Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Blood Clotting Proteins

  • Sheryl R. Bowley
  • Mingdong Huang
  • Barbara C. Furie
  • Bruce Furie
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_46

Synonyms

Definitions

Coagulation: blood clotting

Gla: γ-carboxyglutamic acid is formed by posttranslational addition of a carboxyl group to the γ-carbon of glutamic acid

Thrombosis: formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system

Procofactors: proteins whose binding to another coagulation protein requires proteolytic cleavage for full activity of the complex

Tenase complex: a complex formed by the assembly of factors IXa and VIIIa on a cell membrane that converts factor X to active factor Xa

Prothrombinase complex: a complex formed by the association of factors Va and Xa on a cell membrane that converts prothrombin to thrombin

EGF-like domain: a protein domain conserved through evolution that includes an N-terminal two-stranded beta-sheet followed by a loop and a short C-terminal two-stranded beta-sheet

B...

This is a preview of subscription content, log in to check access

References

  1. Adams TE, Hockin MF, Mann KG, Everse SJ (2004) The crystal structure of activated protein C-inactivated bovine factor Va: implications for cofactor function. Proc Natl Acad Sci USA 101:8918–8923PubMedCrossRefGoogle Scholar
  2. Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D (1996) The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380:41–46PubMedCrossRefGoogle Scholar
  3. Furie B, Furie BC (2008) Mechanisms of thrombus formation. N Engl J Med 359:938–949PubMedCrossRefGoogle Scholar
  4. Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC (2003) Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol 10:751–756PubMedCrossRefGoogle Scholar
  5. Huang M, Furie BC, Furie B (2004) Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J Biol Chem 279:14338–14346PubMedCrossRefGoogle Scholar
  6. Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle RF (2009) Crystal structure of human fibrinogen. Biochemistry 48:3877–3886PubMedCrossRefGoogle Scholar
  7. Komaromi I, Bagoly Z, Muszbek L (2011) Factor XIII: novel structural and functional aspects. J Thromb Haemost 9(1):9–20PubMedCrossRefGoogle Scholar
  8. Ngo JC, Huang M, Roth DA, Furie BC, Furie B (2008) Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure 16:597–606PubMedCrossRefGoogle Scholar
  9. Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL (1999) Structure of the C2 domain of human factor VIII at 1.5 Å resolution. Nature 402:439–442PubMedCrossRefGoogle Scholar
  10. Shen BW, Spiegel PC, Chang CH, Huh JW, Lee JS, Kim J, Kim YH, Stoddard BL (2008) The tertiary structure and domain organization of coagulation factor VIII. Blood 111:1240–1247PubMedCrossRefGoogle Scholar
  11. Soriano-Garcia M, Padmanabhan K, de Vos AM, Tulinsky A (1992) The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1. Biochemistry 31:2554–2566PubMedCrossRefGoogle Scholar
  12. Weisel JW (2005) Fibrinogen and fibrin. Adv Protein Chem 70:247–299PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sheryl R. Bowley
    • 1
  • Mingdong Huang
    • 1
  • Barbara C. Furie
    • 1
  • Bruce Furie
    • 1
  1. 1.Division of Hemostasis and ThrombosisBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA