Bacterial Mercury Resistance Proteins
Bacteria carry out chemical transformations of mercury compounds. Often these transformations result from bacterial resistance systems to inorganic mercury (Hg2+) and to organomercurials (such as methylmercury and phenylmercury). There are four types of mercury-specific proteins: detoxifying enzymes producing less toxic products, membrane transport proteins that bring Hg2+ into the cells to be detoxified, mercury-binding proteins at the outer cell surface, and DNA-binding transcriptional regulatory proteins governing mRNA synthesis (Barkay et al. 2003; Silver and Phung 2005; Silver and Hobman 2007).
Mercury Resistance (the mer Operon)
- Ledwidge R, Patel B, Dong A, Fiedler D, Falkowski M, Zelikova J, Summers AO, Pai EF, Miller SM (2005) NmerA, the metal binding domain of mercuric ion reductase, removes Hg2+ from proteins, delivers it to the catalytic core, and protects cells under glutathione-depleted conditions. Biochemistry 44:11402–11416PubMedCrossRefGoogle Scholar