Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Bismuth, Interaction with Gastrin

  • Graham S. Baldwin
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_200004


The peptide hormone gastrin was originally identified as a stimulant of acid secretion, but is now known to also act as a growth factor in the gastrointestinal tract (Dockray et al. 2001). Gastrin is synthesized as a precursor of 101 amino acids (preprogastrin) which, on removal of the signal peptide of 21 amino acids, yields progastrin (80 amino acids). Proteolytic processing in antral G cells in the stomach generates a number of intermediate peptides, including glycine-extended gastrin17 (Ggly), which has the sequence ZGPWLEEEEEAYGWMDFG. Transamidation of the C-terminal glycine yields the C-terminal amidated phenylalanine characteristic of amidated gastrin (Gamide). Both Ggly and Gamide are independently active, via different receptors, in the gastrointestinal tract.

Basic Characteristics

Iron: Interaction with Gastrin

Fluorescence experiments have revealed that both Ggly and Gamide bind two ferric ions with high affinity (Kd= 0.6 μM, pH 4.0) in aqueous solution (Baldwin...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Surgery, Austin HealthThe University of MelbourneHeidelbergAustralia