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Somatosensation: End Organs for Tactile Sensation

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Neuroscience in the 21st Century

Abstract

The somatosensory system enables organisms to feel, to ache, to chill, and, perhaps most importantly, to know which parts of the body are involved in these sensations. This comprises proprioceptive and cutaneous sensitivity. Somatosensory receptors are distributed throughout the body rather than being concentrated at specialized locations and are able to sense different kinds of stimuli such as pressure against the skin, limb position, distention of the bladder, and body temperature. If a stimulus becomes so strong that it may be harmful, the somatosensory system is also responsible for feeling pain (nociception).

The skin is the largest sensory organ, and a variety of stimuli from the external environment are constantly contacting its surface. These stimuli are sensed by specialized endings of sensory neurons called receptors, which then transmit signals to the spinal cord and brain for interpretation and response. A single stimulus usually activates many receptors, and each receptor is capable of encoding stimulus features such as intensity, duration, and direction. It is the central nervous system (CNS) that interprets the activity of the different receptors involved in the sensation and uses these interpretations to generate coherent perceptions.

In this chapter, the skin as a sensory organ will be discussed and its role in the sense of touch, nonpainful changes of temperature, itch, and pleasant touch.

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Abbreviations

AM:

A-mechanonociceptor

AMPA:

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

ASIC:

Acid – sensing ion channel

ADP:

Adenosine diphosphate

ATP:

Adenosine triphosphate

BC:

Basal cell

BL:

Basal lamina

cAMP:

Cyclic adenosine monophosphate

CF:

Cuneate fascicle

cGMP:

Cyclic guanosine monophosphate

CGRP:

Calcitonin gene-related peptide

CLTM:

Tactile fibers

CN:

Clarke’s nucleus

CNS:

Central nervous system

CT:

Unmyelinated fibers

D:

Desmosome

Deg/ENaC:

Degenerin epithelial sodium channel

DM:

Dermal papillae

DRG:

Dorsal root ganglion

FA:

Fast adapting

FNE:

Free nerve endings

G-protein:

Guanine nucleotide-binding protein

GF:

Gracile fascicle

HFR:

Hair follicle root

IN:

Intermediolateral nucleus

K:

Keratinocytes

MC:

Meissner’s corpuscles

MD:

Merkel’s disks

MEC:

Ion channel

mGluR5:

Metabotropic glutamate receptor 5

ML:

Medial lemniscus

MN:

Motor nucleus

MZ:

Marginal zone

NGF:

Nerve growth factor

NMDA:

N-methyl D-aspartate

NP:

Nucleus proprius

PC:

Paccinian corpuscles

P2X:

ATP activated purinergic receptor

P2Y:

G-protein coupled receptor

PGP:

Protein gene product

PV:

Paraventricular nucleus

RA:

Rapidly adapting

RE:

Ruffini’s endings

SAM:

Slowly adapting mechanoreceptor

SA:

Slowly adapting

SC:

Caudal somatosensory area

SB:

Stratum basale

SG:

Substantia gelatinosa

SP:

Substance P (neuropeptide)

SR:

Rostral somatosensory area

SSC:

Somatic sensory cortex

SI:

Primary somatosensory cortex

SII:

Secondary somatosensory cortex

T:

Thalamus

TREK1:

Mechanosensitive potassium channel

TRP:

Transient receptor potential

UTP:

Uridine triphosphate

VgluT:

Vesicular glutamate transporter

VIP:

Vasoactive intestinal peptide

VP:

Ventro posterior nucleus

VPM:

Ventroposterior medial nucleus

VPLN:

Ventral posterior lateral nucleus

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Correspondence to Nieves Martín-Alguacil DVM, Ph.D. .

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Martín-Alguacil, N., de Gaspar, I., Schober, J.M., Pfaff, D.W. (2013). Somatosensation: End Organs for Tactile Sensation. In: Pfaff, D.W. (eds) Neuroscience in the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1997-6_27

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