Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Blood Clotting Proteins

  • Sheryl R. Bowley
  • Mingdong Huang
  • Barbara C. Furie
  • Bruce Furie
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_46



Coagulation: blood clotting

Gla: γ-carboxyglutamic acid is formed by posttranslational addition of a carboxyl group to the γ-carbon of glutamic acid

Thrombosis: formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system

Procofactors: proteins whose binding to another coagulation protein requires proteolytic cleavage for full activity of the complex

Tenase complex: a complex formed by the assembly of factors IXa and VIIIa on a cell membrane that converts factor X to active factor Xa

Prothrombinase complex: a complex formed by the association of factors Va and Xa on a cell membrane that converts prothrombin to thrombin

EGF-like domain: a protein domain conserved through evolution that includes an N-terminal two-stranded beta-sheet followed by a loop and a short C-terminal two-stranded beta-sheet


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sheryl R. Bowley
    • 1
  • Mingdong Huang
    • 1
  • Barbara C. Furie
    • 1
  • Bruce Furie
    • 1
  1. 1.Division of Hemostasis and ThrombosisBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA