Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Bacterial Calcium Binding Proteins

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_266



Bacterial proteins that bind calcium and are implicated in the regulation of various cellular events. These proteins appear to be involved in a wide variety of functions including chemotaxis, heat shock, pathogenesis, transport (influx and efflux), cell differentiation, and cell signaling.


The calcium ion (Ca2+) is perhaps the most important intracellular messenger in eukaryotes and regulates many cellular processes including cell differentiation, movement, cell cycle, transport mechanisms, and gene expression (Celio et al. 1996). Many effects of Ca2+ are mediated by  calcium-binding proteins (CaBPs). Some of these proteins act as Ca2+ reservoirs or buffers. More specialized CaBPs such as calmodulin, act as signal transducers activating phosphorylation cascades leading to regulation in gene expression, and control of Ca2+ channel activity.

In prokaryotes, a similar role for Ca2+has been proposed...

This is a preview of subscription content, log in to check access.


  1. Barnwal RP et al (2009) Solution structure and calcium-binding properties of M-crystallin, a primordial betagamma-crystallin from archaea. J Mol Biol 386:675–689PubMedCrossRefGoogle Scholar
  2. Bilecen K, Yildiz FH (2009) Identification of a calcium-controlled negative regulatory system affecting Vibrio cholerae biofilm formation. Environ Microbiol 11:2015–2029PubMedCrossRefGoogle Scholar
  3. Celio MR, Tomas P, Shawler B (1996) Guidebook to the calcium-binding proteins. Sambrook & Tooze, Oxford University Press, OxfordGoogle Scholar
  4. Dominguez DC (2004) Calcium signalling in bacteria. Mol Microbiol 54:291–297PubMedCrossRefGoogle Scholar
  5. Kretsinger RH (1976) Calcium-binding proteins. Annu Rev Biochem 45:239–266PubMedCrossRefGoogle Scholar
  6. Michiels J et al (2002) The functions of Ca(2+) in bacteria: a role for EF-hand proteins? Trends Microbiol 10:87–93PubMedCrossRefGoogle Scholar
  7. Naseem R et al (2009) ATP regulates calcium efflux and growth in E. coli. J Mol Biol 391:42–56PubMedCrossRefGoogle Scholar
  8. Norris et al (1996) “Bacterial calcium-binding proteins”. In: Celio MR, Pauls TL, Schwaller B (eds) Sambrook & Tooze. Oxford University Press, pp 209–212Google Scholar
  9. Saaf A et al (2001) The internal repeats in the Na+/Ca2+ exchanger-related Escherichia coli protein YrbG have opposite membrane topologies. J biol chem 276:18905–18907PubMedCrossRefGoogle Scholar
  10. Sharma Y, Balasubramanian D (1996) “Crystallins”. In: Celio MR, Pauls TL, Schwaller B (eds) Sambrook & Tooze. Oxford University Press, pp 225–228Google Scholar
  11. Shemarova IV, Nesterov VP (2005) Evolution of mechanisms of calcium signaling: the role of calcium ions in signal transduction in prokaryotes. Zh Evol Biokhim Fiziol 41:12–17PubMedGoogle Scholar
  12. van Veen HW et al (1994) Translocation of metal phosphate via the phosphate inorganic transport system of Escherichia coli. Biochemistry 33:1766–1770PubMedCrossRefGoogle Scholar
  13. Wang SL et al (2008) CabC, an EF-hand calcium-binding protein, is involved in Ca2+-mediated regulation of spore germination and aerial hypha formation in Streptomyces coelicolor. J Bacteriol 190:4061–4068PubMedCrossRefGoogle Scholar
  14. Zhou Y et al (2006) Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins. Proteins 65:643–655PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.College of Health SciencesThe University of Texas at El PasoEl PasoUSA
  2. 2.Department of Microbiology and Molecular Genetics, College of Arts and SciencesOklahoma State UniversityStillwaterUSA