Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Boron, Biologically Active Compounds

  • Leonid Breydo
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_483



Boron-containing compounds are primarily utilized by bacteria as quorum autoinducers and by plants as components of the cell wall. Many synthetic organoboron compounds are used as enzyme inhibitors.


Boron is a ubiquitous element in rocks, soil, and water; its average concentration ranging from 1 mg/kg in water to 100 mg/kg in rocks. Boron is electron-poor and prefers to form tetracoordinate complexes with “hard” nucleophiles. In physiological environment, it is present in +3 oxidation state, usually in the form of borate anion or borate esters. Borate anions form stable complexes with organic acids, polysaccharides, and other biopolymers. Usually borate complexes two hydroxyl groups (either a diol or a hydroxycarboxylic acid) to form a borate diester. Since boron can bind four ligands, in many cases, borate esters cross-link two organic molecules together.

Boron in...

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  1. Armstrong TA, Spears JW, Crenshaw TD, Nielsen FH (2000) Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites. J Nutr 130:2575–2581PubMedGoogle Scholar
  2. Brown PH, Bellaloui N, Wimmer MA, Bassil ES, Ruiz JH, Pfeffer H, Dannel F, Romheld V (2002) Boron in plant biology. Plant Biol 4:205–223CrossRefGoogle Scholar
  3. Chen TS, Chang CJ, Floss HG (1980) Biosynthesis of the boron-containing antibiotic aplasmomycin. Nuclear magnetic resonance analysis of aplasmomycin and desboroaplasmomycin. J Antibiot (Tokyo) 33:1316–1322CrossRefGoogle Scholar
  4. Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM (2002) Structural identification of a bacterial quorum-sensing signal containing boron. Nature 415:545–549PubMedCrossRefGoogle Scholar
  5. Dembitsky VM, Al Quntar AA, Srebnik M (2011) Natural and synthetic small boron-containing molecules as potential inhibitors of bacterial and fungal quorum sensing. Chem Rev 111:209–237PubMedCrossRefGoogle Scholar
  6. Federle MJ (2009) Autoinducer-2-based chemical communication in bacteria: complexities of interspecies signaling. Contrib Microbiol 16:18–32PubMedCrossRefGoogle Scholar
  7. Fort DJ, Rogers RL, McLaughlin DW, Sellers CM, Schlekat CL (2002) Impact of boron deficiency on Xenopus laevis: a summary of biological effects and potential biochemical roles. Biol Trace Elem Res 90:117–142PubMedCrossRefGoogle Scholar
  8. Hodgkinson JT, Welch M, Spring DR (2007) Learning the language of bacteria. ACS Chem Biol 2:715–717PubMedCrossRefGoogle Scholar
  9. Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55:165–199PubMedCrossRefGoogle Scholar
  10. O'Neill MA, Ishii T, Albersheim P, Darvill AG (2004) Rhamnogalacturonan II: structure and function of a borate cross-linked cell wall pectic polysaccharide. Annu Rev Plant Biol 55:109–139PubMedCrossRefGoogle Scholar
  11. Pellerin P, O'Neill MA (1998) The interaction of the pectic polysaccharide Rhamnogalacturonan II with heavy metals and lanthanides in wines and fruit juices. Analusis 26:32–36CrossRefGoogle Scholar
  12. Rock FL, Mao W, Yaremchuk A, Tukalo M, Crepin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ et al (2007) An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 316:1759–1761PubMedCrossRefGoogle Scholar
  13. Takano J, Noguchi K, Yasumori M, Kobayashi M, Gajdos Z, Miwa K, Hayashi H, Yoneyama T, Fujiwara T (2002) Arabidopsis boron transporter for xylem loading. Nature 420:337–340PubMedCrossRefGoogle Scholar
  14. Vithana EN, Morgan P, Sundaresan P, Ebenezer ND, Tan DT, Mohamed MD, Anand S, Khine KO, Venkataraman D, Yong VH et al (2006) Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2). Nat Genet 38:755–757PubMedCrossRefGoogle Scholar
  15. Xavier KB, Bassler BL (2005) Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol 187:238–248PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Molecular Medicine, Morsani College of MedicineUniversity of South FloridaTampaUSA