551–553
Hyman DM, Grisham RN, Hensley ML (2014) Management of advanced uterine leiomyosarcoma. Curr Opin Oncol 26:422–427. https://doi.org/10.1097/cco.0000000000000094
Iasonos A et al (2013) External validation of a prognostic nomogram for overall survival in women with uterine leiomyosarcoma. Cancer 119:1816–1822. https://doi.org/10.1002/cncr.27971
Ip PP, Cheung AN, Clement PB (2009) Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol 33:992–1005. https://doi.org/10.1097/PAS.0b013e3181a02d1c
Irving JA, Carinelli S, Prat J (2006) Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation. Mod Pathol 19:17–24. https://doi.org/10.1038/modpathol.3800475
Ito H, Sasaki N, Miyagawa K, Tahara E (1986) Bizarre leiomyoblastoma of the cervix uteri. Immunohistochemical and ultrastructural study. Acta Pathol Jpn 36:1737–1745
Jabbour MN, Seoud M, Al-Ahmadie H, Abdul-Karim FW, Zaatari GS (2014) ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma. Int J Gynecol Pathol 33:263–267. https://doi.org/10.1097/PGP.0b013e318290407c
Jakate K et al (2013) Endometrial sarcomas: an immunohistochemical and JAZF1 re-arrangement study in low-grade and undifferentiated tumors. Mod Pathol 26:95–105. https://doi.org/10.1038/modpathol.2012.136
Jautzke G, Muller-Ruchholtz E, Thalmann U (1996) Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. Pathol Res Pract 192:215–223. https://doi.org/10.1016/s0344-0338(96)80224-x
Jones MW, Lefkowitz M (1995) Adenosarcoma of the uterine cervix: a clinicopathological study of 12 cases. Int J Gynecol Pathol 14:223–229
Jones MW, Norris HJ (1995) Clinicopathologic study of 28 uterine leiomyosarcomas with metastasis. Int J Gynecol Pathol 14:243–249
Joseph NM, Solomon DA, Frizzell N, Rabban JT, Zaloudek C, Garg K (2015) Morphology and immunohistochemistry for 2SC and FH aid in detection of fumarate hydratase gene aberrations in uterine leiomyomas from young patients. Am J Surg Pathol 39:1529–1539. https://doi.org/10.1097/pas.0000000000000520
Jung CK, Jung JH, Lee A, Lee YS, Choi YJ, Yoon SK, Lee KY (2008) Diagnostic use of nuclear beta-catenin expression for the assessment of endometrial stromal tumors. Mod Pathol 21:756–763. https://doi.org/10.1038/modpathol.2008.53
Kaku T, Silverberg SG, Major FJ, Miller A, Fetter B, Brady MF (1992) Adenosarcoma of the uterus: a Gynecologic Oncology Group clinicopathologic study of 31 cases. Int J Gynecol Pathol 11:75–88
Kaminski PF, Tavassoli FA (1984) Plexiform tumorlet: a clinical and pathologic study of 15 cases with ultrastructural observations. Int J Gynecol Pathol 3:124–134
Karpathiou G, Dal P, Chauleur C, Peoc’h M (2018) Intravascular lymphocytic accumulation in the uterine cervix: a frequent finding. Int J Gynecol Pathol 37:229–232. https://doi.org/10.1097/pgp.0000000000000407
Kasashima S, Kobayashi M, Yamada M, Oda Y (2003) Myxoid endometrial stromal sarcoma of the uterus. Pathol Int 53:637–641. 1525 [pii]
Kasashima S, Minato H, Kobayashi M, Ueda Y, Oda Y, Hashimoto S, Inoue M (2007) Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors. APMIS 115:861–865. https://doi.org/10.1111/j.1600-0463.2007.apm_635.x
Kawaguchi K, Fujii S, Konishi I, Nanbu Y, Nonogaki H, Mori T (1989) Mitotic activity in uterine leiomyomas during the menstrual cycle. Am J Obstet Gynecol 160:637–641
Keel SB, Clement PB, Prat J, Young RH (1998) Malignant schwannoma of the uterine cervix: a study of three cases. Int J Gynecol Pathol 17:223–230
Kempson RL, Hendrickson MR (2000) Smooth muscle, endometrial stromal, and mixed mullerian tumors of the uterus. Mod Pathol 13:328–342. https://doi.org/10.1038/modpathol.3880055
Kenny SL, McCluggage WG (2014) Adenomyomatous polyp of the endometrium with prominent epithelioid smooth muscle differentiation: report of two cases of a hitherto undescribed lesion. Int J Surg Pathol 22:358–363. https://doi.org/10.1177/1066896913499630
Kho KA, Lin K, Hechanova M, Richardson DL (2016) Risk of occult uterine sarcoma in women undergoing hysterectomy for benign indications. Obstet Gynecol 127:468–473. https://doi.org/10.1097/aog.0000000000001242
Kibar Y, Aydin A, Deniz H, Balat O, Cebesoy B, Al-Nafussi A (2008) A rare case of low-grade endometrial stromal sarcoma with myxoid differentiation and atypical bizarre cells. Eur J Gynaecol Oncol 29:397–398
Kim YH, Cho H, Kyeom-Kim H, Kim I (1996) Uterine endometrial stromal sarcoma with rhabdoid and smooth muscle differentiation. J Korean Med Sci 11:88–93
Kim HS, Yoon G, Jung YY, Lee YY, Song SY (2015) Fibromyxoid variant of endometrial stromal sarcoma with atypical bizarre nuclei. Int J Clin Exp Pathol 8:3316–3321
King ME, Dickersin GR, Scully RE (1982) Myxoid leiomyosarcoma of the uterus. A report of six cases. Am J Surg Pathol 6:589–598
Kjerulff KH, Langenberg P, Seidman JD, Stolley PD, Guzinski GM (1996) Uterine leiomyomas. Racial differences in severity, symptoms and age at diagnosis. J Reprod Med 41:483–490
Koike N, Tsunemi T, Uekuri C, Akasaka J, Ito F, Shigemitsu A, Kobayashi H (2013) Pathogenesis and malignant transformation of adenomyosis (review). Oncol Rep 29:861–867. https://doi.org/10.3892/or.2012.2184
Koivisto-Korander R, Butzow R, Koivisto A, Leminen A (2008) Clinical outcome and prognostic factors in 100 cases of uterine sarcoma: experience in Helsinki University Central Hospital 1990–2001. Gynecol Oncol 111:74–81
Kokawa K, Yamoto M, Yata C, Mabuchi Y, Umesaki N (2002) Postmenopausal intravenous leiomyomatosis with high levels of estradiol and estrogen receptor. Obstet Gynecol 100:1124–1126
Kolin DL et al (2018) SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma. Mod Pathol. https://doi.org/10.1038/s41379-018-0049-z
Koontz JI et al (2001) Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A 98:6348–6353. https://doi.org/10.1073/pnas.101132598. 98/11/6348. [pii]
Kosari F, Daneshbod Y, Parwaresch R, Krams M, Wacker HH (2005) Lymphomas of the female genital tract: a study of 186 cases and review of the literature. Am J Surg Pathol 29:1512–1520
Koshiyama M et al (2002) Adenocarcinomas arising from uterine adenomyosis: a report of four cases. Int J Gynecol Pathol 21:239–245
Kriseman ML, Wang WL, Sullinger J, Schmeler KM, Ramirez PT, Herzog CE, Frumovitz M (2012) Rhabdomyosarcoma of the cervix in adult women and younger patients. Gynecol Oncol 126:351–356. https://doi.org/10.1016/j.ygyno.2012.05.008
Krivak TC, Seidman JD, McBroom JW, MacKoul PJ, Aye LM, Rose GS (2001) Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival. Gynecol Oncol 83:89–94
Kruse AJ, Croce S, Kruitwagen RF, Riedl RG, Slangen BF, Van Gorp T, Van de Vijver KK (2014a) Aggressive behavior and poor prognosis of endometrial stromal sarcomas with YWHAE-FAM22 rearrangement indicate the clinical importance to recognize this subset. Int J Gynecol Cancer 24:1616–1622. https://doi.org/10.1097/IGC.0000000000000278
Kruse AJ, Sep S, Slangen BF, Vandevijver NM, Van Gorp T, Kruitwagen RF, Van de Vijver KK (2014b) Angiosarcomas of primary gynecologic origin: a clinicopathologic review and quantitative analysis of survival. Int J Gynecol Cancer 24:4–12. https://doi.org/10.1097/igc.0000000000000020
Kunzel KE, Mills NZ, Muderspach LI, d’Ablaing G 3rd (1993) Myxoid leiomyosarcoma of the uterus. Gynecol Oncol 48:277–280. https://doi.org/10.1006/gyno.1993.1048
Kurihara S et al (2008) Endometrial stromal sarcomas and related high-grade sarcomas: immunohistochemical and molecular genetic study of 31 cases. Am J Surg Pathol 32:1228–1238. https://doi.org/10.1097/PAS.0b013e31816a3b42
Kurihara S, Oda Y, Ohishi Y, Kaneki E, Kobayashi H, Wake N, Tsuneyoshi M (2010) Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas. Mod Pathol 23:225–234. https://doi.org/10.1038/modpathol.2009.162
Kurman RJ, Norris HJ (1976) Mesenchymal tumors of the uterus. VI. Epithelioid smooth muscle tumors including leiomyoblastoma and clear-cell leiomyoma: a clinical and pathologic analysis of 26 cases. Cancer 37:1853–1865
Kurman RJ, Carcangiu ML, Herrington CS, Young RH (2014) WHO classification of tumours of female reproductive organs. World Health Organization classification of tumours, 4th edn. IARC Press, Lyon
Ladanyi M et al (2001) The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene 20:48–57. https://doi.org/10.1038/sj.onc.1204074
Lai FM, Wong FW, Allen PW (1991) Diffuse uterine leiomyomatosis with hemorrhage. Arch Pathol Lab Med 115:834–837
Lakhman Y et al (2017) Differentiation of uterine leiomyosarcoma from atypical leiomyoma: diagnostic accuracy of qualitative MR imaging features and feasibility of texture analysis. Eur Radiol 27:2903–2915. https://doi.org/10.1007/s00330-016-4623-9
Langlois PL (1970) The size of the normal uterus. J Reprod Med 4:220–228
Larson B, Silfversward C, Nilsson B, Pettersson F (1990) Prognostic factors in uterine leiomyosarcoma. A clinical and histopathological study of 143 cases. The Radiumhemmet series 1936–1981. Acta Oncol 29:185–191
Launonen V et al (2001) Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A 98:3387–3392. https://doi.org/10.1073/pnas.051633798
Layfield LJ, Liu K, Dodge R, Barsky SH (2000) Uterine smooth muscle tumors: utility of classification by proliferation, ploidy, and prognostic markers versus traditional histopathology. Arch Pathol Lab Med 124:221–227. https://doi.org/10.1043/0003-9985(2000)124<0221:usmt>2.0.co;2
Leath CA 3rd et al (2007) A multi-institutional review of outcomes of endometrial stromal sarcoma. Gynecol Oncol 105:630–634. https://doi.org/10.1016/j.ygyno.2007.01.031. S0090-8258(07)00056-X [pii]
Lee HJ, Choi J, Kim KR (2008) Pulmonary benign metastasizing leiomyoma associated with intravenous leiomyomatosis of the uterus: clinical behavior and genomic changes supporting a transportation theory. Int J Gynecol Pathol 27:340–345. https://doi.org/10.1097/PGP.0b013e3181656dab
Lee CH, Turbin DA, Sung YC, Espinosa I, Montgomery K, van de Rijn M, Gilks CB (2009) A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors. Mod Pathol 22:1519–1531. https://doi.org/10.1038/modpathol.2009.122
Lee CH et al (2012a) Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. Am J Surg Pathol 36:1562–1570. https://doi.org/10.1097/PAS.0b013e31825fa931. 00000478-201210000-00018 [pii]
Lee CH et al (2012b) The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. Am J Surg Pathol 36:641–653. https://doi.org/10.1097/PAS.0b013e31824a7b1a
Lee CH et al (2012c) 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A 109:929–934. https://doi.org/10.1073/pnas.1115528109
Lee CH et al (2014) Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. Mod Pathol 27:751–757. https://doi.org/10.1038/modpathol.2013.199
Lee JC et al (2016) Genomewide copy number analysis of mullerian adenosarcoma identified chromosomal instability in the aggressive subgroup. Mod Pathol 29:1070–1082. https://doi.org/10.1038/modpathol.2016.99
Lehtonen R et al (2004) Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Am J Pathol 164:17–22. https://doi.org/10.1016/s0002-9440(10)63091-x
Lehtonen HJ et al (2006) Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet 43:523–526. https://doi.org/10.1136/jmg.2005.036400
Leibsohn S, d’Ablaing G, Mishell DR Jr, Schlaerth JB (1990) Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas. Am J Obstet Gynecol 162:968–974; discussion 974-966
Leiser AL, Anderson SE, Nonaka D, Chuai S, Olshen AB, Chi DS, Soslow RA (2006) Apoptotic and cell cycle regulatory markers in uterine leiomyosarcoma. Gynecol Oncol 101:86–91. https://doi.org/10.1016/j.ygyno.2005.09.055
Leitao MM Jr et al (2012) Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma. Gynecol Oncol 124:558–562. https://doi.org/10.1016/j.ygyno.2011.11.009
Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus. Gynecol Oncol 91:209–212
Leitao MM et al (2004) Tissue microarray immunohistochemical expression of estrogen, progesterone, and androgen receptors in uterine leiomyomata and leiomyosarcoma. Cancer 101:1455–1462. https://doi.org/10.1002/cncr.20521
Lewis N et al (2017) ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity. Mod Pathol. https://doi.org/10.1038/modpathol.2017.162
Lewis N et al (2018) ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity. Mod Pathol 31:674–684. https://doi.org/10.1038/modpathol.2017.162
Li N, Wu LY, Zhang HT, An JS, Li XG, Ma SK (2008) Treatment options in stage I endometrial stromal sarcoma: a retrospective analysis of 53 cases. Gynecol Oncol 108:306–311. https://doi.org/10.1016/j.ygyno.2007.10.023. S0090-8258(07)00863-3 [pii]
Li RF, Gupta M, McCluggage WG, Ronnett BM (2013) Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. Am J Surg Pathol 37:344–355. https://doi.org/10.1097/PAS.0b013e31826e0271
Liang SX, Patel K, Pearl M, Liu J, Zheng W, Tornos C (2007) Sertoliform endometrioid carcinoma of the endometrium with dual immunophenotypes for epithelial membrane antigen and inhibin alpha: case report and literature review. Int J Gynecol Pathol 26:291–297. https://doi.org/10.1097/01.pgp.0000236948.67087.56. 00004347-200707000-00017 [pii]
Lifschitz-Mercer B, Czernobilsky B, Dgani R, Dallenbach-Hellweg G, Moll R, Franke WW (1987) Immunocytochemical study of an endometrial diffuse clear cell stromal sarcoma and other endometrial stromal sarcomas. Cancer 59:1494–1499
Lillemoe TJ, Perrone T, Norris HJ, Dehner LP (1991) Myogenous phenotype of epithelial-like areas in endometrial stromal sarcomas. Arch Pathol Lab Med 115:215–219
Lim D, Alvarez T, Nucci MR, Gilks B, Longacre T, Soslow RA, Oliva E (2013) Interobserver variability in the interpretation of tumor cell necrosis in uterine leiomyosarcoma. Am J Surg Pathol 37:650–658. https://doi.org/10.1097/PAS.0b013e3182851162
Littell RD et al (2017) Adjuvant gemcitabine-docetaxel chemotherapy for stage I uterine leiomyosarcoma: trends and survival outcomes. Gynecol Oncol 147:11–17. https://doi.org/10.1016/j.ygyno.2017.07.122
Liu Y, Guo S, Wang L, Suzuki S, Sugimura H, Li Y (2016) Uterine angiosarcoma: a case report and literature review. Int J Gynecol Pathol 35:264–268. https://doi.org/10.1097/pgp.0000000000000219
Lloreta J, Prat J (1992) Endometrial stromal nodule with smooth and skeletal muscle components simulating stromal sarcoma. Int J Gynecol Pathol 11:293–298
Lloreta J, Prat J (1993) Ultrastructure of an endometrial stromal nodule with skeletal muscle. Ultrastruct Pathol 17:405–410
Lobel MK, Somasundaram P, Morton CC (2006) The genetic heterogeneity of uterine leiomyomata. Obstet Gynecol Clin N Am 33:13–39. https://doi.org/10.1016/j.ogc.2005.12.006
Loddenkemper C, Mechsner S, Foss HD, Dallenbach FE, Anagnostopoulos I, Ebert AD, Stein H (2003) Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumors and endometrial stromal sarcoma. Am J Surg Pathol 27:1458–1462
Longacre TA, Chung MH, Rouse RV, Hendrickson MR (1996) Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus – a clinicopathologic study of 55 cases. Am J Surg Pathol 20:1–20
Longacre TA, Hendrickson MR, Kempson RL (1997) Predicting clinical outcome for uterine smooth muscle neoplasms with a reasonable degree of certainty. Adv Anat Pathol 4:95–104
Lotgering FK, Pijpers L, van Eijck J, Wallenburg HC (1989) Pregnancy in a patient with diffuse cavernous hemangioma of the uterus. Am J Obstet Gynecol 160:628–630
Ly A, Mills AM, McKenney JK, Balzer BL, Kempson RL, Hendrickson MR, Longacre TA (2013) Atypical leiomyomas of the uterus: a clinicopathologic study of 51 cases. Am J Surg Pathol 37:643–649. https://doi.org/10.1097/PAS.0b013e3182893f36
Ma J, Shi QL, Zhou XJ, Meng K, Chen JY, Huang WB (2007) Lymphoma-like lesion of the uterine cervix: report of 12 cases of a rare entity. Int J Gynecol Pathol 26:194–198
Machida H, Nathenson MJ, Takiuchi T, Adams CL, Garcia-Sayre J, Matsuo K (2017) Significance of lymph node metastasis on survival of women with uterine adenosarcoma. Gynecol Oncol 144:524–530. https://doi.org/10.1016/j.ygyno.2017.01.012
Majmudar B, Ghanee N, Horowitz IR, Graham D (1998) Uterine arteriovenous malformation necessitating hysterectomy with bilateral salpingo-oophorectomy in a young pregnant patient. Arch Pathol Lab Med 122:842–845
Major FJ et al (1993) Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study. Cancer 71:1702–1709
Makinen N et al (2016) Exome sequencing of uterine leiomyosarcomas identifies frequent mutations in TP53, ATRX, and MED12. PLoS Genet 12:e1005850. https://doi.org/10.1371/journal.pgen.1005850
Malpica A, Deavers MT, Silva EG (2006) High grade sarcoma in endometrial stromal sarcoma: dedifferentiated endometrial stromal sarcoma [Abstract]. Modern Pathol 19:188A
Maluf HM, Gersell DJ (1994) Uterine leiomyomas with high content of mast cells. Arch Pathol Lab Med 118:712–714
Mansi JL, Ramachandra S, Wiltshaw E, Fisher C (1990) Endometrial stromal sarcomas. Gynecol Oncol 36:113–118
Marino-Enriquez A et al (2018) BCOR internal tandem duplication in high-grade uterine sarcomas. Am J Surg Pathol 42:335–341. https://doi.org/10.1097/pas.0000000000000993
Markowski DN, Bartnitzke S, Loning T, Drieschner N, Helmke BM, Bullerdiek J (2012) MED12 mutations in uterine fibroids – their relationship to cytogenetic subgroups. Int J Cancer 131:1528–1536. https://doi.org/10.1002/ijc.27424
Markowski DN, Holzmann C, Bullerdiek J (2015) Genetic alterations in uterine fibroids – a new direction for pharmacological intervention? Expert Opin Ther Targets 19:1485–1494. https://doi.org/10.1517/14728222.2015.1075510
Marsh EE, Bulun SE (2006) Steroid hormones and leiomyomas. Obstet Gynecol Clin N Am 33:59–67. https://doi.org/10.1016/j.ogc.2005.12.001
Marshall RJ, Braye SG, Jones DB (1986) Leiomyosarcoma of the uterus with giant cells resembling osteoclasts. Int J Gynecol Pathol 5:260–268
Marshburn PB, Matthews ML, Hurst BS (2006) Uterine artery embolization as a treatment option for uterine myomas. Obstet Gynecol Clin N Am 33:125–144. https://doi.org/10.1016/j.ogc.2005.12.009
Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F (2008) PEComas: the past, the present and the future. Virchows Arch 452:119–132. https://doi.org/10.1007/s00428-007-0509-1
Martin KA, Rzucidlo EM, Merenick BL, Fingar DC, Brown DJ, Wagner RJ, Powell RJ (2004) The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. Am J Physiol Cell Physiol 286:C507–C517. https://doi.org/10.1152/ajpcell.00201.2003
Martin-Reay DG, Christ ML, LaPata RE (1991) Uterine leiomyoma with skeletal muscle differentiation. Report of a case. Am J Clin Pathol 96:344–347
Matsubara A et al (2013) Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. Histopathology 62:657–661. https://doi.org/10.1111/his.12039
Mayerhofer K et al (1999) Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases. Gynecol Oncol 74:196–201. https://doi.org/10.1006/gyno.1999.5436
Mazur MT, Kraus FT (1980) Histogenesis of morphologic variations in tumors of the uterine wall. Am J Surg Pathol 4:59–74
Mazur MT, Priest JB (1986) Clear cell leiomyoma (leiomyoblastoma) of the uterus: ultrastructural observations. Ultrastruct Pathol 10:249–255
McCluggage WG (2010) Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol 17:122–129. https://doi.org/10.1097/PAP.0b013e3181cfe732
McCluggage WG (2016) A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus. Mod Pathol 29(Suppl 1):S78–S91. https://doi.org/10.1038/modpathol.2015.137
McCluggage WG, Young RH (2008) Endometrial stromal sarcomas with true papillae and pseudopapillae. Int J Gynecol Pathol 27:555–561. https://doi.org/10.1097/PGP.0b013e31817a82f9
McCluggage WG, Date A, Bharucha H, Toner PG (1996) Endometrial stromal sarcoma with sex cord-like areas and focal rhabdoid differentiation. Histopathology 29:369–374
McCluggage WG, Alderdice JM, Walsh MY (1999) Polypoid uterine lesions mimicking endometrial stromal sarcoma. J Clin Pathol 52:543–546
McCluggage WG, Ellis PK, McClure N, Walker WJ, Jackson PA, Manek S (2000) Pathologic features of uterine leiomyomas following uterine artery embolization. Int J Gynecol Pathol 19:342–347
McCluggage WG, Cromie AJ, Bryson C, Traub AI (2001a) Uterine endometrial stromal sarcoma with smooth muscle and glandular differentiation. J Clin Pathol 54:481–483
McCluggage WG, Sumathi VP, Maxwell P (2001b) CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 39:273–278
McCluggage WG, Ganesan R, Herrington CS (2009) Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis. Histopathology 54:365–373. https://doi.org/10.1111/j.1365-2559.2009.03230.x. HIS3230 [pii]
McDonald AG, Dal Cin P, Ganguly A, Campbell S, Imai Y, Rosenberg AE, Oliva E (2011) Liposarcoma arising in uterine lipoleiomyoma: a report of 3 cases and review of the literature. Am J Surg Pathol 35:221–227. https://doi.org/10.1097/PAS.0b013e31820414f7
Meenakshi M, McCluggage WG (2010) Vascular involvement in adenomyosis: report of a large series of a common phenomenon with observations on the pathogenesis of adenomyosis. Int J Gynecol Pathol 29:117–121. https://doi.org/10.1097/PGP.0b013e3181b7018d. 00004347-201003000-00004 [pii]
Mehine M et al (2013) Characterization of uterine leiomyomas by whole-genome sequencing. N Engl J Med 369:43–53. https://doi.org/10.1056/NEJMoa1302736
Mehine M, Makinen N, Heinonen HR, Aaltonen LA, Vahteristo P (2014) Genomics of uterine leiomyomas: insights from high-throughput sequencing. Fertil Steril 102:621–629. https://doi.org/10.1016/j.fertnstert.2014.06.050
Mentrikoski M, Lastra R, Kurman RJ (2015) Mullerian adenosarcomas with rhabdomyoblastic differentiation are associated with an aggressive clinical course. Mod Pathol 28:298A
Meredith RF, Eisert DR, Kaka Z, Hodgson SE, Johnston GA Jr, Boutselis JG (1986) An excess of uterine sarcomas after pelvic irradiation. Cancer 58:2003–2007
Merino MJ, Torres-Cabala C, Pinto P, Linehan WM (2007) The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Am J Surg Pathol 31:1578–1585. https://doi.org/10.1097/PAS.0b013e31804375b8
Micci F, Walter CU, Teixeira MR, Panagopoulos I, Bjerkehagen B, Saeter G, Heim S (2003) Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). Cancer Genet Cytogenet 144:119–124. S0165460803000256 [pii]
Micci F, Panagopoulos I, Bjerkehagen B, Heim S (2006) Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res 66:107–112. https://doi.org/10.1158/0008-5472.CAN-05-2485. 66/1/107 [pii]
Micci F, Gorunova L, Gatius S, Matias-Guiu X, Davidson B, Heim S, Panagopoulos I (2014) MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma. Cancer Lett 347:75–78. https://doi.org/10.1016/j.canlet.2014.01.030
Micci F et al (2016) Cytogenetic and molecular profile of endometrial stromal sarcoma. Genes Chromosomes Cancer 55:834–846. https://doi.org/10.1002/gcc.22380
Micci F, Brunetti M, Dal Cin P, Nucci MR, Gorunova L, Heim S, Panagopoulos I (2017) Fusion of the genes BRD8 and PHF1 in endometrial stromal sarcoma. Genes Chromosomes Cancer 56:841–845. https://doi.org/10.1002/gcc.22485
Miettinen M, Lasota J (2011) Histopathology of gastrointestinal stromal tumor. J Surg Oncol 104:865–873. https://doi.org/10.1002/jso.21945
Miettinen M, Felisiak-Golabek A, Wasag B, Chmara M, Wang Z, Butzow R, Lasota J (2016) Fumarase-deficient uterine leiomyomas: an immunohistochemical, molecular genetic, and clinicopathologic study of 86 cases. Am J Surg Pathol 40:1661–1669. https://doi.org/10.1097/pas.0000000000000703
Mikami Y, Hata S, Kiyokawa T, Manabe T (2002) Expression of CD10 in malignant mullerian mixed tumors and adenosarcomas: an immunohistochemical study. Mod Pathol 15:923–930. https://doi.org/10.1097/01.MP.0000026058.33869.DB
Miller KN, McClure SP (1992) Papillary adenofibroma of the uterus: report of a case involved by adenocarcinoma and review of the literature. Am J Clin Pathol 97:806–809
Mills AM, Karamchandani JR, Vogel H, Longacre TA (2011) Endocervical fibroblastic malignant peripheral nerve sheath tumor (neurofibrosarcoma): report of a novel entity possibly related to endocervical CD34 fibrocytes. Am J Surg Pathol 35:404–412. https://doi.org/10.1097/PAS.0b013e318208f72e. 00000478-201103000-00011 [pii]
Minassian SS, Frangipane W, Polin JI, Ellis M (1986) Leiomyomatosis peritonealis disseminata. A case report and literature review. J Reprod Med 31:997–1000
Mittal K, Demopoulos RI (2001) MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 32:984–987. https://doi.org/10.1053/hupa.2001.27113
Mittal K, Joutovsky A (2007) Areas with benign morphologic and immunohistochemical features are associated with some uterine leiomyosarcomas. Gynecol Oncol 104:362–365. https://doi.org/10.1016/j.ygyno.2006.08.034
Mittal K, Popiolek D, Demopoulos RI (2000) Uterine myxoid leiomyosarcoma within a leiomyoma. Hum Pathol 31:398–400
Mittal KR et al (2009) Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. Mod Pathol 22:1303–1311. https://doi.org/10.1038/modpathol.2009.96
Moinfar F, Regitnig P, Tabrizi AD, Denk H, Tavassoli FA (2004) Expression of androgen receptors in benign and malignant endometrial stromal neoplasms. Virchows Arch 444:410–414. https://doi.org/10.1007/s00428-004-0981-9
Moinfar F, Azodi M, Tavassoli FA (2007) Uterine sarcomas. Pathology 39:55–71. https://doi.org/10.1080/00313020601136146
Moore M, McCluggage WG (2017) Uterine tumour resembling ovarian sex cord tumour: first report of a large series with follow-up. Histopathology 71:751–759. https://doi.org/10.1111/his.13296
Morice P et al (2003) Prognostic value of initial surgical procedure for patients with uterine sarcoma: analysis of 123 patients. Eur J Gynaecol Oncol 24:237–240
Morotti RA et al (2006) An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children’s Oncology Group experience. Am J Surg Pathol 30:962–968
Mulvany NJ, Slavin JL, Ostor AG, Fortune DW (1994) Intravenous leiomyomatosis of the uterus: a clinicopathologic study of 22 cases. Int J Gynecol Pathol 13:1–9
Mulvany NJ, Ostor AG, Ross I (1995) Diffuse leiomyomatosis of the uterus. Histopathology 27:175–179
Myles JL, Hart WR (1985) Apoplectic leiomyomas of the uterus. A clinicopathologic study of five distinctive hemorrhagic leiomyomas associated with oral contraceptive usage. Am J Surg Pathol 9:798–805
Nakayama H, Teramoto H, Teramoto M (2013) True incidence of uterine adenomatoid tumors. Biomed Rep 1:352–354. https://doi.org/10.3892/br.2013.72
Nasioudis D, Alevizakos M, Chapman-Davis E, Witkin SS, Holcomb K (2017a) Rhabdomyosarcoma of the lower female genital tract: an analysis of 144 cases. Arch Gynecol Obstet 296:327–334. https://doi.org/10.1007/s00404-017-4438-1
Nasioudis D, Kampaktsis PN, Frey M, Witkin SS, Holcomb K (2017b) Primary lymphoma of the female genital tract: an analysis of 697 cases. Gynecol Oncol 145:305–309. https://doi.org/10.1016/j.ygyno.2017.02.043
Navarro D et al (1992) Endometrial stromal sarcoma expression of estrogen receptors, progesterone receptors and estrogen-induced srp27 (24K) suggests hormone responsiveness. J Steroid Biochem Mol Biol 41:589–596
Ng TL et al (2005) Nuclear beta-catenin in mesenchymal tumors. Mod Pathol 18:68–74. https://doi.org/10.1038/modpathol.3800272
Nielsen GP, Oliva E, Young RH, Rosenberg AE, Dickersin GR, Scully RE (1995) Alveolar soft-part sarcoma of the female genital tract: a report of nine cases and review of the literature. Int J Gynecol Pathol 14:283–292
Nogales FF Jr, Matilla A, Carrascal E (1978) Leiomyomatosis peritonealis disseminata. An ultrastructural study. Am J Clin Pathol 69:452–457
Nogales FF et al (1987) Uterine intravascular leiomyomatosis: an update and report of seven cases. Int J Gynecol Pathol 6:331–339
Nogales FF et al (2002) Adenomatoid tumors of the uterus: an analysis of 60 cases. Int J Gynecol Pathol 21:34–40
Nogales FF, Stolnicu S, Harilal KR, Mooney E, Garcia-Galvis OF (2009) Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract. Histopathology 54:471–477. https://doi.org/10.1111/j.1365-2559.2009.03244.x. HIS3244 [pii]
Nola M et al (1996) Prognostic parameters for survival of patients with malignant mesenchymal tumors of the uterus. Cancer 78:2543–2550
Nordal RR, Kristensen GB, Kaern J, Stenwig AE, Pettersen EO, Trope CG (1995) The prognostic significance of stage, tumor size, cellular atypia and DNA ploidy in uterine leiomyosarcoma. Acta Oncol 34:797–802
Nordal RR, Kristensen GB, Kaern J, Stenwig AE, Pettersen EO, Trope CG (1996) The prognostic significance of surgery, tumor size, malignancy grade, menopausal status, and DNA ploidy in endometrial stromal sarcoma. Gynecol Oncol 62:254–259. https://doi.org/10.1006/gyno.1996.0224. S0090-8258(96)90224-3 [pii]
Norris HJ, Parmley T (1975) Mesenchymal tumors of the uterus. V. Intravenous leiomyomatosis. A clinical and pathologic study of 14 cases. Cancer 36:2164–2178
Norris HJ, Taylor HB (1966) Mesenchymal tumors of the uterus. I. A clinical and pathological study of 53 endometrial stromal tumors. Cancer 19:755–766
Norris HJ, Hilliard GD, Irey NS (1988) Hemorrhagic cellular leiomyomas (“apoplectic leiomyoma”) of the uterus associated with pregnancy and oral contraceptives. Int J Gynecol Pathol 7:212–224
Novelli M et al (2010) DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology 57:259–270. https://doi.org/10.1111/j.1365-2559.2010.03624.x. HIS3624 [pii]
Nucci MR (2016) Practical issues related to uterine pathology: endometrial stromal tumors. Mod Pathol 29(Suppl 1):S92–S103. https://doi.org/10.1038/modpathol.2015.140
Nucci MR, O’Connell JT, Huettner PC, Cviko A, Sun D, Quade BJ (2001) h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. Am J Surg Pathol 25:455–463
Nucci MR, Harburger D, Koontz J, Dal Cin P, Sklar J (2007) Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Pathol 31:65–70. https://doi.org/10.1097/01.pas.0000213327.86992.d1. 00000478-200701000-00007 [pii]
Nunez-Alonso C, Battifora HA (1979) Plexiform tumors of the uterus: ultrastructural study. Cancer 44:1707–1714
O’Cearbhaill R, Hensley ML (2010) Optimal management of uterine leiomyosarcoma. Expert Rev Anticancer Ther 10:153–169. https://doi.org/10.1586/era.09.187
O’Connor DM, Norris HJ (1990) Mitotically active leiomyomas of the uterus. Hum Pathol 21:223–227
O’Leary TJ, Steffes MW (1996) Can you count on the mitotic index? Hum Pathol 27:147–151
O’Neill CJ, McBride HA, Connolly LE, McCluggage WG (2007) Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology 50:851–858. https://doi.org/10.1111/j.1365-2559.2007.02699.x
Oduyebo T et al (2014) The value of re-exploration in patients with inadvertently morcellated uterine sarcoma. Gynecol Oncol 132:360–365. https://doi.org/10.1016/j.ygyno.2013.11.024
Ohta Y, Suzuki T, Omatsu M, Hamatani S, Shiokawa A, Kushima M, Ota H (2010) Transition from low-grade endometrial stromal sarcoma to high-grade endometrial stromal sarcoma. Int J Gynecol Pathol 29:374–377. https://doi.org/10.1097/PGP.0b013e3181cef14b. 00004347-201007000-00013 [pii]
Oliva E (2014) Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations. Int J Gynecol Pathol 33:374–384. https://doi.org/10.1097/PGP.0000000000000141
Oliva E (2016) Practical issues in uterine pathology from banal to bewildering: the remarkable spectrum of smooth muscle neoplasia. Mod Pathol 29(Suppl 1):S104–S120. https://doi.org/10.1038/modpathol.2015.139
Oliva E, Young RH, Clement PB, Bhan AK, Scully RE (1995) Cellular benign mesenchymal tumors of the uterus. A comparative morphologic and immunohistochemical analysis of 33 highly cellular leiomyomas and six endometrial stromal nodules, two frequently confused tumors. Am J Surg Pathol 19:757–768
Oliva E, Ferry JA, Young RH, Prat J, Srigley JR, Scully RE (1997) Granulocytic sarcoma of the female genital tract: a clinicopathologic study of 11 cases. Am J Surg Pathol 21:1156–1165
Oliva E, Clement PB, Young RH, Scully RE (1998) Mixed endometrial stromal and smooth muscle tumors of the uterus: a clinicopathologic study of 15 cases. Am J Surg Pathol 22:997–1005
Oliva E, Young RH, Clement PB, Scully RE (1999) Myxoid and fibrous endometrial stromal tumors of the uterus: a report of 10 cases. Int J Gynecol Pathol 18:310–319
Oliva E, Clement PB, Young RH (2000) Endometrial stromal tumors: an update on a group of tumors with a protean phenotype. Adv Anat Pathol 7:257–281
Oliva E, Clement PB, Young RH (2002a) Epithelioid endometrial and endometrioid stromal tumors: a report of four cases emphasizing their distinction from epithelioid smooth muscle tumors and other oxyphilic uterine and extrauterine tumors. Int J Gynecol Pathol 21:48–55
Oliva E, Young RH, Amin MB, Clement PB (2002b) An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol 26:403–412
Oliva EW, Wang WL, Branton P, Logani S, Zannoni GF, Linkov I, Asher M, Soslow RA (2006) Expression of melanocytic (“PEComa”) markers in smooth muscle tumors of the uterus: an immunohistochemcial analyisis of 86 cases. Paper presented at the United States and Canadian Academy of Pathology, Atlanta
Oliva E, de Leval L, Soslow RA, Herens C (2007) High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. Am J Surg Pathol 31:1277–1284. https://doi.org/10.1097/PAS.0b013e318031f012
Oliva E, Carinelli SG, Carcangiu ML (2014) Mesenchymal tumours. Chapter 5, Tumours of the uterine corpus. In: Kurman R, Carcangiu ML, Herrington CS, Young RH (eds) WHO classification of tumours of female reproductive organs. IARC Press, Lyon, pp 135–145
Ordi J, Stamatakos MD, Tavassoli FA (1997) Pure pleomorphic rhabdomyosarcomas of the uterus. Int J Gynecol Pathol 16:369–377
Orii A, Mori A, Zhai YL, Toki T, Nikaido T, Fujii S (1998) Mast cells in smooth muscle tumors of the uterus. Int J Gynecol Pathol 17:336–342
Ouyang DW, Economy KE, Norwitz ER (2006) Obstetric complications of fibroids. Obstet Gynecol Clin N Am 33:153–169. https://doi.org/10.1016/j.ogc.2005.12.010
Panagopoulos I et al (2012) Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma. PLoS One 7:e39354. https://doi.org/10.1371/journal.pone.0039354. PONE-D-12-09483 [pii]
Panagopoulos I et al (2013) Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation. Genes Chromosomes Cancer 52:610–618. https://doi.org/10.1002/gcc.22057
Park SH, Ro JY, Kim HS, Lee ES (2003) Perivascular epithelioid cell tumor of the uterus: immunohistochemical, ultrastructural and molecular study. Pathol Int 53:800–805
Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Nam JH (2008) Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989–2007. J Cancer Res Clin Oncol 134:1277–1287. https://doi.org/10.1007/s00432-008-0422-2
Park JY, Park SK, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH (2011) The impact of tumor morcellation during surgery on the prognosis of patients with apparently early uterine leiomyosarcoma. Gynecol Oncol 122:255–259. https://doi.org/10.1016/j.ygyno.2011.04.021
Park JY, Sung CO, Jang SJ, Song SY, Han JH, Kim KR (2013) Pulmonary metastatic nodules of uterine low-grade endometrial stromal sarcoma: histopathological and immunohistochemical analysis of 10 cases. Histopathology 63:833–840. https://doi.org/10.1111/his.12232
Parker WH, Fu YS, Berek JS (1994) Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol 83:414–418
Parker WH, Kaunitz AM, Pritts EA, Olive DL, Chalas E, Clarke-Pearson DL, Berek JS (2016) U.S. Food and Drug Administration’s guidance regarding morcellation of leiomyomas: well-intentioned, but is it harmful for women? Obstet Gynecol 127:18–22. https://doi.org/10.1097/aog.0000000000001157
Parra-Herran CE, Yuan L, Nucci MR, Quade BJ (2014) Targeted development of specific biomarkers of endometrial stromal cell differentiation using bioinformatics: the IFITM1 model. Mod Pathol 27:569–579. https://doi.org/10.1038/modpathol.2013.123
Parra-Herran C, Quick CM, Howitt BE, Dal Cin P, Quade BJ, Nucci MR (2015) Inflammatory myofibroblastic tumor of the uterus: clinical and pathologic review of 10 cases including a subset with aggressive clinical course. Am J Surg Pathol 39:157–168. https://doi.org/10.1097/pas.0000000000000330
Parra-Herran C, Schoolmeester JK, Yuan L, Dal Cin P, Fletcher CD, Quade BJ, Nucci MR (2016) Myxoid leiomyosarcoma of the uterus: a clinicopathologic analysis of 30 cases and review of the literature with reappraisal of its distinction from other uterine myxoid mesenchymal neoplasms. Am J Surg Pathol 40:285–301. https://doi.org/10.1097/PAS.0000000000000593. 00000478-201603000-00001 [pii]
Patai K, Illyes G, Varbiro S, Gidai J, Kosa L, Vajo Z (2006) Uterine leiomyosarcoma with osteoclast like giant cells and long standing systemic symptoms. Gynecol Oncol 102:403–405. https://doi.org/10.1016/j.ygyno.2006.02.030
Pautier P et al (2000) Analysis of clinicopathologic prognostic factors for 157 uterine sarcomas and evaluation of a grading score validated for soft tissue sarcoma. Cancer 88:1425–1431
Pauwels P, Dal Cin P, Van de Moosdijk CN, Vrints L, Sciot R, Van den Berghe H (1996) Cytogenetics revealing the diagnosis in a metastatic endometrial stromal sarcoma. Histopathology 29:84–87
Payson M, Leppert P, Segars J (2006) Epidemiology of myomas. Obstet Gynecol Clin N Am 33:1–11. https://doi.org/10.1016/j.ogc.2005.12.004
Pedeutour F, Quade BJ, Sornberger K, Tallini G, Ligon AH, Weremowicz S, Morton CC (2000) Dysregulation of HMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14. Genes Chromosomes Cancer 27:209–215
Pelmus M et al (2009) Prognostic factors in early-stage leiomyosarcoma of the uterus. Int J Gynecol Cancer 19:385–390. https://doi.org/10.1111/IGC.0b013e3181a1bfbc
Pérot G et al (2012) MED12 alterations in both human benign and malignant uterine soft tissue tumors. PLoS One 7:e40015. https://doi.org/10.1371/journal.pone.0040015
Perrone T, Dehner LP (1988) Prognostically favorable “mitotically active” smooth-muscle tumors of the uterus. A clinicopathologic study of ten cases. Am J Surg Pathol 12:1–8
Peters WA 3rd, Howard DR, Andersen WA, Figge DC (1994) Uterine smooth-muscle tumors of uncertain malignant potential. Obstet Gynecol 83:1015–1020
Pickett JL et al (2017) Inflammatory myofibroblastic tumors of the female genital tract are under-recognized: a low threshold for ALK immunohistochemistry is required. Am J Surg Pathol 41:1433–1442. https://doi.org/10.1097/pas.0000000000000909
Pieslor PC, Orenstein JM, Hogan DL, Breslow A (1979) Ultrastructure of myofibroblasts and decidualized cells in leiomyomatosis peritonealis disseminata. Am J Clin Pathol 72:875–882
Pinto A, Kahn RM, Rosenberg AE, Slomovitz B, Quick CM, Whisman MK, Huang M (2018) Uterine rhabdomyosarcoma in adults. Hum Pathol. https://doi.org/10.1016/j.humpath.2018.01.007
Piscuoglio S et al (2016) Uterine adenosarcomas are mesenchymal neoplasms. J Pathol 238:381–388. https://doi.org/10.1002/path.4675
Portugal R, Oliva E (2009) Calretinin: diagnostic utility in the female genital tract. Adv Anat Pathol 16:118–124. https://doi.org/10.1097/PAP.0b013e31819923ce. 00125480-200903000-00005 [pii]
Pounder DJ (1982) Fatty tumours of the uterus. J Clin Pathol 35:1380–1383
Pradhan D, Mohanty SK (2013) Uterine tumors resembling ovarian sex cord tumors. Arch Pathol Lab Med 137:1832–1836. https://doi.org/10.5858/arpa.2012-0634-RS
Prat J (2009) FIGO staging for uterine sarcomas. Int J Gynaecol Obstet 104:177–178. https://doi.org/10.1016/j.ijgo.2008.12.008
Prat J, Mbatani (2015) Uterine sarcomas. Int J Gynaecol Obstet 131(Suppl 2):S105–S110. https://doi.org/10.1016/j.ijgo.2015.06.006. S0020-7292(15)00377-X [pii]
Prayson RA, Hart WR (1992) Mitotically active leiomyomas of the uterus. Am J Clin Pathol 97:14–20
Prayson RA, Goldblum JR, Hart WR (1997) Epithelioid smooth-muscle tumors of the uterus: a clinicopathologic study of 18 patients. Am J Surg Pathol 21:383–391
Press MF, Scully RE (1985) Endometrial “sarcomas” complicating ovarian thecoma, polycystic ovarian disease and estrogen therapy. Gynecol Oncol 21:135–154. 0090-8258(85)90246-X [pii]
Pugh A, McCluggage WG, Hirschowitz L (2012) Multifocal uterine myxoid change: a newly recognized association with neurofibromatosis type 1. Int J Gynecol Pathol 31:580–583. https://doi.org/10.1097/PGP.0b013e31824d359a
Punnett HH, Halligan GE, Zaeri N, Karmazin N (1989) Translocation 10;17 in clear cell sarcoma of the kidney. A first report. Cancer Genet Cytogenet 41:123–128. 0165-4608(89)90116-7 [pii]
Quade BJ (1995) Pathology, cytogenetics and molecular biology of uterine leiomyomas and other smooth muscle lesions. Curr Opin Obstet Gynecol 7:35–42
Quade BJ, McLachlin CM, Soto-Wright V, Zuckerman J, Mutter GL, Morton CC (1997) Disseminated peritoneal leiomyomatosis. Clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation. Am J Pathol 150:2153–2166
Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC (2002) Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case. Mod Pathol 15:351–356. https://doi.org/10.1038/modpathol.3880529
Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC (2003) Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. Cancer Res 63:1351–1358
Quddus MR, Rashid L, Sung CJ, Steinhoff MM, Cunxian Z, Lawrence WD (2009) Ewing’s sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas. Reprod Sci 16:591–595. https://doi.org/10.1177/1933719109332824
Rabban JT, Zaloudek CJ, Shekitka KM, Tavassoli FA (2005) Inflammatory myofibroblastic tumor of the uterus: a clinicopathologic study of 6 cases emphasizing distinction from aggressive mesenchymal tumors. Am J Surg Pathol 29:1348–1355
Rackow BW, Arici A (2006) Options for medical treatment of myomas. Obstet Gynecol Clin N Am 33:97–113. https://doi.org/10.1016/j.ogc.2005.12.014
Radig K, Buhtz P, Roessner A (1998) Alveolar soft part sarcoma of the uterine corpus. Report of two cases and review of the literature. Pathol Res Pract 194:59–63
Rahimi S, Akaev I, Marani C, Chopra M, Yeoh CC (2018) Immunohistochemical expression of different subtypes of cytokeratins by endometrial stromal sarcoma. Appl Immunohistochem Mol Morphol. https://doi.org/10.1097/PAI.0000000000000642
Rakheja D, Weinberg AG, Tomlinson GE, Partridge K, Schneider NR (2004) Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. Cancer Genet Cytogenet 154:175–179. https://doi.org/10.1016/j.cancergencyto.2004.02.024. S0165-4608(04)00111-6 [pii]
Ramalingam P, Masand RP, Euscher ED, Malpica A (2016) Undifferentiated carcinoma of the endometrium: an expanded immunohistochemical analysis including PAX-8 and basal-like carcinoma surrogate markers. Int J Gynecol Pathol 35:410–418. https://doi.org/10.1097/PGP.0000000000000248
Rao Q et al (2013) Cathepsin K expression in a wide spectrum of perivascular epithelioid cell neoplasms (PEComas): a clinicopathological study emphasizing extrarenal PEComas. Histopathology 62:642–650. https://doi.org/10.1111/his.12059
Raut CP et al (2009) Predictive value of FIGO and AJCC staging systems in patients with uterine leiomyosarcoma. Eur J Cancer 45:2818–2824. https://doi.org/10.1016/j.ejca.2009.06.030
Ravid Y, Formanski M, Smith Y, Reich R, Davidson B (2016) Uterine leiomyosarcoma and endometrial stromal sarcoma have unique miRNA signatures. Gynecol Oncol 140:512–517. https://doi.org/10.1016/j.ygyno.2016.01.001
Reed NS et al (2008) Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874). Eur J Cancer 44:808–818. https://doi.org/10.1016/j.ejca.2008.01.019
Regidor PA, Schmidt M, Callies R, Kato K, Schindler AE (1995) Estrogen and progesterone receptor content of GnRH analogue pretreated and untreated uterine leiomyomata. Eur J Obstet Gynecol Reprod Biol 63:69–73
Reich O, Regauer S (2004) Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical study. Mod Pathol 17:104–108. https://doi.org/10.1038/sj.modpathol.3800031
Reich O, Regauer S (2007) Hormonal therapy of endometrial stromal sarcoma. Curr Opin Oncol 19:347–352. https://doi.org/10.1097/CCO.0b013e3281a7ef3a. 00001622-200707000-00011 [pii]
Reich O, Regauer S, Urdl W, Lahousen M, Winter R (2000) Expression of oestrogen and progesterone receptors in low-grade endometrial stromal sarcomas. Br J Cancer 82:1030–1034. https://doi.org/10.1054/bjoc.1999.1038. S0007092099910388 [pii]
Reyes C, Karamurzin Y, Frizzell N, Garg K, Nonaka D, Chen YB, Soslow RA (2014) Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry. Mod Pathol 27:1020–1027. https://doi.org/10.1038/modpathol.2013.215
Rivasi F, Botticelli L, Bettelli SR, Masellis G (2008) Alveolar rhabdomyosarcoma of the uterine cervix. A case report confirmed by FKHR break-apart rearrangement using a fluorescence in situ hybridization probe on paraffin-embedded tissues. Int J Gynecol Pathol 27:442–446
Rizeq MN, van de Rijn M, Hendrickson MR, Rouse RV (1994) A comparative immunohistochemical study of uterine smooth muscle neoplasms with emphasis on the epithelioid variant. Hum Pathol 25:671–677
Roma AA, Yang B, Senior ME, Goldblum JR (2005) TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report. Int J Gynecol Pathol 24:131–135
Roma AA, Allende D, Fadare O, Forscher C, Rutgers JK (2017) On uterine angiosarcomas: 2 additional cases. Int J Gynecol Pathol 36:369–371. https://doi.org/10.1097/pgp.0000000000000352
Ronaghy A, Xiao GQ, Santagada E, Hasanovic A, Unger P (2018) Expression of GATA-3 in testicular and gynecologic mesothelial neoplastic and non-neoplastic tissues. Int J Gynecol Pathol 37:284–289. https://doi.org/10.1097/pgp.0000000000000403
Rose PG, Piver MS, Tsukada Y, Lau T (1989) Patterns of metastasis in uterine sarcoma. An autopsy study. Cancer 63:935–938
Rosty C, Genestie C, Blondon J, Le Charpentier Y (1998) Endometrial stromal tumor associated with rhabdoid phenotype and and zones of “sex cord-like” differentiation. Ann Pathol 18:133–136. MDOI-AP-07-1998-18-2-0242-6498-101019-ART57 [pii]
Roth LM, Reed RJ (1999) Dissecting leiomyomas of the uterus other than cotyledonoid dissecting leiomyomas: a report of eight cases. Am J Surg Pathol 23:1032–1039
Roth LM, Reed RJ (2000) Cotyledonoid leiomyoma of the uterus: report of a case. Int J Gynecol Pathol 19:272–275
Roth E, Taylor HB (1966) Heterotopic cartilage in the uterus. Obstet Gynecol 27:838–844
Roth LM, Reed RJ, Sternberg WH (1996) Cotyledonoid dissecting leiomyoma of the uterus. The Sternberg tumor. Am J Surg Pathol 20:1455–1461
Roy M et al (2017) Androgen receptor expression in endometrial stromal sarcoma: correlation with clinicopathologic features. Int J Gynecol Pathol 36:420–427. https://doi.org/10.1097/PGP.0000000000000353
Rush DS, Tan J, Baergen RN, Soslow RA (2001) h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma. Am J Surg Pathol 25:253–258
Rushing RS et al (2003) Uterine sarcomas express KIT protein but lack mutation(s) in exon 11 or 17 of c-KIT. Gynecol Oncol 91:9–14
Sahin AA, Silva EG, Landon G, Ordonez NG, Gershenson DM (1989) Endometrial tissue in myometrial vessels not associated with menstruation. Int J Gynecol Pathol 8:139–146
Sangoi AR, McKenney JK, Schwartz EJ, Rouse RV, Longacre TA (2009) Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. Mod Pathol 22:1228–1235. https://doi.org/10.1038/modpathol.2009.90
Sanz-Ortega J, Vocke C, Stratton P, Linehan WM, Merino MJ (2013) Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome. Am J Surg Pathol 37:74–80. https://doi.org/10.1097/PAS.0b013e31825ec16f
Satoh Y, Ishikawa Y, Miyoshi T, Mukai H, Okumura S, Nakagawa K (2003) Pulmonary metastases from a low-grade endometrial stromal sarcoma confirmed by chromosome aberration and fluorescence in-situ hybridization approaches: a case of recurrence 13 years after hysterectomy. Virchows Arch 442:173–178. https://doi.org/10.1007/s00428-002-0731-9
Schaefer IM, Hornick JL, Sholl LM, Quade BJ, Nucci MR, Parra-Herran C (2017) Abnormal p53 and p16 staining patterns distinguish uterine leiomyosarcoma from inflammatory myofibroblastic tumour. Histopathology 70:1138–1146. https://doi.org/10.1111/his.13176
Schammel DP, Tavassoli FA (1998) Uterine angiosarcomas: a morphologic and immunohistochemical study of four cases. Am J Surg Pathol 22:246–250
Schammel DP, Silver SA, Tavassoli FA (1999) Combined endometrial stromal/smooth muscle neoplasms of the uterus. A clinicopathologic study of 38 cases [abstract]. Mod Pathol 12:124A
Schmid C, Beham A, Kratochvil P (1990) Haematopoiesis in a degenerating uterine leiomyoma. Arch Gynecol Obstet 248:81–86
Schneider D, Halperin R, Segal M, Maymon R, Bukovsky I (1995) Myxoid leiomyosarcoma of the uterus with unusual malignant histologic pattern – a case report. Gynecol Oncol 59:156–158. https://doi.org/10.1006/gyno.1995.1284
Schoenmakers EF, Huysmans C, Van de Ven WJ (1999) Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. Cancer Res 59:19–23
Schoenmakers EF et al (2013) Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma. Genes Chromosomes Cancer 52:11–23. https://doi.org/10.1002/gcc.22001
Schoolmeester JK, Park KJ (2015) Incidental nodal lymphangioleiomyomatosis is not a harbinger of pulmonary lymphangioleiomyomatosis: a study of 19 cases with evaluation of diagnostic immunohistochemistry. Am J Surg Pathol 39:1404–1410. https://doi.org/10.1097/pas.0000000000000470
Schoolmeester JK, Howitt BE, Hirsch MS, Dal Cin P, Quade BJ, Nucci MR (2014) Perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: clinicopathologic and immunohistochemical characterization of 16 cases. Am J Surg Pathol 38:176–188. https://doi.org/10.1097/pas.0000000000000133
Schoolmeester JK et al (2015) TFE3 translocation-associated perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: morphology, immunophenotype, differential diagnosis. Am J Surg Pathol 39:394–404. https://doi.org/10.1097/pas.0000000000000349
Schoolmeester JK, Stamatakos MD, Moyer AM, Park KJ, Fairbairn M, Fader AN (2016) Pleomorphic Liposarcoma arising in a lipoleiomyosarcoma of the uterus: report of a case with genetic profiling by a next generation sequencing panel. Int J Gynecol Pathol 35:321–326. https://doi.org/10.1097/pgp.0000000000000241
Schoolmeester JK, Carlson J, Keeney GL, Fritchie KJ, Oliva E, Young RH, Nucci MR (2017) Alveolar soft part sarcoma of the female genital tract: a morphologic, immunohistochemical, and molecular cytogenetic study of 10 cases with emphasis on its distinction from morphologic mimics. Am J Surg Pathol 41:622–632. https://doi.org/10.1097/pas.0000000000000796
Schwartz PE, Kelly MG (2006) Malignant transformation of myomas: myth or reality? Obstet Gynecol Clin N Am 33:183–198, xii. https://doi.org/10.1016/j.ogc.2005.12.003
Schwartz LB, Diamond MP, Schwartz PE (1993) Leiomyosarcomas: clinical presentation. Am J Obstet Gynecol 168:180–183
Sciallis AP, Bedroske PP, Schoolmeester JK, Sukov WR, Keeney GL, Hodge JC, Bell DA (2014) High-grade endometrial stromal sarcomas: a clinicopathologic study of a group of tumors with heterogenous morphologic and genetic features. Am J Surg Pathol 38:1161–1172. https://doi.org/10.1097/PAS.0000000000000256. 00000478-201409000-00001 [pii]
Seidman JD, Thomas RM (1993) Multiple plexiform tumorlets of the uterus. Arch Pathol Lab Med 117:1255–1256
Seidman MA, Oduyebo T, Muto MG, Crum CP, Nucci MR, Quade BJ (2012) Peritoneal dissemination complicating morcellation of uterine mesenchymal neoplasms. PLoS One 7:e50058. https://doi.org/10.1371/journal.pone.0050058
Sener AB, Seckin NC, Ozmen S, Gokmen O, Dogu N, Ekici E (1996) The effects of hormone replacement therapy on uterine fibroids in postmenopausal women. Fertil Steril 65:354–357
Shah R, McCluggage WG (2009) Symplastic atypia in neoplastic and non-neoplastic endometrial stroma: report of 3 cases with a review of atypical symplastic cells within the female genital tract. Int J Gynecol Pathol 28:334–337. https://doi.org/10.1097/PGP.0b013e3181999450
Shah VI, McCluggage WG (2015) Cyclin D1 does not distinguish YWHAE-NUTM2 high-grade endometrial stromal sarcoma from undifferentiated endometrial carcinoma. Am J Surg Pathol 39:722–724. https://doi.org/10.1097/PAS.0000000000000427. 00000478-201505000-00019 [pii]
Shah JP, Bryant CS, Kumar S, Ali-Fehmi R, Malone JM Jr, Morris RT (2008) Lymphadenectomy and ovarian preservation in low-grade endometrial stromal sarcoma. Obstet Gynecol 112:1102–1108. https://doi.org/10.1097/AOG.0b013e31818aa89a. 112/5/1102 [pii]
Shaw RW (1998) Gonadotrophin hormone-releasing hormone analogue treatment of fibroids. Baillieres Clin Obstet Gynaecol 12:245–268
Signorelli M, Fruscio R, Dell’Anna T, Buda A, Giuliani D, Ceppi L, Milani R (2010) Lymphadenectomy in uterine low-grade endometrial stromal sarcoma: an analysis of 19 cases and a literature review. Int J Gynecol Cancer 20:1363–1366. https://doi.org/10.1111/IGC.0b013e3181efd861. 00009577-201011000-00015 [pii]
Silva EG, Tornos C, Ordonez NG, Morris M (1995) Uterine leiomyosarcoma with clear cell areas. Int J Gynecol Pathol 14:174–178
Silva EG, Deavers MT, Bodurka DC, Malpica A (2004) Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. Am J Surg Pathol 28:244–249
Silva EG, Bodurka DC, Scouros MA, Ayala A (2005) A uterine leiomyosarcoma that became positive for HMB45 in the metastasis. Ann Diagn Pathol 9:43–45
Simpson KW, Albores-Saavedra J (2007) HMB-45 reactivity in conventional uterine leiomyosarcomas. Am J Surg Pathol 31:95–98. https://doi.org/10.1097/01.pas.0000213346.57391.70
Sinkre P, Albores-Saavedra J, Miller DS, Copeland LJ, Hameed A (2000a) Endometrial endometrioid carcinomas associated with Ewing sarcoma/peripheral primitive neuroectodermal tumor. Int J Gynecol Pathol 19:127–132
Sinkre P, Miller DS, Milchgrub S, Hameed A (2000b) Adenomyofibroma of the endometrium with skeletal muscle differentiation. Int J Gynecol Pathol 19:280–283
Siskin GP et al (2006) A prospective multicenter comparative study between myomectomy and uterine artery embolization with polyvinyl alcohol microspheres: long-term clinical outcomes in patients with symptomatic uterine fibroids. J Vasc Interv Radiol 17:1287–1295. https://doi.org/10.1097/01.rvi.0000231953.91787.af
Slatter TL et al (2015) Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. J Pathol Clin Res 1:95–105. https://doi.org/10.1002/cjp2.11
Sorensen PHB et al (2002) PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the Children’s Oncology Group. J Clin Oncol 20:2672–2679
Sornberger KS et al (1999) Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6. Cancer Genet Cytogenet 114:9–16
Soslow RA, Ali A, Oliva E (2008) Mullerian adenosarcomas: an immunophenotypic analysis of 35 cases. Am J Surg Pathol 32:1013–1021
Sozen I, Arici A (2006) Cellular biology of myomas: interaction of sex steroids with cytokines and growth factors. Obstet Gynecol Clin N Am 33:41–58. https://doi.org/10.1016/j.ogc.2005.12.005
Spies JB, Ascher SA, Roth AR, Kim J, Levy EB, Gomez-Jorge J (2001) Uterine artery embolization for leiomyomata. Obstet Gynecol 98:29–34
Staats PN et al (2009) Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors. Am J Surg Pathol 33:1206–1212. https://doi.org/10.1097/PAS.1200b1013e3181a1207b1209cf
Stemme S, Ghaderi M, Carlson JW (2014) Diagnosis of endometrial stromal tumors: a clinicopathologic study of 25 biopsy specimens with identification of problematic areas. Am J Clin Pathol 141:133–139. https://doi.org/10.1309/AJCPXD0TPYSNVI8I. 141/1/133 [pii]
Stewart L et al (2008) Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancer. Arch Dermatol 144:1584–1592. https://doi.org/10.1001/archdermatol.2008.517
Stewart CJ, Leung YC, Murch A, Peverall J (2014) Evaluation of fluorescence in-situ hybridization in monomorphic endometrial stromal neoplasms and their histological mimics: a review of 49 cases. Histopathology 65:473–482. https://doi.org/10.1111/his.12406
Stewart CJ, Charles A, Foulkes WD (2016a) Gynecologic manifestations of the DICER1 syndrome. Surg Pathol Clin 9:227–241. https://doi.org/10.1016/j.path.2016.01.002
Stewart CJ, Crook M, Tan A (2016b) SF1 immunohistochemistry is useful in differentiating uterine tumours resembling sex cord-stromal tumours from potential histological mimics. Pathology 48:434–440. https://doi.org/10.1016/j.pathol.2016.03.013
Stolnicu S, Molnar C, Barsan I, Boros M, Nogales FF, Soslow RA (2016) The impact on survival of an extensive sex cord-like component in mullerian adenosarcomas: a study comprising 6 cases. Int J Gynecol Pathol 35:147–152. https://doi.org/10.1097/pgp.0000000000000231
Stovall TG, Ling FW, Henry LC, Woodruff MR (1991) A randomized trial evaluating leuprolide acetate before hysterectomy as treatment for leiomyomas. Am J Obstet Gynecol 164:1420–1423; discussion 1423-1425
Subbiah V et al (2015) STUMP un “stumped”: anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusion. J Hematol Oncol 8:66. https://doi.org/10.1186/s13045-015-0160-2
Suginami H, Kaura R, Ochi H, Matsuura S (1990) Intravenous leiomyomatosis with cardiac extension: successful surgical management and histopathologic study. Obstet Gynecol 76:527–529
Sullivan LM, Atkins KA, LeGallo RD (2009) PAX immunoreactivity identifies alveolar rhabdomyosarcoma. Am J Surg Pathol 33:775–780. https://doi.org/10.1097/PAS.0b013e318191614f
Sumathi VP, Al-Hussaini M, Connolly LE, Fullerton L, McCluggage WG (2004) Endometrial stromal neoplasms are immunoreactive with WT-1 antibody. Int J Gynecol Pathol 23:241–247. 00004347-200407000-00007 [pii]
Sutton G, Blessing J, Hanjani P, Kramer P (2005) Phase II evaluation of liposomal doxorubicin (Doxil) in recurrent or advanced leiomyosarcoma of the uterus: a Gynecologic Oncology Group study. Gynecol Oncol 96:749–752. https://doi.org/10.1016/j.ygyno.2004.11.036
Tahlan A, Nanda A, Mohan H (2006) Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature. Int J Gynecol Pathol 25:361–365
Tai LH, Tavassoli FA (2002) Endometrial polyps with atypical (bizarre) stromal cells. Am J Surg Pathol 26:505–509
Tanimoto A, Sasaguri T, Arima N, Hashimoto H, Hamada T, Sasaguri Y (1996) Endometrial stromal sarcoma of the uterus with rhabdoid features. Pathol Int 46:231–237
Tanner EJ, Garg K, Leitao MM Jr, Soslow RA, Hensley ML (2012) High grade undifferentiated uterine sarcoma: surgery, treatment, and survival outcomes. Gynecol Oncol 127:27–31. https://doi.org/10.1016/j.ygyno.2012.06.030. S0090-8258(12)00481-7 [pii]
Tanner EJ, Toussaint T, Leitao MM Jr, Hensley ML, Soslow RA, Gardner GJ, Jewell EL (2013) Management of uterine adenosarcomas with and without sarcomatous overgrowth. Gynecol Oncol 129:140–144. https://doi.org/10.1016/j.ygyno.2012.12.036
Tavassoli FA, Norris HJ (1981) Mesenchymal tumours of the uterus. VII. A clinicopathological study of 60 endometrial stromal nodules. Histopathology 5:1–10
Tavassoli FA, Norris HJ (1982) Peritoneal leiomyomatosis (leiomyomatosis peritonealis disseminata): a clinicopathologic study of 20 cases with ultrastructural observations. Int J Gynecol Pathol 1:59–74
Tawfik O, Rao D, Nothnick WB, Graham A, Mau B, Fan F (2014) Transgelin, a novel marker of smooth muscle differentiation, effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. Int J Gynecol Obstet Reprod Med Res 1:26–31
Terada T (2009) Gastrointestinal stromal tumor of the uterus: a case report with genetic analyses of c-kit and PDGFRA genes. Int J Gynecol Pathol 28:29–34. https://doi.org/10.1097/PGP.0b013e3181808000
Thway K, Fisher C (2015) PEComa: morphology and genetics of a complex tumor family. Ann Diagn Pathol 19:359–368. https://doi.org/10.1016/j.anndiagpath.2015.06.003
Tietze L, Gunther K, Horbe A, Pawlik C, Klosterhalfen B, Handt S, Merkelbach-Bruse S (2000) Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. Hum Pathol 31:126–128
Tiltman AJ (1985) The effect of progestins on the mitotic activity of uterine fibromyomas. Int J Gynecol Pathol 4:89–96
Toki T, Shimizu M, Takagi Y, Ashida T, Konishi I (2002) CD10 is a marker for normal and neoplastic endometrial stromal cells. Int J Gynecol Pathol 21:41–47
Tomlinson IP et al (2002) Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30:406–410. https://doi.org/10.1038/ng849
Toro JR et al (2003) Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. Am J Hum Genet 73:95–106. https://doi.org/10.1086/376435
Torres VE et al (1995) Extrapulmonary lymphangioleiomyomatosis and lymphangiomatous cysts in tuberous sclerosis complex. Mayo Clin Proc 70:641–648. https://doi.org/10.1016/s0025-6196(11)63915-3
Tresukosol D, Kudelka AP, Malpica A, Varma DG, Edwards CL, Kavanagh JJ (1995) Leuprolide acetate and intravascular leiomyomatosis. Obstet Gynecol 86:688–692
Tulandi T, Leung A, Jan N (2016) Nonmalignant sequelae of unconfined morcellation at laparoscopic hysterectomy or myomectomy. J Minim Invasive Gynecol 23:331–337. https://doi.org/10.1016/j.jmig.2016.01.017
Ubago JM, Zhang Q, Kim JJ, Kong B, Wei JJ (2016) Two subtypes of atypical leiomyoma: clinical, histologic, and molecular analysis. Am J Surg Pathol 40:923–933. https://doi.org/10.1097/pas.0000000000000646
Upadhyaya NB, Doody MC, Googe PB (1990) Histopathological changes in leiomyomata treated with leuprolide acetate. Fertil Steril 54:811–814
van Diest PJ et al (1992) Reproducibility of mitosis counting in 2,469 breast cancer specimens: results from the Multicenter Morphometric Mammary Carcinoma Project. Hum Pathol 23:603–607
van Slegtenhorst M et al (1997) Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805–808
Vang R, Kempson RL (2002) Perivascular epithelioid cell tumor (‘PEComa’) of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors. Am J Surg Pathol 26:1–13
Vang R, Medeiros LJ, Ha CS, Deavers M (2000) Non-Hodgkin’s lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol 13:19–28. https://doi.org/10.1038/modpathol.3880005
Varghese L, Arnesen M, Boente M (2006) Primitive neuroectodermal tumor of the uterus: a case report and review of literature. Int J Gynecol Pathol 25:373–377
Venkatraman L, Elliott H, Steele EK, McClelland HR, McCluggage WG (2003) Serous carcinoma arising in an adenofibroma of the endometrium. Int J Gynecol Pathol 22:194–197
Veras E, Malpica A, Deavers MT, Silva EG (2009) Mitosis-specific marker phospho-histone H3 in the assessment of mitotic index in uterine smooth muscle tumors: a pilot study. Int J Gynecol Pathol 28:316–321. https://doi.org/10.1097/PGP.0b013e318193df97
Veras E, Zivanovic O, Jacks L, Chiappetta D, Hensley M, Soslow R (2011) “Low-grade leiomyosarcoma” and late-recurring smooth muscle tumors of the uterus: a heterogenous collection of frequently misdiagnosed tumors associated with an overall favorable prognosis relative to conventional uterine leiomyosarcomas. Am J Surg Pathol 35:1626–1637. https://doi.org/10.1097/PAS.0b013e31822b44d2
Vitiello D, McCarthy S (2006) Diagnostic imaging of myomas. Obstet Gynecol Clin N Am 33:85–95. https://doi.org/10.1016/j.ogc.2005.12.013
Viville B, Charnock-Jones DS, Sharkey AM, Wetzka B, Smith SK (1997) Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium. Hum Reprod 12:815–822
Vollenhoven B (1998) 1 Introduction: the epidemiology of uterine leiomyomas. Baillieres Clin Obstet Gynaecol 12:169–176. https://doi.org/10.1016/S0950-3552(98)80059-X
Wachter DL, Wunsch PH, Hartmann A, Agaimy A (2011) Adenomatoid tumors of the female and male genital tract. A comparative clinicopathologic and immunohistochemical analysis of 47 cases emphasizing their site-specific morphologic diversity. Virchows Arch 458:593–602. https://doi.org/10.1007/s00428-011-1054-5
Wagner AJ et al (2010) Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. J Clin Oncol 28:835–840. https://doi.org/10.1200/jco.2009.25.2981
Wallach EE, Vlahos NF (2004) Uterine myomas: an overview of development, clinical features, and management. Obstet Gynecol 104:393–406. https://doi.org/10.1097/01.aog.0000136079.62513.39
Wang X, Kumar D, Seidman JD (2006) Uterine lipoleiomyomas: a clinicopathologic study of 50 cases. Int J Gynecol Pathol 25:239–242. https://doi.org/10.1097/01.pgp.0000192273.66931.29
Wang WL et al (2011) Histopathologic prognostic factors in stage I leiomyosarcoma of the uterus: a detailed analysis of 27 cases. Am J Surg Pathol 35:522–529. https://doi.org/10.1097/PAS.0b013e31820ca624
Wang W, Zhu H, Wang J, Wang S, Wang D, Zhao J, Zhu H (2016) Clonality assessment of adenomatoid tumor supports its neoplastic nature. Hum Pathol 48:88–94. https://doi.org/10.1016/j.humpath.2015.09.032
Warburg O (1956) On the origin of cancer cells. Science 123:309–314
Watanabe K, Suzuki T (2006) Uterine leiomyoma versus leiomyosarcoma: a new attempt at differential diagnosis based on their cellular characteristics. Histopathology 48:563–568. https://doi.org/10.1111/j.1365-2559.2006.02368.x
Wei MH et al (2006) Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet 43:18–27. https://doi.org/10.1136/jmg.2005.033506
Weichert W, Denkert C, Gauruder-Burmester A, Kurzeja R, Hamm B, Dietel M, Kroencke TJ (2005) Uterine arterial embolization with tris-acryl gelatin microspheres: a histopathologic evaluation. Am J Surg Pathol 29:955–961
Weissman A, Talmon R, Jakobi P (1993) Cavernous hemangioma of the uterus in a pregnant woman. Obstet Gynecol 81:825–827
Wolff M, Silva F, Kaye G (1979) Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms. Report of nine cases, including three males. Am J Surg Pathol 3:325–342
Wolfson AH et al (1994) A multivariate analysis of clinicopathologic factors for predicting outcome in uterine sarcomas. Gynecol Oncol 52:56–62
Wu TI et al (2013) Clinicopathologic parameters and immunohistochemical study of endometrial stromal sarcomas. Int J Gynecol Pathol 32:482–492. https://doi.org/10.1097/PGP.0b013e3182729131
Xue WC, Cheung AN (2011) Endometrial stromal sarcoma of uterus. Best Pract Res Clin Obstet Gynaecol 25:719–732. https://doi.org/10.1016/j.bpobgyn.2011.07.004. S1521-6934(11)00108-8 [pii]
Yamadori I, Kobayashi S, Ogino T, Ohmori M, Tanaka H, Jimbo T (1993) Uterine leiomyoma with a focus of fatty and cartilaginous differentiation. Acta Obstet Gynecol Scand 72:307–309
Yang EJ, Mutter GL (2015) Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. Mod Pathol 28:830–835. https://doi.org/10.1038/modpathol.2015.35
Yang Y et al (2012) A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer. Cancer Genet 205:377–390. https://doi.org/10.1016/j.cancergen.2012.05.001
Yang CY et al (2015) Targeted next-generation sequencing of cancer genes identified frequent TP53 and ATRX mutations in leiomyosarcoma. Am J Transl Res 7:2072–2081
Yang EJ, Howitt BE, Fletcher CD, Nucci MR (2017) Solitary fibrous tumor of the female genital tract: a clinicopathologic analysis of 25 cases. Histopathology. https://doi.org/10.1111/his.13430
Yang EJ, Howitt BE, Fletcher CDM, Nucci MR (2018) Solitary fibrous tumour of the female genital tract: a clinicopathological analysis of 25 cases. Histopathology 72:749–759. https://doi.org/10.1111/his.13430
Yilmaz A, Rush DS, Soslow RA (2002) Endometrial stromal sarcomas with unusual histologic features: a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation. Am J Surg Pathol 26:1142–1150
Yoon A et al (2014) Prognostic factors and outcomes in endometrial stromal sarcoma with the 2009 FIGO staging system: a multicenter review of 114 cases. Gynecol Oncol 132:70–75. https://doi.org/10.1016/j.ygyno.2013.10.029
Young RH, Scully RE (1990) Sarcomas metastatic to the ovary: a report of 21 cases. Int J Gynecol Pathol 9:231–252
Young RH, Prat J, Scully RE (1984) Endometrioid stromal sarcomas of the ovary. A clinicopathologic analysis of 23 cases. Cancer 53:1143–1155
Young RH, Harris NL, Scully RE (1985) Lymphoma-like lesions of the lower female genital tract: a report of 16 cases. Int J Gynecol Pathol 4:289–299
Zaloudek CJ, Norris HJ (1981) Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. Cancer 48:354–366
Zamecnik M, Michal M (1998) Endometrial stromal nodule with retiform sex-cord-like differentiation. Pathol Res Pract 194:449–453
Zhai YL, Kobayashi Y, Mori A, Orii A, Nikaido T, Konishi I, Fujii S (1999) Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas. Int J Gynecol Pathol 18:20–28
Zhang H, Luo J, Feng X (2012) Kaposiform hemangioendothelioma in the uterine cervix of a 5-year girl. Fetal Pediatr Pathol 31:273–277. https://doi.org/10.3109/15513815.2012.659382
Zhang Q et al (2014) Molecular analyses of 6 different types of uterine smooth muscle tumors: emphasis in atypical leiomyoma. Cancer 120:3165–3177. https://doi.org/10.1002/cncr.28900
Zhang Q et al (2017) Fumarate hydratase mutations and alterations in leiomyoma with bizarre nuclei. Int J Gynecol Pathol. https://doi.org/10.1097/pgp.0000000000000447
Zivanovic O et al (2009) Stage-specific outcomes of patients with uterine leiomyosarcoma: a comparison of the International Federation of Gynecology and Obstetrics and American Joint Committee on Cancer staging systems. J Clin Oncol 27:2066–2072. https://doi.org/10.1200/jco.2008.19.8366
Zivanovic O et al (2012) A nomogram to predict postresection 5-year overall survival for patients with uterine leiomyosarcoma. Cancer 118:660–669. https://doi.org/10.1002/cncr.26333
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Oliva, E., Zaloudek, C.J., Soslow, R.A. (2018). Mesenchymal Tumors of the Uterus. In: Kurman, R., Hedrick Ellenson, L., Ronnett, B. (eds) Blaustein's Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3165-7_10-2
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DOI: https://doi.org/10.1007/978-1-4614-3165-7_10-2
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Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-3165-7
Online ISBN: 978-1-4614-3165-7
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